Microbes turn back the clock as research discovers their potential to
reverse aging in the brain

Date:
August 9, 2021
Source:
University College Cork
Summary:
Research introduces a novel approach to reverse aspects of
aging-related deterioration in the brain and cognitive function
via the microbes in the gut.



FULL STORY ========================================================================== Research from APC Microbiome Ireland (APC) at University College
Cork (UCC) published today in the leading international scientific
journal Nature Aging introduces a novel approach to reverse aspects of aging-related deterioration in the brain and cognitive function via the microbes in the gut.


==========================================================================
As our population ages one of the key global challenges is to develop strategies to maintain healthy brain function. This ground-breaking
research opens up a potentially new therapeutic avenues in the form of microbial-based interventions to slow down brain aging and associated
cognitive problems.

The work was carried out by researchers in the Brain-Gut-Microbiota
lab in APC led by Prof John F. Cryan, Vice President for Research &
Innovation, University College Cork as well as a Principal Investigator
at APC Microbiome Ireland an SFI Research Centre, based in in University College Cork and Teagasc Moorepark.

There is a growing appreciation of the importance of the microbes in
the gut on all aspects of physiology and medicine. In this latest mouse
study the authors show that by transplanting microbes from young into old animals they could rejuvenate aspects of brain and immune function. Prof
John F. Cryan, says "Previous research published by the APC and other
groups internationally has shown that the gut microbiome plays a key
role in aging and the aging process.

This new research is a potential game changer , as we have established
that the microbiome can be harnessed to reverse age-related brain deterioration. We also see evidence of improved learning ability and
cognitive function." Although very exciting Cryan cautions that "it is
still early days and much more work is needed to see how these findings
could be translated in humans." APC Director Prof Paul Ross stated
that "This research of Prof. Cryan and colleagues further demonstrates
the importance of the gut microbiome in many aspects of health, and particularly across across the brain/gut axis where brain functioning
can be positively influenced. The study opens up possibilities in the
future to modulate gut microbiota as a therapeutic target to influence
brain health" The study was led by co-first authors Dr Marcus Boehme
along with PhD students Katherine E. Guzzetta, and Thomaz Bastiaansen.

========================================================================== Story Source: Materials provided by University_College_Cork. Note:
Content may be edited for style and length.


========================================================================== Journal Reference:
1. Marcus Boehme, Katherine E. Guzzetta, Thomaz F. S. Bastiaanssen,
Marcel
van de Wouw, Gerard M. Moloney, Andreu Gual-Grau, Simon Spichak,
Loreto Olavarri'a-Rami'rez, Patrick Fitzgerald, Enrique Morillas,
Nathaniel L.

Ritz, Minal Jaggar, Caitlin S. M. Cowan, Fiona Crispie, Francisco
Donoso, Evelyn Halitzki, Marta C. Neto, Marzia Sichetti,
Anna V. Golubeva, Rachel S. Fitzgerald, Marcus J. Claesson,
Paul D. Cotter, Olivia F. O'Leary, Timothy G. Dinan, John
F. Cryan. Microbiota from young mice counteracts selective
age-associated behavioral deficits. Nature Aging, 2021; DOI:
10.1038/s43587-021-00093-9 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/08/210809122202.htm

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