Wikipedia says there are 47 HAR genes. Putting all 47 of these HAR genes in one mouse at $2k per gene is about $100k, and then making 8 clones is about another 16K. 8 clonal mice is sufficient to calculate a p value at .05 So it looks like there is an
experiment that could be done for near $120k that could see if mice live three times longer, something near the 2019 AD human 2019 AD primate difference. The numbers are approximate but if they are order of magnitutude plausible then it is less than 1.2
million $.
If it works on the mice the popularity and awareness of longevity technology could go up if zoo animals were genetically engineered to live three times longer as well. https://www.fightaging.org/archives/2009/06/significant-single-gene-longevity-
mutations-in-humans-what-are-the-odds/#comment-37059

straw genetically engineered to make latex rubber might be more waterproof.

Lithium supplements could be longevity drugs: Hence, we used a typical model organism for anti-aging studies, C. elegans, to test whether low-dose Li+ levels similar to those observed in some areas of the Oita prefecture, i.e. 10 μM, may actually cause
reduced mortality. Based on previously published evidence from the Lithgow laboratory, a 1000-fold higher concentration extends C. elegans

1000 times 59 ug is 5.9 mg, so 5.9 mg dose

LiCl has been previously shown to extend life span of a model organism for anti-aging studies, the roundworm Caenorhabditis elegans, when applied at high, i.e. non-nutritional doses of 5 mM and above [11]. However, drinking water Li+ concentrations in
the Oita prefecture ranged from 0.7 to 59 μg/L only [8], the latter equaling a concentration of 8.5 μM. Hence, we have continuously exposed several hundreds of C. elegans in separate experiments to 1 and 10 μM LiCl, respectively. We found mortality in
populations exposed to 10 μM of LiCl to be decreased (p = 0.047) (Fig. 1b),

noting that lithium at 1000 times the concentration of the water supply of some humans during 2018ish causes c elegans to live more than 30% longer, making GRAS food and additive ingredients that c9ontain lithium could be beneficial. It is possible that
any food additive with a measured nonoptimal wellness effect could be mnade into a beneficial form with lithium chemistry. So using lithium nitrite and lithium nitrate instead of sodium nitrate and nitrite and sodium proprionate could be a longevity
producing preservative. It is possible that as many chemicals during the 20th century just used a sodium salt as the cheapest to prduce variety there are many common food additives that are sodium salts, which if changed to lithium salts would cause
longevity effects at many foods. Notably lithium, to my perception causes a longevity heightening effect at a two or even possibly three orders of magnitude dose variations suggesting unspecified amounts of lithium from nonmeasured sources would have a
longevizing effect.


An actual biologically active drug that causes the plaebo effect to gho up 100%. is it ethical?

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