Discovery of new Hendra virus variant a lesson in emerging disease surveillance

Date:
February 24, 2022
Source:
University of Sydney
Summary:
New research has uncovered an unrecognized variant of the Hendra
virus, prompting re-evaluation of spillover risk from horses and
their carers to other humans.



FULL STORY ==========================================================================
A new variant of the Hendra virus has been identified by Sydney-led
research as a cause of fatal illness in Australian horses, and of risk
for virus spillover into humans.


==========================================================================
A second case of the variant was confirmed by the NSW Department of
Primary Industries near Newcastle in October 2021, using updated testing methods made possible by the research.

The story of its discovery serves as a case study on how ongoing disease surveillance programs are crucial to detecting emerging diseases.

Hendra virus circulates among flying foxes and is fatal to horses
and humans.

All flying-fox species in Australia are capable of being infected with
the virus and may transmit it to humans via spillover infection of
domestic animals. Flying foxes are a protected species, critical to our environment because they pollinate our native trees and spread seeds.

Flying foxes transmit the virus to horses via exposure to virus-laden
fluids such as urine when horses graze near or below trees with feeding
bats.

Since 1994 there have been seven human cases, four of which were fatal,
and all had been exposed to horses infected with Hendra.



==========================================================================
The researchers say the discovery demonstrates the importance of extensive biosecurity and surveillance programs that mirror the complexity of how
new viruses emerge.

This includes examining areas and scenarios where new viruses and emerging diseases are likely to come into contact with susceptible domestic
animal and humans, such as veterinarians. This is the foundation of the
'Horses as Sentinels' program, which led the detection of the new Hendra
virus variant.

"For a long time, there has been discussion among international
organisations about the need for co-operation across multiple research disciplines to monitor for any risks of emerging diseases, but this
is very hard to achieve," says lead researcher, veterinarian and
epidemiologist Dr Edward Annand, from the Sydney School of Veterinary
Science, Sydney Institute for Infectious Diseases , Faculty of Medicine
and Health, and the Department of Agriculture, Water and the Environment, Epidemiology -- One Health Section.

"This is an example that it can play out successfully- there is value
in bringing together a team with multiple perspectives, using their
strongest tools to improve disease surveillance." How to detect a new
variant Detection of the new variant was due to a seven-year effort to
create a network of frontline veterinarians, molecular biologists and virologists aiming to detect new viruses in domestic species, which has
been called the 'One-Health' network.



==========================================================================
This 'One Health' network also included United States-based
researchers. This allowed the researchers to share field and clinical observations and combine multiple laboratory techniques in parallel.

"This virus was different enough to avoid the established routine testing
and screening," says Dr Annand.

The researchers also found more than 93 percent of horses that were
tested for Hendra virus were in regions where spillover had previously
been detected (eastern Queensland and North-eastern New South Wales),
meaning there was reduced scope for detection outside these areas.

Dr Annand says there has been a general misconception that Hendra virus
cases only occur in these areas, and that has served as a barrier to investigating this disease.

The new variant was detected near Newcastle, central New South Wales and
it reinforces the need for broader testing -- including in all regions frequented by flying foxes.

"The good news is that the scientific findings support our understanding
that the current equine vaccine will be equally effective against this
strain, meaning reliable mitigation of human health risk is available
via immunisation of horses," says Dr Annand.

The research with these findings was published in Emerging Infectious
Diseases.

A virus detective story The new variant of the Hendra virus was found
in a laboratory sample from a Queensland horse that died an unexplained
death in September 2015.

Although the veterinarian suspected Hendra virus, routine screening
and diagnostic tests for Hendra were unable to confirm any diagnosis,
as they were designed to test for already known Hendra virus strains.

Samples from the Queensland horse were stored in a state laboratory,
alongside samples from horses that were routinely tested for disease.

"Instead of the samples being discarded after routine investigations, we partnered with the Queensland state biosecurity department to establish
a bio- bank and developed a system to screen using innovative tests for
known and unknown diseases," says Dr Annand.

In 2021, using Next Generation sequencing (a type of molecular testing
designed to detect unknown agents by extensively searching of genetic
material contained in a sample), the team confirmed the Queensland
horse's cause of death as a previously unrecognised Hendra variant.

The researchers alerted veterinarians and Australian laboratories and
drew on their collaboration with United States partners to confirm that
the current treatments would be equally effective in protecting against
the new Hendra virus strain.

The new Hendra variant is not the only novel spillover that the
collaborative team has uncovered. Previously, Dr Annand facilitated
detection of spillover of Australian bat lyssavirus to horses by
Queensland State biosecurity and CSIRO scientists. The Horses as Sentinels collaboration, led by the University of Sydney and Australia's national
science agency, CSIRO, grew from this experience.

"It's great to see this collaborative project make such an important
discovery which increases our understanding of the disease and the
distribution of Hendra viruses. This research has already made us
realise the importance of this type of work and the positive impacts
that it can have for protecting the health of horses and humans," says co-senior author Dr Ina Smith, from CSIRO.

========================================================================== Story Source: Materials provided by University_of_Sydney. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Edward J. Annand, Bethany A. Horsburgh, Kai Xu, Peter A. Reid,
Ben Poole,
Maximillian C. de Kantzow, Nicole Brown, Alison Tweedie,
Michelle Michie, John D. Grewar, Anne E. Jackson, Nagendrakumar
B. Singanallur, Karren M.

Plain, Karan Kim, Mary Tachedjian, Brenda van der Heide, Sandra
Crameri, David T. Williams, Cristy Secombe, Eric D. Laing,
Spencer Sterling, Lianying Yan, Louise Jackson, Cheryl Jones,
Raina K. Plowright, Alison J.

Peel, Andrew C. Breed, Ibrahim Diallo, Navneet K. Dhand, Philip N.

Britton, Christopher C. Broder, Ina Smith, John-Sebastian
Eden. Novel Hendra Virus Variant Detected by Sentinel Surveillance
of Horses in Australia. Emerging Infectious Diseases, 2022; 28
(3): 693 DOI: 10.3201/ eid2803.211245 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/02/220224112638.htm

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