New symptoms identified that could help doctors diagnose pancreatic
cancer

Date:
November 8, 2021
Source:
National Cancer Research Institute
Summary:
Researchers have identified a series of symptoms associated with
pancreatic cancer, including two previously unrecognised symptoms -
- feeling thirsty and having dark urine.



FULL STORY ========================================================================== Researchers have identified a series of symptoms associated with
pancreatic cancer, including two previously unrecognised symptoms --
feeling thirsty and having dark urine -- in a study presented today
(Monday) at the NCRI Festival.


==========================================================================
The study has confirmed a further 21 signs of pancreatic cancer and shown
that patients often have some symptoms of the disease up to a year before
their cancers are diagnosed, and other alarming symptoms three months
before diagnosis.

The researchers hope their findings could improve survival by helping
GPs diagnose the disease earlier, especially when patients present with
several seemingly non-specific symptoms.

Pancreatic cancer has the lowest survival among all common cancers, with
five- year survival around 7% in the UK. Unfortunately, most people with pancreatic cancer are diagnosed at a late stage.

Researchers want to better understand the early signs of pancreatic
cancer because if patients and GPs are more aware of symptoms, they
could be diagnosed earlier when their chance of survival is better.

The research is presented by Dr Weiqi Liao, a data scientist at the
University of Oxford, UK. He and his colleagues looked at data from
24,236 patients who were diagnosed with pancreatic cancer in England
between 2000 and 2017 using a large electronic database (QResearch). The researchers looked at patients' symptoms at different time points before
they were diagnosed with cancer and compared them to other patients'
symptoms who were not diagnosed with pancreatic cancer.



========================================================================== Yellowing of the skin (jaundice) and bleeding in the stomach or intestine
were the two serious symptoms most associated with being diagnosed
with pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, and in pancreatic neuroendocrine neoplasms (PNEN),
a rarer form of pancreatic cancer.

In addition, researchers identified thirst and dark urine as previously
unknown symptoms for PDAC.

Dr Liao said: "When pancreatic cancer is diagnosed earlier, patients
have a higher chance of survival. It is possible to diagnose patients
when they visit their GP, but both patients and GPs need to be aware
of the symptoms associated with pancreatic cancer." The research,
which is the largest study of its kind, found 23 symptoms linked with
the diagnosis of PDAC (yellowing of the skin, bleeding in the stomach
or intestine, problems swallowing, diarrhea, change in bowel habits,
vomiting, indigestion, abdominal mass, abdominal pain, weight loss, constipation, fat in stool, abdominal swelling, nausea, flatulence,
heartburn, fever, tiredness, appetite loss, itching, back pain, thirst,
and dark urine). Nine symptoms were linked with PNEN (yellowing of
the skin, blood in stool, diarrhea, change in bowel habits, vomiting, indigestion, abdominal mass, abdominal pain, and weight loss).

While most symptoms were not specific to pancreatic cancer and could be
due to other benign conditions, the researchers found patients diagnosed
with pancreatic cancer had a higher chance of experiencing some of these
non- specific symptoms one year before diagnosis.

Dr Liao said: "These new findings enable us to conduct further work
on understanding symptoms that could suggest pancreatic cancer. This
will help GPs to make decisions about who to refer for urgent tests,
especially when patients have several seemingly non-specific symptoms." Although this study is one of the largest of its kind, the oldest data did
not include what stage the patients' cancer was when they were diagnosed, meaning the researchers were not able to explore which symptoms were
associated with early-stage disease and which with late-stage disease. In addition, as PNEN is a rarer cancer, there is only a small amount of data available in the study period, meaning it is harder for researchers to
detect other potential symptoms.



==========================================================================
Dr Liao is also working with other researchers to compare these findings
with symptom data from other groups of patients.

Dr Pippa Corrie is chair of the pancreatic workstream of the NCRI Upper Gastrointestinal Group and Consultant Medical Oncologist at Addenbrooke's Hospital, Cambridge, UK, and was not involved with the research. She
said: "Being aware of the early symptoms of pancreatic cancer is crucial
if we are to diagnose patients earlier and improve pancreatic cancer
survival. This research could help GPs and their patients know more
about the signs of pancreatic cancer. It's vital that people speak to
their GP if they notice these symptoms.

"Future research could help us develop tools for GPs to help them make referrals, especially when patients present with several non-specific symptoms." Professor Julia Hippisley-Cox, who led the study and is
based at the University of Oxford, said: "We thank the many hundreds of
GPs using EMIS -- an electronic patient record system widely used in the
UK -- who contribute anonymised data to the QResearch database, without
whom this novel research in such a rare but important condition, would not
have been possible." These results could now be used to update QCancer, a
risk prediction model that has been created from the QResearch database to
help GPs identify high-risk patients for further tests to diagnose cancer.

Dr Chris Macdonald, Head of Research at Pancreatic Cancer UK, which funded
the research, said: "This new analysis, and the QCancer tool itself, is
filling a gaping hole in the way that pancreatic cancer is diagnosed. It
could give GPs a much-needed way of identifying patients who are at risk
of the disease so that they can be referred for diagnostic tests earlier
and, ultimately, get treatment before it's too late.

"This research is an important component of our Early Diagnosis Research Alliance, which has brought together leading researchers across the UK to
make earlier diagnosis a reality for the deadliest common cancer. Their
efforts mean a new diagnostic test for pancreatic cancer is now on the
horizon. However, we also need vital risk assessment tools like QCancer optimised and in the hands of GPs, if we're to ensure that anyone who
might have this devastating disease has the very best chance of survival." ========================================================================== Story Source: Materials provided by
National_Cancer_Research_Institute. Original written by Rachel
Laurence. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Weiqi Liao, Ashley K Clift, Martina Patone, Carol Coupland, Arturo
Gonza'lez-Izquierdo, Stephen P Pereira, Julia
Hippisley-Cox. Identifying symptoms associated with diagnosis
of pancreatic exocrine and neuroendocrine neoplasms: a nested
case-control study of the UK primary care population. British
Journal of General Practice, 2021; 71 (712): e836 DOI:
10.3399/BJGP.2021.0153 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/11/211108081631.htm

--- up 9 weeks, 4 days, 9 hours, 25 minutes
* Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3)