Researchers identify brain signals associated with OCD symptoms, paving
way for adaptive treatment

Date:
December 9, 2021
Source:
Brown University
Summary:
The discovery of electrical signals in the brain associated with
OCD could enable an emerging type of adaptive deep brain stimulation
therapy as an improved treatment.



FULL STORY ==========================================================================
In an effort to improve treatment for obsessive compulsive disorder, a
team of researchers has for the first time recorded electrical signals
in the human brain associated with ebbs and flows in OCD symptoms over
an extended period in their homes as they went about daily living. The
research could be an important step in making an emerging therapy called
deep brain stimulation responsive to everyday changes in OCD symptoms.


==========================================================================
OCD, which affects as much as 2% of the world's population, causes
recurring unwanted thoughts and repetitive behaviors. The disorder
is often debilitating, and up to 20-40% of cases don't respond to
traditional drug or behavioral treatments. Deep brain stimulation, a
technique that involves small electrodes precisely placed in the brain
that deliver mild electrical pulses, is effective in treating over half
of patients for whom other therapies failed. A limitation is that DBS is
unable to adjust to moment-to-moment changes in OCD symptom, which are
impacted by the physical and social environment . But adaptive DBS - -
which can adjust the intensity of stimulation in response to real-time
signals recorded in the brain -- could be more effective than traditional
DBS and reduce unwanted side effects.

"OCD is a disorder in which symptom severity is highly variable over time
and can be elicited by triggers in the environment," said David Borton,
an associate professor of biomedical engineering at Brown University,
a biomedical engineer at the U.S. Department of Veterans Affairs Center
for Neurorestoration and Neurotechnology and a senior author of the
new research. "A DBS system that can adjust stimulation intensity in
response to symptoms may provide more relief and fewer side effects for patients. But in order to enable that technology, we must first identify
the biomarkers in the brain associated with OCD symptoms, and that is
what we are working to do in this study." The research, led by Nicole Provenza, a recent Brown biomedical engineering Ph.D. graduate from
Borton's laboratory, was a collaboration between Borton's research group, affiliated with Brown's Carney Institute for Brain Science and School
of Engineering; Dr. Wayne Goodman's and Dr. Sameer Sheth's research
groups at Baylor College of Medicine; and Jeff Cohn from the University
of Pittsburgh's Department of Psychology and Intelligent Systems Program
and Carnegie Mellon University.

For the study, Goodman's team recruited five participants with severe
OCD who were eligible for DBS treatment. Sheth, lead neurosurgeon,
implanted each participant with an investigational DBS device from
Medtronic capable of both delivering stimulation and recording native electrical brain signals. Using the sensing capabilities of the hardware,
the team gathered brain-signal data from participants in both clinical
settings and at home as they went about daily activities.

Along with the brain signal data, the team also collected a suite of
behavioral biomarkers. In the clinical setting, these included facial expression and body movement. Using computer vision and machine learning,
they discovered that the behavioral features were associated with
changes in internal brain states. At home, they measured participants' self-reports of OCD symptom intensity as well as biometric data --
heart rate and general activity levels -- recorded by a smart watch
and paired smartphone application provided by Rune Labs. All of those behavioral measures were then time-synched to the brain-sensing data,
enabling the researchers to look for correlations between the two.



========================================================================== "This is the first time brain signals from participants with
neuropsychiatric illness have been recorded chronically at home alongside relevant behavioral measures," Provenza said. "Using these brain signals,
we may be able to differentiate between when someone is experiencing OCD symptoms, and when they are not, and this technique made it possible
to record this diversity of behavior and brain activity." Provenza's
analysis of the data showed that the technique did pick out brain-
signal patterns potentially linked to OCD symptom fluctuation. While more
work needs to be done across a larger cohort, this initial study shows
that this technique is a promising way forward in confirming candidate biomarkers of OCD.

"We were able to collect a far richer dataset than has been collected
before, and we found some tantalizing trends that we'd like to explore
in a larger cohort of patients," Borton said. "Now we know that we
have the toolset to nail down control signals that could be used to
adjust stimulation level according to people's symptoms." Once those biomarkers are positively identified, they could then be used in an
adaptive DBS system. Currently, DBS systems employ a constant level
of stimulation, which can be adjusted by a clinician at clinical
visits. Adaptive DBS systems, in contrast, would stimulate and record
brain activity and behavior continuously without the need to come to
the clinic. When the system detects signals associated with an increase
in symptom severity, it could ramp up stimulation to potentially provide additional relief. Likewise, stimulation could be toned down when symptoms abate. Such a system could potentially improve DBS therapy while reducing
side effects.

"In addition to advancing DBS therapy for cases of severe and
treatment resistant OCD, this study has the potential for improving
our understanding of the underlying neurocircuitry of the disorder,"
Goodman said. "This deepened understanding may allow us to identify new anatomic targets for treatment that may be amenable to novel interventions
that are less invasive than DBS." Work on this line of research is
ongoing. Because OCD is a complex disorder than manifests itself in
highly variable ways across patients, the team hopes to expand the
number of participants to capture more of that variability. They seek
to identify a fuller set of OCD biomarkers that could be used to guide
adaptive DBS systems. Once those biomarkers are in place, the team hopes
to work with device-makers to implement their DBS devices.

"Our goal is to understand what those brain recordings are telling us and
to train the device to recognize certain patterns associated with specific symptoms," Sheth said. "The better we understand the neural signatures of health and disease, the greater our chances of using DBS to successfully
treat challenging brain disorders like OCD." The research was supported
by the National Institutes of Health's BRAIN Initiative (UH3NS100549
and UH3NS103549), the Charles Stark Draper Laboratory Fellowship, the
McNair Foundation, the Texas Higher Education Coordinating Board, the
National Institutes of Health (1RF1MH121371, U54-HD083092, NIH MH096951, K01-MH-116364 and R21-NS-104953, 3R25MH101076-05S2, 1S10OD025181) and
the Karen T. Romer Undergraduate Teaching and Research Award at Brown University.

========================================================================== Story Source: Materials provided by Brown_University. Note: Content may
be edited for style and length.


========================================================================== Journal Reference:
1. Nicole R. Provenza, Sameer A. Sheth, Evan M. Dastin-van Rijn,
Raissa K.

Mathura, Yaohan Ding, Gregory S. Vogt, Michelle Avendano-Ortega,
Nithya Ramakrishnan, Noam Peled, Luiz Fernando Fracassi Gelin, David
Xing, Laszlo A. Jeni, Itir Onal Ertugrul, Adriel Barrios-Anderson,
Evan Matteson, Andrew D. Wiese, Junqian Xu, Ashwin Viswanathan,
Matthew T.

Harrison, Kelly R. Bijanki, Eric A. Storch, Jeffrey F. Cohn,
Wayne K.

Goodman, David A. Borton. Long-term ecological assessment of
intracranial electrophysiology synchronized to behavioral markers
in obsessive- compulsive disorder. Nature Medicine, 2021; DOI:
10.1038/s41591-021- 01550-z ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/12/211209124247.htm

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