• Scientists key in on brain's mechanism f

    From ScienceDaily@1:317/3 to All on Fri Nov 19 21:30:34 2021
    Scientists key in on brain's mechanism for singing, learning
    Mechanism for brain's ability to learn fine motor skills

    Date:
    November 19, 2021
    Source:
    Oregon Health & Science University
    Summary:
    New research reveals that specialized cells within neural
    circuitry that triggers complex learning in songbirds bears a
    striking resemblance to a type of neural cell associated with the
    development of fine motor skills in the cortex of the human brain.



    FULL STORY ==========================================================================
    New research reveals that specialized cells within neural circuitry that triggers complex learning in songbirds bears a striking resemblance to a
    type of neural cell associated with the development of fine motor skills
    in the cortex of the human brain.


    ==========================================================================
    The study by scientists at Oregon Health & Science University published
    today in the journal Nature Communications.

    "These are the properties you need if you want to have a male song that's precise and distinct so the female can choose which bird she wants to
    mate with," said co-senior author Henrique von Gersdorff, Ph.D., senior scientist the OHSU Vollum Institute. "You need a highly specialized brain
    to produce this." Benjamin Zemel, Ph.D., a postdoctoral fellow at OHSU,
    is lead author and conducted most of the challenging electrophysiology
    work involved in using thin brain slices and single cell recording.

    The study reveals that a particular group of neurons express a set of
    genes that modulate sodium ion channel proteins. These ion channels
    generate electrical signals used for communication between cells in the
    nervous system.

    In this case, the assemblage enables neurons to fire repetitive spikes -
    known as action potentials - at extremely high speeds and frequencies
    as the bird sings.

    The study describes "ultrafast spikes" that only last 0.2 milliseconds
    - compared with most action potential spikes that last a millisecond
    or more. A millisecond is itself mind-bendingly fast, a thousandth of
    a second.



    ========================================================================== Further, the findings suggest new avenues for understanding the mechanism
    in various aspects of human behavior and development that involves fine
    motor control.

    Researchers say the assemblage of neurons and ion channels involved in
    the male zebra finch's singing closely resembles a similar assemblage
    of neurons known as Betz cells in the primary motor cortex of the
    human brain.

    Among the largest known brain cells in humans, Betz cells have long
    and thick axons that can propagate spikes at very high velocities and frequencies. As such, they are thought to be important for fine motor
    skills involving hands, feet, fingers and wrists.

    "Think of a piano player," said co-senior author Claudio Mello, M.D.,
    Ph.D., professor of behavioral neuroscience in the OHSU School of
    Medicine. "They're thinking so fast, they have to rely on memories
    and actions that are learned and stored. Playing the guitar is the
    same thing." The study published today is a result of an informal
    conversation that initially occurred over lunch in the Mackenzie Hall
    Cafe' on OHSU's Marquam Hill campus.



    ========================================================================== Mello, a behavioral neuroscientist who has relied on the zebra finch
    as an animal model, has known Von Gersdorff socially for 20 years. Over
    lunch one day in the cafeteria, Mello popped open his laptop and showed
    a brain image of a young male zebra finch at an age just before he could
    sing, followed by a second image revealing a telltale subunit of proteins
    that had materialized after the bird was old enough to begin singing.

    "Something remarkable was happening in a period of just a few days,"
    said von Gersdorff, an expert in electrophysiology and the biophysics of neurons. "I said, this is exactly the protein we've been studying in the
    rodent auditory system. It promotes high frequency spiking." Mello said
    the new study deepens scientific understanding of the mechanism involved
    in learning fine motor skills.

    "This is a very important model, and we think this new study has broad potential," he said.

    The fact that these same motor circuit properties are shared by species
    that diverged more than 300 million years ago speaks to the strength of
    the discovery, von Gersdorff and Mello said. Researchers say the neuronal properties they discovered in the male zebra finch may become optimized
    for speed and precision through convergent evolution.

    It also suggests mechanisms that may be involved when the connection
    goes awry.

    Von Gersdorff said it's possible that some gene mutations affecting
    these Betz cells may cause relatively mild effects such as stuttering,
    which can be overcome by learning, whereas other mutations could have
    more pronounced effects, such as those involved in progressive disorders
    such as amyotrophic lateral sclerosis, or ALS.

    ========================================================================== Story Source: Materials provided by
    Oregon_Health_&_Science_University. Note: Content may be edited for
    style and length.


    ========================================================================== Journal Reference:
    1. Benjamin M. Zemel, Alexander A. Nevue, Andre Dagostin, Peter
    V. Lovell,
    Claudio V. Mello, Henrique von Gersdorff. Resurgent Na currents
    promote ultrafast spiking in projection neurons that drive fine
    motor control.

    Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-26521-3 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2021/11/211119085130.htm

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