"Spinal cord injury increases iron levels: catalytic production of hydroxyl radicals."
I was refused at the hospital when I asked for Minocycline, as the antibiotic in the attempted recovery, of someone with a spinal injury.
I asked them because of the iron chelating properties of the antibiotic, which was actively being tested in those wtih spinal injury.
In the animal model of the same injury, the injury is significantly relieved by bloodletting / 'iron reduction therapy'.
I believe first responders should target iron, in those with spinal injury. Prove me wrong.
Targeted Iron Chelation Will Improve Recovery After Spinal Cord Injury
https://pdfs.semanticscholar.org/7a4f/8367e62b59eccae8233df4613ff0d34dd54d.pdf
"Desferrioxamine (80 and 800 mg/kg body weight) significantly (p <.001) reduced the catalytic activity, suggesting that iron is the major contributor of the activity. Administering FeCl(3) (100 &mgr;M)/EDTA (0.5 mM) in ACSF into the cord through a
dialysis fiber significantly increased SCI-induced (*)OH production in the extracellular space, demonstrating that Fe(3+) can catalyze (*)OH production in vivo. Our results support that iron-catalyzed (*)OH formation plays a role in the early stage of
secondary SCI."
https://europepmc.org/abstract/med/12498980
Spinal cord injury increases iron levels: catalytic production of hydroxyl radicals. - Abstract - Europe PMC
Abstract: This study used a weight drop impact injury model to explore the role of iron and the reality of iron-catalyzed hydroxyl radical ((*)OH)...
europepmc.org
Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis
http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=3;spage=532;epage=541;aulast=Yao
Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis Yao X, Zhang Y, Hao J, Duan HQ, Zhao CX, Sun C, Li B, Fan BY, Wang X, Li WX, Fu XH, Hu Y, Liu C, Kong XH, Feng SQ - Neural Regen Res
Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair.
www.nrronline.org
"Minocycline Treatment Inhibits Lipid Peroxidation, Preserves Spinal Cord Ultrastructure, and Improves Functional Outcome After Traumatic Spinal Cord Injury in the Rat"
"Therapeutic outcome was coincident with more efficient iron clearance, suggesting that one possible mechanism whereby quercetin decreases secondary damage is through iron chelation"
https://www.ncbi.nlm.nih.gov/pubmed/12906742
Quercetin promotes functional recovery following acute spinal cord injury. -
https://pubmed.ncbi.nlm.nih.gov/12906742/
"Complexation of Flavonoids with Iron: Structure and Optical Signatures"
https://pubs.acs.org/doi/10.1021/jp076881e
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