Sweet! How glycogen is linked to heat generation in fat cells

Date:
October 27, 2021
Source:
University of California - San Diego
Summary:
Researchers describe how energy expenditure and heat production are
regulated in obesity through a previously unknown cellular pathway.



FULL STORY ========================================================================== Humans carry around with them, often abundantly so, at least two
kinds of fat tissue: white and brown. White fat cells are essentially
inert containers for energy stored in the form of a single large,
oily droplet. Brown fat cells are more complex, containing multiple,
smaller droplets intermixed with dark- colored mitochondria -- cellular organelles that give them their color and are the "engines" that convert
the lipid droplets into heat and energy.


==========================================================================
Some people also have "beige" fat cells, brown-like cells residing within
white fat that can be activated to burn energy.

In recent years, there has been much effort to find ways to increase brown
or beige fat cell activity, to induce fat cells, known as adipocytes,
to burn energy and generate heat in a process called thermogenesis as
a means to treat obesity, type 2 diabetes and other conditions.

But the therapeutic potential of brown fat -- and perhaps beige fat cells
- - has been stymied by the complexity of the processes involved. It
wasn't until 2009 that the existence of active brown fat cells in healthy adults was confirmed; previously it was believed they were common only
in newborns.

In a new study, published online October 27, 2021 in Nature, an
international team of researchers led by senior author Alan Saltiel,
PhD, director of the Institute for Diabetes and Metabolic Health at
University of California San Diego School of Medicine, describe how
energy expenditure and heat production are regulated in obesity through
a previously unknown cellular pathway.

The human body breaks down consumed carbohydrates into a type of sugar
called glucose, which is the main source of fuel for cells. Unneeded
glucose is packaged and stored as glycogen in liver and skeletal muscle
cells, where it can be extracted and quickly used for sudden energy
needs or to maintain blood sugar levels.

Unlike in muscle and liver, the role of glycogen in fat has been a
mystery. The researchers discovered that glycogen does much more than
simply store energy in fat cells. It provides a signal that produces a
major shift in how energy is handled.

In this "surprise discovery," Saltiel and colleagues report that the
browning of fat cells depends on their ability to both make and then
degrade glycogen.

The turnover of glycogen sends a signal that it is safe for the cell to "uncouple" the production of ATP, the molecule that provides the energy
that fuels most cellular processes.

"Uncoupling is a way to generate heat, and in the process help balance
energy.

This pathway thus ensures that only the fat cells with enough energy
stores to fuel the generation of heat are allowed to do so," said Saltiel.

The dramatic increase in worldwide obesity -- 650 million people or
13 percent, a tripling since 1975 -- has underscored the importance of understanding how the human body balances energy intake and expenditure.

Glycogen regulates and promotes fat metabolism: the higher the levels,
the more robust the metabolic processes, essentially burning fat quicker
with resulting weight loss in obese mice. In humans, the genes involved in these complex processes were found to be lower in patients who were obese
or prone to weight gain, suggesting that the glycogen pathway is needed in
fat cells to burn off excess weight. The new findings, wrote the authors, suggest that modulating glycogen metabolism in fat cells might provide new approaches for weight loss and overall improvement in metabolic health.

Co-authors include: Omer Keinan, Joseph M. Valentine, Shannon M. Reilly, Mohammad Abu-Odeh, Julia H. Deluca, Benyamin Dadpey, Leslie Cho and
Austin Pan, all at UC San Diego; Haopeng Xiao and Edward T. Chouchani, Dana-Farber Cancer Institute and Harvard University; Sushil K. Mahata,
VA San Diego Healthcare System and UC San Diego; Ruth T. Yu, Yang Dai,
Michael Downes and Ronald M.

Evans, Salk Institute; Christopher Liddle, University of Sydney,
Australia; Aldons J. Lusis, UCLA; Markku Laakso, University of Eastern
Finland; and Mikael Ryde'n, Karolinska Institutet.

========================================================================== Story Source: Materials provided by
University_of_California_-_San_Diego. Original written by Scott
LaFee. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Omer Keinan, Joseph M. Valentine, Haopeng Xiao, Sushil K. Mahata,
Shannon
M. Reilly, Mohammad Abu-Odeh, Julia H. Deluca, Benyamin Dadpey,
Leslie Cho, Austin Pan, Ruth T. Yu, Yang Dai, Christopher Liddle,
Michael Downes, Ronald M. Evans, Aldons J. Lusis, Markku Laakso,
Edward T.

Chouchani, Mikael Ryde'n, Alan R. Saltiel. Glycogen metabolism
links glucose homeostasis to thermogenesis in adipocytes. Nature,
2021; DOI: 10.1038/s41586-021-04019-8 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/10/211027122147.htm

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