screen a library:
From
Treon Verdery@21:1/5 to
All on Wed Mar 1 04:26:22 2023
radiolabelled or fluorophore labelled halogenated drugs, a few thousand, million, billion, or at a 300mm integrated circuit wafer with 1 trillion wells
Rapamycin, with like a trifluoro (methyl group like with three fluorines) that has 16 day or longer plasma half life, different plasma protein glomming could be an even more effective enhanced human longevity drug, from persisting at the circulatory
system longer; noting the mice that lived 60% longer from 126 ppm rapamycin had frequent meals but, I perceive I may have read, 9 minute rapamycin plasma half life, and I might have read human plasma half life of rapamycin might be .9 hours while
wikipedia says 57-63 hours; higher plasma protein glomming of a rapamycin; wikipedia says rapamycin is 92% protein glommed, there is some possible greater sustained rapamycin longevity effect there that could be produced and be beneficial; wikipedia
says, “ Since albumin is alkalotic, acidic and neutral drugs will primarily bind to albumin.”; Although a trained professional would know much more, the longest plasma half life of a drug I am aware of is norfluoxetine, 16 days, 384 hours; perhaps
the chemistry of such drugs (trifluoride like a methyl) could be used to produce even more beneficial, possibly even more longevizing variations of rapamycin, noting the mice were likely eating food perhaps every few minutes at the 126 ppm enteric coated
rapamycin dose; At the rapamycin molecule I read that a /\/\/\/\ with numerous \=/=\=/=\=/ is thought to be the mTOR active part of rapamycin, and it has a methyl on it that if replaced with a trifluoro methyl like moeity could cause the ten times
greater plasma half life. It is different than other things I have read, but wikipedia says ascorbic acid has a circulatory system half life of 83 days, with an eleimination constant of 4 months, that suggests something as simple as screening a variety
of locations of an ascorbic acid moeity could make a 3 month dose of a longevity producing rapamycin varaint; also I perceive I read that rapamycin’s oral absorption has to do with rapamycin’s nonsensitivity to pH, a rapamycin ascorbic acid version
could have higher effective drug absorption at a particular mg or ppm at food dose;
--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)
From
Treon Verdery@21:1/5 to
All on Wed Mar 1 04:42:34 2023
radiolabelled or fluorophore labelled halogenated drugs, a few thousand, million, billion, or at a 300mm integrated circuit wafer with 1 trillion wells
Rapamycin, with like a trifluoro (methyl group like with three fluorines) that has 16 day or longer plasma half life, different plasma protein glomming could be an even more effective enhanced human longevity drug, from persisting at the circulatory
system longer; noting the mice that lived 60% longer from 126 ppm rapamycin had frequent meals but, I perceive I may have read, 9 minute rapamycin plasma half life, and I might have read human plasma half life of rapamycin might be .9 hours while
wikipedia says 57-63 hours; higher plasma protein glomming of a rapamycin; wikipedia says rapamycin is 92% protein glommed, there is some possible greater sustained rapamycin longevity effect there that could be produced and be beneficial; wikipedia
says, “ Since albumin is alkalotic, acidic and neutral drugs will primarily bind to albumin.”; Although a trained professional would know much more, the longest plasma half life of a drug I am aware of is norfluoxetine, 16 days, 384 hours; perhaps
the chemistry of such drugs (trifluoride like a methyl) could be used to produce even more beneficial, possibly even more longevizing variations of rapamycin, noting the mice were likely eating food perhaps every few minutes at the 126 ppm enteric coated
rapamycin dose; At the rapamycin molecule I read that a /\/\/\/\ with numerous \=/=\=/=\=/ is thought to be the mTOR active part of rapamycin, and it has a methyl on it that if replaced with a trifluoro methyl like moeity could cause the ten times
greater plasma half life. It is different than other things I have read, but wikipedia says ascorbic acid has a circulatory system half life of 83 days, with an eleimination constant of 4 months, that suggests something as simple as screening a variety
of locations of an ascorbic acid moeity could make a 3 month dose of a longevity producing rapamycin varaint; also I perceive I read that rapamycin’s oral absorption has to do with rapamycin’s nonsensitivity to pH, a rapamycin ascorbic acid version
could have higher effective drug absorption at a particular mg or ppm at food dose;
--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)