A friend emailed this link today:

https://www.fda.gov/news-events/press-announcements/fda-approves-first-interchangeable-biosimilar-insulin-product-treatment-diabetes

Since the Medicare Donut Hole is killing me, I think I'll have my Doc change
my basal insulin back to Lantus from Tresiba. Then have the pharmacist substitute Semglee for Lantus. It may save money even if not in the formulary.

I used Lantus a few years ago. I thought it lower my dawn phenomenon by binding to IGF-1 receptors. But I was using 12U/day and at these low levels of insulin, it did not effect my Fasting Insulin Resistance Product (FIRP). The only concern is Lantus could cause the IGF-1 positive feedback loop that Humalog caused. So will have to watch for nocturnal hypoglycemic events
when using this new biosimilar insulin.

Tresiba is a special order item at my pharmacy. So not in stock. It is also too expensive, IMO, as it clobbers my Medicare Donut Hole.

So will probably change from Tresiba to Lantus next Doc appointment.
--
Jim
T1 4/86, no complications, watching for IGF-I positive feedback loop.
Nocturnal hypoglycemic seizures ended when stopped using Humalog (Lispro). Normal Dawn Phenomenon returned ~1 year later.

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Semglee basil insulin (estimated 15-to-35%
less expensive substitute for Lantus)

- - -
July 29 2021 https://www.pharmacytimes.com/view/fda-approves-insulin-glargine-yfgn-as-first-interchangeable-biosimilar-insulin-product-for-diabetes

July 28 2021 https://www.fda.gov/news-events/press-announcements/fda-approves-first-interchangeable-biosimilar-insulin-product-treatment-diabetes
- - -

Important Highlights:

o Insulin glargine-yfgn (Semglee) is biosimilar
to and interchangeable with insulin glargine
(Lantus), a long-acting insulin analog.

An interchangeable biosimilar can be substituted
for the reference product by pharmacists without
prescriber intervention.

o Biosimilars marketed in the U.S. typically have
launched with initial list prices 15% to 35% lower
than comparative list prices of the reference pro-
ducts.

o Note, already available, long-acting basil insulin
NPH, and short-acting bolus insulin Regular, at
Walmart, $24.99 each. Also newly available at
Walmart, short-acting bolus insulin Relion Novolog
insulin at $72.88 per vial (10 ml vial), the lowest
price ever for aspartame (analog) insulin.

IMPORTANT - NO ONE HAS TO DIE
FROM LOSS OF HEALTH INSURANCE
AND/OR LOSS OF JOB MAKING INSULIN
NON-AFFORDABLE, MANY HEALTHY
WAYS TO DEAL WITH THAT, AS SHOWN
ABOVE AND BELOW:

~~~

Low to No Cost Insulin may be available
via the following links:

Welcome to NovoCare® for Patient
Affordability and Access Support
https://www.novocare.com/

Lilly Cares® Foundation Patient
Assistance Program
https://www.lillycares.com/

Insulins Valyou Savings Program https://www.admelog.com/insulins-valyou-savings-program

Sanofi Patient Assistance Connection https://www.sanofipatientconnection.com/patient-assistance-connection

* * * * * * * * * * * * * * * * * * * * * * * * * * * * *

Pro-Humanist FREELOVER, I got Insulinitis
(Islit) which was caused by Insulitis at age 5
in March 1961, requiring multiple exogenous
insulin doses to try to stay alive. There are
15 specific types of rapid-onset Islit.

There is 1 specific type of slow-onset Islit,
Latent Autoimmune Islit, also unpreventable
& nonreversible (thus far).

- - -

Insulin / Insulin Pump / CGM I use

Fiasp Ultra-Fast-Acting Insulin in a
tubeless Omnipod insulin pump catheter
placed into skin / pod with adhesive
stuck onto skin every 80 hours, control
via PDM (Personal Data Manager) https://prohuman.net/pix2/Fiaspinsulin_tubelessOmnipodDASHinsulinpump.jpg

Dexcom G6 CGM (continuous glucose monitor) https://prohuman.net/pix2/Dexcom_G6_CGM.jpg

- - -

C.ure I.nsulinitis A.ssociation https://prohuman.net/cureinsulinitisassociation.htm

Glucose Anomalies Research regarding
Potential Cures / Improvements in Treatments https://prohuman.net/glucoseanomaliesresearch.htm

- - -

o Preventable Cellosis is the only specific
type of Disparate High Glucose Condition
that is preventable & reversible (in many,
sometimes it's called type 2 diabetes, often
confusingly called diabetes with no clarifier)

Risk for Preventable Cellosis, Hypertension,
& Cardiovascular Disease increases as one's
weight increases but BMI risk increases at
lower BMI levels in non-white individuals: https://prohuman.net/pix2/BMI-WaistCircumference-Cellosis&Hypertension&CardiovascularDisease-Risk.jpg
https://medicalxpress.com/news/2021-05-bmi-offs-obesity-diabetes-non-white.html

o PreCellosis (often confusingly called predia-
betes with no clarifier) is the oft-times preven-
table & reversible Cellosis precondition that all-
too-often the overwhelming majority having it
are unaware they have it

o 20 specific types of Cellosis, unpreventable
& nonreversible (thus far, sometimes called
type 2 diabetes, all-too-often confusingly called
diabetes with no clarifier)

Per the following article, 5.3% with Cellosis
used exogenous insulin in 2019. https://www.bloomberg.com/press-releases/2019-12-13/tandem-diabetes-care-announces-fda-clearance-of-the-t-slim-x2-insulin-pump-with-control-iq-advanced-hybrid-closed-loop

- - -

o 4 other Disparate High Glucose Conditions
exist (Gestational Cellosis, Diminosis, Neonatal
Diminosis, Ohiglucons), all 7 DHGCs fully des-
cribed in the following article:

Logic and reasoning behind ceasing using
confusing / misleading / misinforming diabetes
& diabetic & reactive hypoglycemia words and
phrases, replacing all of that with vastly superior
clarifying names:

Diabetes Bubble / Diabetes Bubble Burst https://prohuman.net/diabetesbubblediabetesbubbleburst.htm

* * * * * * * * * * * * * * * * * * * * * * * * * * * * *

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