The synthesis of clonazolam was first reported in 1971. It was described as the most active compound in the series tested. Clonazolam is reputed to be highly potent, and concerns have been raised that it and flubromazolam:https://allcaredrugstore.net/
product/clonazolam-pellets/
may pose comparatively higher risks than other designer benzodiazepines due to their ability to produce strong sedation and amnesia at oral doses as low as 0.5 mg, or 500 micrograms (ug). It is reported to have a medium-length onset of action (20 – 60
minutes):https://allcaredrugstore.net/product/clonazolam-pellets/