Estimated pulse wave velocity predicts severe COVID

Date:
October 13, 2021
Source:
Newcastle University
Summary:
Researchers found that estimated Pulse Wave Velocity (ePWV), a
readily available marker of arterial stiffness, has been shown
to be an effective addition in identifying patients at risk of
mortality in hospital due to COVID-19.



FULL STORY ========================================================================== Assessing the stiffness of the arteries could help identify patients
most at risk of dying from Covid-19, new research has revealed.


========================================================================== Estimated pulse wave velocity (ePWV), a readily available marker of aortic stiffening, has been shown to be an effective addition in identifying
patients at risk of death in hospital due to the virus.

Accurate risk stratification at hospital admission of these patients
is of utmost clinical importance as it is needed to guide therapeutic strategies.

The research is published in Scientific Reports today by Professor
Konstantinos Stellos and Visiting Clinical Professor Kimon Stamatelopoulos
at Newcastle University, UK and the Newcastle Hospitals NHS Foundation
Trust. It demonstrates that ePWV provides an additional clinical tool to
refine risk stratification of hospitalized patients beyond established
risk factors and scores.

The study was carried out in two cohorts of hospitalized Covid-19
patients; 471 in the Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK and 266 in the University Hospital of Pisa, Tuscany, Italy
and in a control cohort of 934 non-Covid-19 individuals in the Department
of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.

It was found that the addition of ePWV to clinical predictive markers or
a validated mortality score improved the prognostic value for in-hospital mortality and therefore could facilitate therapeutic decisions in acute
Covid- 19 disease.

Professor Stellos, Professor of Cardiovascular Medicine at Newcastle
University and Heidelberg University, said: "Our findings suggest that increased aortic stiffening may serve as a predictor of mortality in
Covid-19 infection reflecting a cumulative surrogate of ageing and
high-risk cardiovascular profile." The team found that the optimal
prognostic ePWV value was 13.0 m/sec for predicting in-hospital mortality.

When the total cohort of patients with COVID-19 (n=737) was compared
with the total control cohort (n=934), ePWV progressively increased
across the controls, COVID-19 survivors and COVID-19 patients who didn't survive after controlling for age, sex, hypertension and other relevant factors. ePWV was significantly higher in COVID-19 patients as compared
to their non-COVID-19 counterparts.

The readily available measure of arterial stiffness when used in addition
to tools already recommended in clinical practice may facilitate
therapeutic decisions in acute Covid-19 disease. The team will be
continuing further research in this area to develop the technique and
seek its validation into health service practice.

What is Estimated Pulse wave velocity? Pulse-wave velocity (ePWV)
is a measurement of aortic stiffness that is an independent predictor
of cardiovascular risk and can be calculated by using age and blood
pressure in a recently validated formula. It closely predicts the actual
PWV assessed noninvasively by measuring the carotid and femoral pulse pressures, with sensors on the ankles and neck, and the time delay
between the two or by other methods relying on pulse-wave analysis.

========================================================================== Story Source: Materials provided by Newcastle_University. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Kimon Stamatelopoulos, Georgios Georgiopoulos, Kenneth F. Baker,
Giusy
Tiseo, Dimitrios Delialis, Charalampos Lazaridis, Greta Barbieri,
Stefano Masi, Nikolaos I. Vlachogiannis, Kateryna Sopova,
Alessandro Mengozzi, Lorenzo Ghiadoni, Ina Schim van der Loeff,
Aidan T. Hanrath, Bajram Ajdini, Charalambos Vlachopoulos, Meletios
A. Dimopoulos, Christopher J.

A. Duncan, Marco Falcone, Konstantinos Stellos, Giusy Tiseo,
Greta Barbieri, Stefano Masi, Alessandro Mengozzi, Lorenzo
Ghiadoni, Marco Falcone, Fabio Monzani, Francesco Menichetti,
Agostino Virdis, Francesco Forfori, Baldassarri Rubia, Bertini
Pietro, Brizzi Giulia, Corradi Francesco, Della Rocca Alessandra,
Guarracino Fabio, Malacarne Paolo, Monfroni Marco, Piagnani Chiara,
Park Naria, Celi Alessandro, Laura Carrozzi, Cinotti Francesco,
Massimo Santini, Cipriano Alessandro, Biancalana Martina, Borselli
Matteo, Nencini Elia, Spinelli Stefano, Ruberti Francesca, Forotti
Giovanna, Sciuto Maria, Salvatore De Marco, Antognoli Rachele,
Calsolario Valeria, Paterni Simone, Colangelo Luciano, Sonato
Chiara, Galfo Valentina, Monica Uliana, Kenneth F. Baker, Ina Schim
van der Loeff, Aidan T. Hanrath, Christopher J. A. Duncan, Su Ann
Tee, Richard Capstick, Gabriella Marchitelli, Ang Li, Andrew Barr,
Alsafi Eid, Sajeel Ahmed, Dalvir Bajwa, Omer Mohammed. Estimated
pulse wave velocity improves risk stratification for all-cause
mortality in patients with COVID-19. Scientific Reports, 2021; 11
(1) DOI: 10.1038/s41598-021- 99050-0 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/10/211013114101.htm

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