Bone mineral density decreases less than expected after menopause

Date:
October 27, 2021
Source:
University of Eastern Finland
Summary:
Bone mineral density at the femoral neck bone in postmenopausal
women decreased by an average of 10% during a 25-year follow-up,
according to a new study. Being the world's hitherto longest
follow-up of changes in bone mineral density in postmenopausal
women, the study shows that bone loss after menopause is
significantly lower than has previously been assumed on the basis
of earlier studies.



FULL STORY ==========================================================================
Bone mineral density at the femoral neck bone in postmenopausal women
decreased by an average of 10% during a 25-year follow-up, according
to a new study from the University of Eastern Finland. Being the
world's hitherto longest follow-up of changes in bone mineral density
in postmenopausal women, the study shows that bone loss after menopause
is significantly lower than has previously been assumed on the basis of
earlier studies. Women with the highest bone mineral density at baseline
had the highest bone loss percentage when compared to baseline.


==========================================================================
The Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study began in
1989 with a health survey that was sent to all women aged 47-56 living in
the Kuopio region, eastern Finland. A total of 14,200 women received the survey, and it has been repeated at five-year intervals. In addition,
a randomised sample of 3,000 women have participated in bone mineral
density measurements every five years. The study is still ongoing,
with 30-year measurements currently under way.

Published in Journal of Bone and Mineral Research, the present findings
are from the 25-year follow-up. The study included all OSTPRE study participants who had participated in all of the bone mineral density measurements during the 25-year follow-up.

"The average decrease in bone mineral density was lower than has
been assumed on the basis of earlier, shorter follow-ups where the
bone loss rate at the femoral neck has been estimated to be even more
than 20%. There were also surprisingly few risk factors affecting bone
mineral density. The most significant factor protecting against bone
loss was hormone replacement therapy. Weight gain during the follow-up
also protected against bone loss," Associate Professor Joonas Sirola
from the University of Eastern Finland says.

"This new, long-term follow-up of bone mineral density sheds significant
new light on osteoporosis and bone research, and also changes our
understanding of bone loss in older women," Professor Heikki Kro"ger
from the University of Eastern Finland says.

========================================================================== Story Source: Materials provided by University_of_Eastern_Finland. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Anna Moilanen, Juho Kopra, Heikki Kro"ger, Reijo Sund, Toni
Rikkonen,
Joonas Sirola. Characteristics of Long‐Term Femoral
Neck Bone Loss in Postmenopausal Women: A 25‐Year
Follow‐Up. Journal of Bone and Mineral Research, 2021; DOI:
10.1002/jbmr.4444 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/10/211027122047.htm

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