liposome formulations showed a mean diameter in the range of 175 nm to 219 nm with polydispersity index lower than 0.22, a lightly negative zeta potential and excellent encapsulation efficiency. Moreover, along with good mucoadhesive properties,
multifunctional liposomes showed a markedly increase in tacrine permeability, which can be related to liposome fusion

with cellular membrane,



C-Pc liposomes were more effectively taken up by Neuro2a cells than free C-Pc and were biocompatible, maintaining the anti-oxidative properties of C-Pc. When optimal C-Pc liposomes were administered to middle cerebral artery occlusion (MCAO) rats 2 h
after onset, infarct sizes were smaller and behavioral activities improved compared with the same metrics in free C-Pc-treated rats. Liposomal delivery still reduced infarct sizes and improved behavioral activity 6 h after onset, whereas free C-Pc did
not.



Intranasal liposomes had a longer half-life in the brain than intranasally or orally administered free drug



Piperine is an antidepressant works better as a snortable liposome, “Antidepressant and cognitive effects of piperine-en- capsulated liposomes (PL) were investigated in male Wistar rats. Oral piperine (5 mg/kg body weight/day) and intranasal PL (7.2 μ
g/day) were randomly as-signed to daily administer for 14 days to rats which were subjected to forced swimming, Morris water maze and spontaneous motor behavior tests. PL sig-nificantly exhibited anti-depression like activity and cognitive enhancing
effects, in comparison to the con-trol groups after the first dose (p < 0.01) and the ef-fects could be maintained throughout the period of study. Quantitative analysis of the brain homogenates by HPLC indicated that piperine, delivered either orally or
nasally, distributed to the hippocampus at a higher extent than the cortex and that the time to peak concentration of nasal PL was shorter than for the oral piperine. Intranasal PL was, thus, potential in delivery of piperine, at a low dose, to exert its
an-tidepressant and cognitive enhancing activities.”

siRNA drugs can be administered with liposomes, “ntranasal delivery of the siRNA targeting Beclin1 significantly depleted the target protein expression levels in brain tissues with no evidence of toxicity.”



we developed a nose-to-brain delivery system combined with cell-penetrating peptide (CPP), Cell-Penetrating Peptides (CPPs), also known as protein transduction domains (PTDs), membrane translocating sequences (MTSs), and Trojan peptides are short
peptides (≤40 amino acids), with the ability to gain access to the interior of almost any cell. They are highly cationic and usually rich in arginine and lysine amino acids. They have the exceptional property of carrying into the cells a wide variety
of covalently and noncovalently conjugated cargoes such as proteins, oligonucleotides, and even 200 nm liposomes.



melatonin antidepressants, mood elevators exist, “Agomelatine is a structural analog of melatonin”, it is possible that like tyhe pineal peptide AEDG causes greater longevity molecular variations of these mood improving drus could be simulataneously
longevizing and mood improving, “agomelatine. Agomelatine is a melatonergic agonist and a 5HT2c antagonist (i.e., it has a unique mechanism of action). The melatonergic function appears to improve sleep patterns, whereas the serotonergic antagonism
results in the release of norepinephrine and dopamine.”



Previously described is finding the genetics of having good dreams, I favor making the genetics of having good dreams part of the human germline, also, amount persons above the 99th percentile of longevity they could find those at the 99% of having
actively good dreams and an absence of dreams the person would prefer to have skipped, this is a guide to finding the genetics of more beneficial sleep, it may even be possible that there are those at the 99th percentile of longevity who dream twice as
much as others, dreaming good dreams twice as often is beneficial to humans and is beneficial to make a part of the human germline



g (like IQ) gene “klotho-enhanced mice performed better on a variety of learning and memory tests, regardless of age. In one test, the mice remembered the location of a hidden target in a maze better, which allowed them to find it twice as fast as
control mice.”

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