then advertise to talk to a babysitter, and ask if you can do her overflow or when she is not available, possibly 7-3 during school year. Pay her a comission for every hour of babysitting that occurs, and have her collect the money and give it to her
favorite charity, with her reserving her comission out of the earnings.



Longevity technology:



fisetin is a senolytic. tyrosine sulfate is not metabolized by the liver. It is possible although unknown to me that fisetin sulfate could possibly be senolytically active while having a long sustained plasma half life as, like tyrosine sulfate it
would be gradually excreted as urine. I do not know if sulfates pass through exterior cytomembranes or pass epithelial cytes, it is possible that putting an enzymatically dividable linker molecule like a ribose, a two mer (unit) peptide or even a acetyl
link like the one at sucrose that goes between the dextrose and fructose between the sulfate part of the molecule and the fisetin part of the molecule could cause much greater plasma half life, but be able to have the fisetin separate to be an active
senolytic at the cytoplasm because of enzymes endogenous to the cyte’s cytoplasm; as a possible localization opportunity it is possible that some kinds of cytes have very different endogenous enzyme concentrations or types than other cytotypes, so the
long plasma halflife version of fisetin would cause fisetin sulfate to soak in all over the body with a multi hour or even multi day plasma half life and only divide from its sulfate at the linker site at a particular kind of cyte with the right enzyme,
perhaps a deacetylase or an aminoacidase. Or an opportunity: if the linker molecule is ribose, NR, NMN or something like coenzyme Q10, then it is possible the amount of enzymatic activity at the cyte will be directly related to the number and activity of
the mitochondria at that cyte: localizing fisetin to high mitochondrial number or also high mitochondrial metabolic output could concentrate a senolytic at a particularly active tissue, localizing the senolytic effect



fisetin palmitate or dasatinib palmitate as a super long plasma half life senolytic, palmitate depot drugs last, I perceive as long as 3 or 6 months from one injection, so compared with what might be a 1 hour human plasma half life at fisetin the fisetin
palmitate would be at active drug strength for 4320 hours, so 3 orders of magnitude longer lasting senolytic activity. Palmitates possibly just attaches a C16cooh to some part of the fisetin or dasatinib (dasatinib actually has an ethyl with an -oh on
the distal part that might be replaceable with a C16cooh as kind of similar from my uninformed perspective) or another senolytic, the fisetin might still work as quercetin looks like fisetin and is one -OH different and some other -OHs are like a
different angle of para on a benzene, and quercetin kind of works as a senolytic, noting dasatinib with quercetin published effective senolytics.



longevity technology:



So, noting magnesium sulfate (epsom salt) makes the blood brain four times less permeable should I take it because phenylethylamine blood pressure effect raises my blood pressure and because pressurized osmotics at the blood brain barrier? I could even
just take it the day of phenylethylamine



It would be nifty to find out if magnesium sulfate had an effect on placenta permeability, if it does it could be a mass production veterinary drug that possibly benefits mammal fetuses, imaginably 1-2 per 100 mammals. a thing from wikipedia supports
magnesium sulfate as a possible well pregnancy drug, “Magnesium sulfate is effective in decreasing the risk that pre-eclampsia progresses to eclampsia.[11] IV magnesium sulfate is used to prevent and treat seizures of eclampsia. It reduces the systolic
blood pressure but doesn't alter the diastolic blood pressure, so the blood perfusion to the fetus isn't compromised.”



The four times less permeability at the blood brain barrier along with the blood pressure reduction makes me think that magnesium sulfate (epsom salts) could reduce the risks of phenylethylamine, but, this onlinbe thing says it is only 2 units, “people
receiving a median of 368 milligrams (mg) of magnesium a day for an average of three months had overall reductions in systolic blood pressure of 2.00 millimeters of mercury (mm Hg) and diastolic blood pressure of 1.78 mm Hg.”



Dose: “intramuscularly (6 g loading dose followed by 2 g/h)” oral constipation dose, “2 to 4 level teaspoons dissolved in 8 ounces water orally

-Repeat dose in 4 hours if needed.

Maximum dose: 2 doses per day”



a million cytes processed in a few hours (2015 AD), “The "µ" stands for the microcapillary glass slide that holds the protein samples. The slide is roughly the size and thickness of a penny, yet in that space a million capillary tubes are arrayed like
straws, open on the top and bottom.

The power of µSCALE is how it enables researchers to build upon current biochemical techniques to run a million protein experiments simultaneously, then extract and further analyze the most promising results.”, “The slide bearing these million yeast
or bacteria, and the protein variants they produce, is inserted into the µSCALE device. A software-controlled microscope peers into each capillary and takes images of the biochemical reaction occurring therein.”

a different system does 100k yeast per second, or 10 seconds to process one million yeast, “To show the system’s utility, we demonstrate high-throughput image-based screening of budding yeast and rare breast cancer cells in blood with an
unprecedented throughput of 100,000 particles/s” https://www.pnas.org/content/109/29/11630

when using a million yeast to see if any of the protein parts of something like a 200 year old rockfish’ tissue causes yeast to live longer it is possible that the

It is possible that yeast engineered to produce more fluorescent protein each 24 hours could be detected as to their lifespan with the very oldest yeast producing the most fluorescence, then you would just coat a freeze fractured, possibly freeze dried
micropowder of a 200 year old rockfish’ tissue or a freeze dried freeze fractured sample of filtrate from seawater with the fluorescent yeast, and wherever the camera detected a one per million yeast longevity event the eentsy portion of freeze dried
freeze fractured tissue the yeast was on could be isolated, and the chemicals and proteins in it characterized to find proteins, peptides or other chemicals that caused the one per million yeast longevity event. It is possible that if 11 to 100 yeast
grow on each microfragment of the biological library of rockfish tissue or ocean water filtrate then the yeast could be isolated while alive and measured as to things like the mRNA or other cytoprocesses that caused them to be unusually long lived. The
blob of longevity chemical releasing tissue could also be dug out of the array to find and show the organism or sample that caused the longevity effect at the yeast.

Numerous longevity technologies at the notebooks make use of screening a library for new longevity producing molecules, noting the 1 million yeast screened per 10 seconds a camera system that finds and isolates the most fluorescent, from having lived the
longest, yeast seems possible

.

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