New study offers insight on how resistance training burns fat

Date:
August 9, 2021
Source:
University of Kentucky
Summary:
Findings from a new study add to growing evidence that resistance
exercise has unique benefits for fat loss. Researchers found
that resistance-like exercise regulates fat cell metabolism at a
molecular level.



FULL STORY ========================================================================== Findings from a new University of Kentucky College of Medicine and College
of Health Sciences study add to growing evidence that resistance exercise
has unique benefits for fat loss.


==========================================================================
The Department of Physiology and Center for Muscle Biology study published
in the FASEB Journalfound that resistance-like exercise regulates fat
cell metabolism at a molecular level.

The study results in mice and humans show that in response to mechanical loading, muscle cells release particles called extracellular vesicles
that give fat cells instructions to enter fat-burning mode.

Extracellular vesicles were initially understood as a way for cells to selectively eliminate proteins, lipids and RNA. Recently, scientists
discovered that they also play a role in intercellular communication.

The study adds a new dimension to how skeletal muscle communicates with
other tissues by using extracellular vesicles, says John McCarthy, Ph.D.,
study author and associate professor in the UK Department of Physiology.

"To our knowledge, this is the first demonstration of how weight training initiates metabolic adaptations in fat tissue, which is crucial for
determining whole-body metabolic outcomes," McCarthy said. "The ability
of resistance exercise-induced extracellular vesicles to improve fat
metabolism has significant clinical implications." McCarthy's research
team was led by post-doc Ivan Vechetti, now at the University of Nebraska,
in collaboration with the Center for Muscle Biology, directed by Joseph
Hamburg Endowed Professor Charlotte Peterson, Ph.D.

Research reported in this publication was supported by the National
Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number R01DK119619.

========================================================================== Story Source: Materials provided by University_of_Kentucky. Original
written by Elizabeth Chapin. Note: Content may be edited for style
and length.


========================================================================== Journal Reference:
1. Ivan J. Vechetti, Bailey D. Peck, Yuan Wen, R. Grace Walton,
Taylor R.

Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van
Pelt, Ferdinand Walden, Bjo"rn Alkner, Charlotte A. Peterson,
John J. McCarthy.

Mechanical overload‐induced muscle‐derived extracellular
vesicles promote adipose tissue lipolysis. The FASEB Journal,
2021; 35 (6) DOI: 10.1096/fj.202100242R ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/08/210809144126.htm

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