One autoimmune disease could lead to another
Scientists discover link between rheumatoid arthritis and other serious disease

Date:
January 4, 2022
Source:
University of Colorado Anschutz Medical Campus
Summary:
Researchers have discovered that having one kind of autoimmune
disease can lead to another.



FULL STORY ========================================================================== Researchers at the University of Colorado Anschutz Medical Campus have discovered that having one kind of autoimmune disease can lead to another.


==========================================================================
The scientists serendipitously found that mice with antibody-induced
rheumatoid arthritis in their joints went on to develop spinal lesions
similar to those in axial spondyloarthritis (AxSpA) which causes fusion
of the vertebrate and curvature, or bending, of the backbone.

The study was published today in the journal Immune Network.

"Our results suggest that one autoimmune disease, such as inflammatory arthritis, may also lead to a secondary autoimmune disease such as AxSpA,"
said the study's lead author Nirmal Banda, PhD, professor in the division
of rheumatology at the University of Colorado School of Medicine. "This interesting disease association may be due to the binding of anti-collagen autoantibodies to the spine, or to some alteration of the immune system
that requires further investigation." These same anti-collagen antibodies
are also present in humans with arthritis.

They directly attack joint cartilage resulting in inflammation and pain.

Banda noted that every mouse injected with collagen antibody-induced
arthritis (CAIA) developed arthritis and then curvature of the spine
consistent with axial spondyloarthritis.



==========================================================================
"I began to notice the proliferation of bone in the spine and fusing of
the vertebrate," he said. "The normal spaces between the spine vertebrate
in certain location were disappearing. This is similar to what happens
to humans with AxSpA." The connection, he said, has not been made in
any other study he's seen.

"I believe we are the first to make this link," he said.

But exactly how one autoimmune disease could trigger another remains a
mystery, one that Banda hopes to investigate.

"I want to know what the mechanism is," he said.

In the meantime, he suggested that those with an autoimmune disease be
vigilant in case they develop another.

"I believe because of our changing environment we are seeing a growth in autoimmune diseases," he said. "There are already connections between gum disease and rheumatoid arthritis and dry age-related macular degeneration
and rheumatoid arthritis. I believe this is an area that needs further exploration." The study co-authors include V. Michael Holers, MD,
professor in the division of rheumatology at the CU School of Medicine
and Francisco G. La Rosa, MD, professor in the division of pathology at
the CU School of Medicine.

========================================================================== Story Source: Materials provided by University_of_Colorado_Anschutz_Medical_Campus. Original written by
David Kelly. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. V. Michael Holers, Francisco G. La Rosa, Nirmal K. Banda. A
Potential New
Mouse Model of Axial Spondyloarthritis Involving the Complement
System.

Immune Network, 2021; 21 (6) DOI: 10.4110/in.2021.21.e45 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/01/220104123556.htm
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