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It might be possible to create a drug that causes a narrow 5 minute period of blood brain barrier, gonad brain barrier, or placenta as barrier activity window for administering a beneficial drug. Attaching a moeity that the liver is really avid about
chemically modifying could do it, Also it seems kind of primitive, but a person could be immunized against a cytomembrane transport molecule that is rare and does not occur endogenously, then a blood brain barrier permeability causing drug, like some
bacterial products or piperine is attached to the antigen, the antibodies might be able to clean it up out of the circulation in less than 3 minutes, noting that there is actually an immunization against cocaine which pre-empts the mental effects of
cocaine just from durably circulating antibodies. I have no idea how this could possibly work as 100-300 mg of cocaine seems like it would require 1-3 grams or much more of the much larger AMU antibody to be circulating, and glom onto the cocaine before
it reached the brain; technologically though it suggests it is possible to have a 3 minute window of high blood brain barrier, blood gonad barrier, or placenta high permeability.

Also, variations of the blood brain barrier, possibly correlatable at human genetic SNPs and then genetically modifiable at laboratory mammals to test hypotheses about things like: at a group of well persons, such as supercentenarians, with 99th
percentile of blood brain barrier form both among the supercentenarians which would be compared with the population of children’s blood brain barrier permeability;

Noting that a combination of epithalon which is similar to a pineal product and thymosin causes humans to be 4 times less likely to be nonalive after 6 years and that the thymus and pineal are absent being filtered with the blood brain barrier it is
possible that the brain or cerbrospinal fluid secretion tissues produce other chemicals that would benefit the body. The pituitary has a blood brain barrier filter between it and the circulatory system, I am without any idea what would happen without a
blood brain barrier filtration of exported pituitary chemicals.

Notably however measuring the amount of permeability of the blood brain barrier at supercentenarians could come up with data that supercentenarians have 90th percentile or higher of blood brain barrier minimal permeability, which suggests a genetic basis
of supercentenarian physiology that can be made available to everyone with blood brain barrier permeability reducing drugs as well as gene therapy and also germline modification.

Noting measurements of supercentenarians, a published paper says magnesium sulfate causes the blood brain barrier to be 4 times less permeable, and if blood brain barrier permeability has a quantified beneficial effect on longevity, wellness, and
healthspan then magnesium sulfate supplementation could be a longevity drug.

Also as a possibly longevity wellness parameter what is the permeability of the blood brain barrier at children and teenagers, it is possible that permeability is more optimal for people post-teens.

Screening a cerebrospinal fluid library to find longevity molecules: compare and find uniques among the different molecules and concentrations of a screenable library of same, shared, or chronological age unique molecules at teens and children with those
of supercentenarians: are there different chemicals or different amounts? Does chemical, supplement, or drug administration, gene therapy, or genetic SNP variation increase longevity, wellness, and cognitive function when supercentenarian CSF is
modified to be like that of children?

It could benefit babies to have blood pressure in the 1th to 32th percentile, (just imagining that 1 standard deviation less of osmotic and blood pressure stress could benefit babies; also do babies experiencing some emotions or even thoughts then have
measurable blood pressure “skyscrapers”? If they do is there a nootropic wellness promoting blood pressure reducer; the sweet sugar-OH mannitol reduces intercranial and ocular pressure, tastes good, and might be harmless as well, Although I perceive
babies get lots of loving touch and often experience music it is possible more of these things could benefit babies; it is also possible a laser based blood pressure monitor could measure the blood pressure of babies, if it happens to matter, and alert
the parents, again, if it matters), “the blood–brain barrier (BBB) was still immature in newborns. This was due to an error in methodology (the osmotic pressure was too high and the delicate embryonal capillary vessels were partially damaged). It was
later shown in experiments with a reduced volume of the injected liquids that the markers under investigation could not pass the BBB”

Blood or CSF of schizophrenics is published as terminating the lives of rodents while that of well humans is harmless; so do other nondisease mental states have an effect on rodents like people at 99.9th percentile IQ, g heighten cognitive function at
laboratory mammals, also people at the 99th and 1st percentile of each of the big 5 psychology test areas, are also sampleable and testable: also identical twins where one watches a movie with a particularly strong and frequent emotion and the other
omits watching a movie; if the rodents behave differently when the blood, plasma, or cerebrospinal fluid of the humans is injected into them they could use that as a basis to create beneficial new drugs from screening the blood, plasma, or CSF for
chemicals that effect cognitive capability, particular emotions, or various big 5 measures. Drugs based on those could be beneficial: a big five conscientiousness heightening drug would be a kind of voluntary successtropic, agreeableness could assist
those that felt they should make more friends or felt socially isolated or wanted better dating frequency and experience, although openness to experience might be more effective at making people more fluent at contacting potential dates and actually
dating. Noting that being in a romantic partner relationship is correlated with wellness, and I think I read longevity, openness and seeking out of partners and romance as well as sex is beneficial. It is also possible to administer the blood, plasma,
and CSF fluid of people at the 99th percentile of sexual activity and sexual thoughts, of all sexes, to laboratory mammals as well as human volunteers and quantitatively measure mental contents at intervals, quantifying the amount and intensity of sexual
thoughts, feelings, and emotions with a thing like experience sample monitoring (ESM) as well as measuring the amount of actual sexual activity increase at the body fluid receivers to quantify the effects of the physiological chemistry of the persons
that think about sex and have sex more often than 99 out of 100 people; noting that sexual activity is a strong predictor of partner relationship well being, as well as sex being a popular thing, new drugs based on the unique or heightened physiological
chemicals of people at the 99th percentile of sexual thoughts and actual frequency of sexual activity are beneficial to people.

Research on circulating biochemicals, noting the published difference at schizophrenics, could create new mental wellness medications that reduce mental emotional and perspective nonoptimalities: blood, plasma, or cerebrospinal fluid from the minimal 1th
percentile of big five personality test neuroticism, when administered to rodents or human test volunteers and who then have quantifiable reductions in their own big 5 neuroticism measures support the creation of new mental wellness drugs as well as
create possibilities for immunizations that increase mental wellness from the immuneocytes glomming any nonoptimal circulating chemicals, other drugs and medications to heighten mental wellness include gene therapy or (likely) protein-drug producing
probiotics.

GSK: making the two cycle dental hygiene technology even more functional: Another likely harmless thing that could be a cycle at a two or three cycle gingivitis and periodontitis preventer and breath scent odor-precluder could be the protein-lytic
molecules known as proteases.

Some enzymes that digest proteins that are already mass produced are things like trypsin and pepsin, notably these are harmless if digested.

Proteases might work especially well with gum as the gum lasts at the mouth a few minutes and is plausibly delicious and used a few times every 24 hours. Also with gum it is imaginable that the person might chew 3-11 pieces of a delicious gum each 24
hours, and if each piece of gum had a different protease or other proteolytic enzyme they could get several cycles of harmless-to-humans, fully stomach digested bacteriocides each 24 hours.

It is possible all the gum could have the same delicious flavor, but if there were flavor differences then it could be at like a 3 or 7 different flavor pack like peppermint/ juicyfruit/ wondermint/ "fruit stripe".Two_20cycle_20dental_20hygiene#1563706436



Transcytosis at blood brain barrier technology: Getting drugs past the blood brain barrier: “coating of polyalkylcyanoacrylate or poly-lactic-co-glycolic acid (PLGA) nanoparticles with polysorbate 80 or poloxamer 188. Due to this coating the particles
adsorb apolipoproteins E or A-1 from the blood and thus interact with the signalling protein LRP1 or with the scavenger receptor followed by transcytosis across the blood–brain barrier into the brain.” something like this transcytosis transported
drug coated with a coating that accumulates transcytosis chemicals from the circulatory system on its exterior could possibly provide beneficial transport of beneficial chemicals or drugs past the blood-gonad barrier as well as the placenta, to heighten
fetus and baby wellness and heighten perinatal measures (like weight, APGAR, and possibly placental size and possibly also other fetus and baby attributes as well as maternal physiological chemistry measures) that predict life activities, wellness, and
capabilities above the 50th percentile of 2019 AD humans generally. Although I think genetics determines personality and capability, optimizing fetal and perinatal baby wellness could move the median of babies, and the fully grown people they become,
up to the 60th percentile on average among those receiving better than well fetal, maternal, and perinatal baby medications.



GSK: Olfactory enjoyment chemicals, it is possible that there are chemicals active at parts per trillion that could cause other things to smell nice, screening a library of molecular variants of trichloroanisole (TCA), which wikipedia says, “The odor
of TCA is not directly perceived. Instead, the molecule distorts the perception of smell by suppressing olfactory signal transduction.[2]” https://en.wikipedia.org/wiki/2,4,6-Trichloroanisole ; The effect, which at TCA is not a scent people enjoy,
could be modified from screening a library of TCA molecular variants to find variants that cause other things to smell pleasant; the TCA olfactory effect occurs at very low concentrations (single parts per trillion), so even very minute amounts of TCA
can be detected. these moleular variants that are screened as a library to find versions that cause olfactory enjoyment could possibly be an ingredient in deodorants or antiperspirants as the parts pre trillion effect could pass through garments and
cause even the slightest lingering scent to become enjoyable to a person near the person using the chemically new deodorant or antiperspirant, it could also be a pheremone sensitizer, possibly causing human attractant pheremones to be much more potent.
Also, at parts per trillion this could cause perhaps almost all humans worldwide to smell better at likely 1 cent a year or less. Further, it is possible that one person at a few hundred square meters could make all the humans at that area smell nice,
and things like public transport, the homeless, and shelters could be olfactory modified to smell pleasant with a novel kind of air freshener.

Wikipedia says of an opiate peptide: “Casomorphin is a heptapeptide and could be able to pass the BBB”, also as previously noted Pro-Gly (noopept) concentrates at particular areas of the brain.

Reducing PEA use to 2 days a week, “According to New Scientist, 40 percent of individuals treated with a combination of vigabatrin and counseling remained abstinent from [a stimulant]



MWI: some MWI articles suggest I am actually asleep, as that is one of the unitary MWI kinds of occurences; at some of those I wake up, of course the ones where I wake up to a high fidelity version of what happened during my actual life, perhaps as a
sleep walking P-zombie would be there as well.



MWI technology:

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