COVID-19 increases risk of pregnancy complications, study suggests


Date:
February 7, 2022
Source:
NIH/Eunice Kennedy Shriver National Institute of Child Health and
Human Development
Summary:
Pregnant women with COVID-19 appear to be at greater risk for
common pregnancy complications -- in addition to health risks from
the virus - - than pregnant women without COVID-19, suggests a
new study.



FULL STORY ========================================================================== Pregnant women with COVID-19 appear to be at greater risk for common
pregnancy complications -- in addition to health risks from the virus --
than pregnant women without COVID-19, suggests a study funded by the
National Institutes of Health.


==========================================================================
The study, which included nearly 2,400 pregnant women infected with
SARS-CoV-2, found that those with moderate to severe infection were more
likely to have a cesarean delivery, to deliver preterm, to die around
the time of birth, or to experience serious illness from hypertensive
disorders of pregnancy, postpartum hemorrhage, or from infection other
than SARS-CoV-2. They were also more likely to lose the pregnancy or
to have an infant die during the newborn period. Mild or asymptomatic
infection was not associated with increased pregnancy risks.

"The findings underscore the need for women of child-bearing age and
pregnant individuals to be vaccinated and to take other precautions
against becoming infected with SARS-CoV-2," said Diana Bianchi, M.D.,
director of NIH's Eunice Kennedy Shriver National Institute of Child
Health and Human Development (NICHD), which funded the study. "This is
the best way to protect pregnant women and their babies." The study was conducted by Torri D. Metz, M.D., of the University of Utah, Salt Lake
City, and colleagues in the NICHD Maternal-Fetal Medicine Units Network.

It appears in the Journal of the American Medical Association. Additional funding was provided by NIH's National Center for Advancing Translational Sciences.

The study included more than 13,000 pregnant individuals from 17 U.S.

hospitals, approximately 2,400 of whom were infected with SARS-CoV-2.

Participants delivered between March 1 and December 31 2020, before
SARS-CoV- 2 vaccination was available. The researchers compared outcomes
among those with COVID-19 to those from uninfected patients, and tabulated
the study results as a primary outcome -- whether the patient had died
from any cause or had a serious illness or condition related to common obstetric complications. They also evaluated the results in terms of
several secondary outcomes, including cesarean delivery, preterm birth,
and fetal and newborn death.

Compared to uninfected patients, those with moderate to severe COVID-19
were more likely to experience the primary outcome, (26.1 vs 9.2%). They
were also more likely to deliver by cesarean (45.4 vs 32.4%) or preterm
(26.9 vs 14.1%) or to have a fetal or newborn death (3.5 vs 1.8%). Mild
or asymptomatic COVID- 19 was not associated with any of adverse outcomes.

========================================================================== Story Source: Materials provided by NIH/Eunice_Kennedy_Shriver_National_Institute_of_Child Health_and_Human_Development. Note: Content may be edited for style
and length.


========================================================================== Journal Reference:
1. Torri D. Metz, Rebecca G. Clifton, Brenna L. Hughes, Grecio
J. Sandoval,
William A. Grobman, George R. Saade, Tracy A. Manuck, Monica Longo,
Amber Sowles, Kelly Clark, Hyagriv N. Simhan, Dwight J. Rouse,
Hector Mendez- Figueroa, Cynthia Gyamfi-Bannerman, Jennifer
L. Bailit, Maged M.

Costantine, Harish M. Sehdev, Alan T. N. Tita, George A. Macones,
Melissa Bickus, Francesca Facco, Janatha S. Grant, Amy M. Leath,
Anna Bartholomew, Mark Landon, Kara Rood, Patrick Schneider,
Heather Frey, Amanda L. Nelson, Sean Esplin, Michael W. Varner,
Donna Allard, Janet Rousseau, Janet Milano, Lisa Early, Sabine
Bousleiman, Ronald Wapner, Desmond Sutton, Haley Manchon, Ashley
Salazar, Luis Pacheco, Shannon Clark, Hassan Harirah, Sangeeta Jain,
Gayle Olson, Antonio Saad, Lindsey Allen, Guillermina Carrington,
Jennifer Cornwell, Jennifer DeVolder, Wendy Dalton, Amanda Tyhulski,
Ashley Mayle, Suneet P. Chauhan, Felecia Ortiz, John M. Thorp,
Sally Timlin, Lena Fried, Hannah Byers, Jennifer Ferrara, Aimee
Williams, Gail Mallett, Mercedes Ramos-Brinson, Samuel Parry,
Meaghan McCabe, Christina Fazio, Anna Filipczak, Jennifer Craig,
Lucia Muzzarelli, Abigail Roche, Elizabeth A. Thom (deceased),
Crystal Nwachuku, V. Lynn Flowers-Fanomezantsoa, Monica Longo,
Menachem Miodovnik, Stephanie W. Archer. Association of SARS-CoV-2
Infection With Serious Maternal Morbidity and Mortality From
Obstetric Complications.

JAMA, 2022; DOI: 10.1001/jama.2022.1190 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/02/220207112715.htm

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