Fifty‐three lifespan experiments, involving 30 test agents, have been initiated in the first 11 years of the ITP. Significant effects on longevity, in one or both sexes, have been published for 6 of the tested agents: aspirin (Strong et al., 2008),
nordihydroguaiaretic acid (NDGA) (Strong et al., 2008; Harrison et al., 2014), rapamycin (Harrison et al., 2009; Miller et al., 2011, 2014), acarbose (ACA) (Harrison et al., 2014), methylene blue (Harrison et al., 2014), and 17‐α‐estradiol (17aE2) (
Harrison et al., 2014).



17‐α‐estradiol (17aE2)

Beginning at 10 months of age, male and female mice were fed chow containing 17aE2 at a concentration of 14.4 ppm (17aE2). As shown in Table 1 and Figure 1, median lifespan increased 19% in male mice, calculated from data pooled from the three sites (P <
0.001). The effects of 17aE2 were significant at all three sites, at P < 0.003, with increases in median survival of 26%, 9%, and 23% at TJL, UM, and UT (Fig. S1, Supporting information). The age at which 90% of the mice had died increased on average by
12% (21%, 8%, and 8% at the three sites;

dose: 14 ppm in mouse food, or .014 Grams per Kg of food, it is unknown how much food mice eat every 24 hours. It is possible they eat 5g of food every 24 hours which would be a human dose of 2333 mouse measl per human per day, or 11.665 Kg of food
equivalent aE2 per human, or 163.3 mg of 17aE2 per human per day, or with mouse compensation number, 13.6 mg aE2 per day

17aE2 is at alibaba.com



Rapamycin with metformin: Males given Met/Rapa had a 23% increase in median longevity

food: 14 ppm rapamycin, 1000 ppm metformin

163.3 mg of rapamycin per day for a human, with mouse compensation number, 13.6 mg per day at a 70 kg human.

1000 mg per kg, 30 gram mouse, 5 grams of food every 24 hours is 11.66 grams of metformin per human, with mouse compensation number, .972 grams of metformin per day per human.



NDGA: Nordihydroguaiaretic acid (NDGA)

In a previous study, we tested the effects of NDGA on survival of male and female UM‐HET3 mice at a dose of 2500 ppm and reported that median lifespan was increased in males by 12%, with no benefit in female mice (Strong et al., 2008). In the earlier
study, 9% of male control mice were alive at the joint 90th percentile age, compared with 13% of NDGA‐treated males (P = 0.12).

Acarbose (ACA)

Beginning at 16 months of age, mice were fed chow containing 1000 ppm ACA. The results are shown in Figure 6 and Table 2 with site‐specific statistics in Table S3 (Supporting information). Pooling the data across sites, there was a significant increase
in survival for male mice treated with ACA, with a 6% increase in median lifespan and a significant 12% increase in maximal lifespan

a peptide: https://interestingengineering.com/12-innovations-that-could-make-reverse-aging-a-reality “testing pNaKtide, a synthetic peptide that could further reduce risks of illness and the effects of aging.”, “The study saw researchers
successfully reverse the biological state of the brain in mice aged 12 months and 18 months. The test mice were treated with THC in small, non-intoxicating doses for a period of four weeks. They were noted as out-performing the control group who had been
given a placebo, and were shown to have similar cognitive performance to younger mice. This could mean that non-intoxicating THC treatments might allow older humans to regain youthful levels of cognition.”

Two days before July 27th, 2019

A drug that makes people more big five psychology test: conscientious (kind of like myers briggs J) could be a drug that causes greater success are various kinds of things, a successtropic. Some social efforts could be replaced by prescribing mentally
well people in the bottom 30th percentile of doing well successtropics to voluntarily take. One possibility is looking at the fMRI and positron emission tomography of people at the 90th percentile of doing well and seeing if they have more or different
activity at various locations and many different kinds of neurons and neurotransmitters. It could be brain system activation thing as well though, so perhaps computer software or virtual reality could do it.

Acarbose is published as causing 9 or 10% longer lifespan in mice at 1 part per 1000 in mouse food, wikipedia says that it is produced as several versions at one pill, “WHere was the structure for acarbose sourced? I think the stereocenters might be
wrong. I have a feeling it was sourced on PubChem. There are MULTIPLE acarbose structures on PubChem. See here. The think the correct stereo is as shown here oChemSpider. However, this is my opinion and it needs confirming. Help.--ChemSpiderMan (talk) 00:
30, 25 January 2008 (UTC)

Yes, I used PubChem as a source at the time. I'm not sure of the stereochemistry; as you just said, help :) Fvasconcellos (t·c) 00:57, 25 January 2008 (UTC)

The information from Bayer is here it seems its sold as a mixture of anomers” So perhaps just one of the versions is more active at causing longevity.



It was pleasant to find out that liposomes transport things inside them to the lympathic system, where they have more biological activity that going to the liver through a vein, “Lipid-based nanoparticles

(formulation-derived)

Administration of a single capsule of long-chain lipid can stimulate significant lymphatic transport of drugs.

- Solid lipid nanoparticles

- Self-nanoemulsifying drug delivery systems

- Emulsion

- Liposomes

- Effective carriers for drugs

- Stimulators of chylomicron production

The effect of the formulation on drug absorption and lymphatic transport is less clear.



“

liposomes like senolytics might be makeable with phosphatidyl choline and or as well as lecithin at $24.98 magnasonic ultrasonic cleaners on ebay. could up dose of dasatibin, rapamycin, acarbose, others. Some use 35 kHz to make liposomes, magnasonic is
42 kHz

There is something called phosol Some phosol might be 25-75% phosphatidyl choline, with MCT (like coconut oil), sunflower oil, safflower oil, propylene glycol. Mayo clinic fisetin study was “For oral administration of fisetin, mice (“At 85-weeks of
age (>20 mth), male and female mice were administered a diet containing 500 ppm (500 mg/kg) fisetin[fisetine mice live to 125 weeks, non-fisetin live 105-110 weeks without fisetin) were dosed with 100 mg/kg of fisetin in 60% Phosal 50 PG:30% PEG400:10%
ethanol” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/ at humans that is 100 mg *70, or 7 grams per dose, or using the mouse compensation number, 583 mg per human dose.

Also as to length of treatment, the Mayo clinic dose is two consecutive days, but this paper has mice going from 6 to 14 weeks, with two two week doses during that time (6-8 weeks and 12-14 weeks) and greater than halving their messed up cytes from the
two groups of two weeks of treatment during that that 8 week interval; https://www.ebiomedicine.com/article/S2352-3964(18)30373-6/fulltext The mice get 500 mg/Kg, 35G/24 hours or with mouse compensation number 2.91 g/24 hours, so at a human for 2 weeks
that would be 14*2.91 or about 41 grams, or 82 grams for the two 2 week dosage events. A different procedure at the same paper has 100mg/Kg for five days reducing markers of nonoptimality going to 1/3 of 1/5 of the untreated mice and having values
similar to those of young mice. With mouse compensation this goes from 7g a day for 5 days to 583.3 mg/24 hours for five days



I think phosphol was used at the Mayo clinic 1.4 G per day, 2 day with 10% ethanol. so ultrasonic liposomes with 75% phosphatidyl cholone and 5% ehtothol or 10% ehtanol might work. Make different versions of liposomes and then use microscope at the
marine life center to verify they actually are liposomes.

This describes making liposomes with ultrasonics: https://www.quantumbalancing.com/liposomalC.htm

At ascorbic acid it says it goes from 19% absorbed to 93% absorbed with the liposomal effect.

Weird new fruit: An apple with lots of layers of skin at its interior, or a grape with many layers of skin: I perceive I have seen vegetable or fruits with interior versions of the same fruit in them. Apple polyphenols cause 10-12% greater longevity in
c elegans and drosophila, and 43% reduction in human mortality at a correlation study, so a delicious fruit that was like 14 layers of outside skin could be a one fruit (like an apple) that has 14 times the longevity and wellness benefit from fruit
polyphenols (like an apple); One way to make this taste more optimal is to increase the sweetness, wikipedia mentions a beneficial polyphenol, “ingested phlorizin is converted into phloretin” as well as “Phlorizin is a white to yellow crystalline
solid with a melting point of 106–109 °C. It is of sweet taste”, so just breeding fruit (like apples) to have more phlorizin could make them taste better as well as possibly heighten wellness, although the benefits from eating apples. as published,
are much less than those from concentrated apple phytochemicals. Still, 14-40 times more skin at polyphenol containing fruits from nesting layers from new bred varieties could have concentrate like effects from one fruit.

Also, with genetic engineering the apples could make sweetness peptides at the skin and cortex making it more delicious than regular fruits (like apples) “Treatment with apple polyphenols extended the life span of natural C. elegans by 12%.1 As with
the previous experiment with apple polyphenols, activation of sirtuins’ calorie restriction-mimicking effects was evident.”, “apple polyphenols have been shown to extend by 10% the life span of the fruit fly, D. melanogaster, another commonly-used
model of human biological processes and aging”, also “those who consumed the largest amounts of flavonoids (found in apples and other fruits) were shown in one study to have up to a 31% reduction in total mortality.9, 10 When intake of apples
specifically was examined, that study showed as much as a 43% reduction in death from heart attacks specifically.”, “Animals fed apple polyphenols had up to a 17% reduction in the size of atherosclerotic lesions found in their arteries” https://www.
lifeextension.com/magazine/2012/4/Apple-Polyphenols-Longevity/Page-01

Phlorizin reduces some glucose things “phloridzin inhibits glucose uptake by 52%” functioning sort of like metformin or acarbose, it causes mice and humans to be skinnier, and is cardiobeneficial

Apple polyphenols are available at ebay, $17.17 22.5 grams as 125 mg and 180 pak pills. one research dose, “adults were given 600 mg/day of apple polyphenols”

Making dimers with electric plasma, “Nonthermal dielectric barrier discharge (DBD) plasma-induced structural changes in dihydrochalcone phloridzin (1) resulted in the isolation of three new methylene-bridged dihydrochalcone dimers” So, does this
work on a bunch of other polyphenols and glucosides (things with a glucose moiety) So perhaps plasma dimerized fisetin might be as or more effective than fisetin.

Million or hundred million sample mass screening of libraries of chemicals for longevity drugs: screen libraries of possible sources of new longevity drugs with libraries of chemicals from wild fungi, blenderized bugs that have been given cancer with
radiation, other blenderized inertebrates, blenderized plant tumors and galls, filtered material from ocean water and freshwater; use the published million capillary tube microfluidic sample tester I read about and possibly the yeast enumerating
cytoenumerator I read about that images 100,000 yeast per second of 6 million yeast per minute, 360 million yeast an hour.

To find the longest lived yeast, genetically engineer yeast to make more cumulative GFP (green fluorescent protein) or BFP (blue fluorescent protein) the longer the yeast live, then yeast that go through the imager and have the brightest fluorescence are
the longest lived.

A microfluidic million yeast array, that has living colonies, part of which are sampled or characterized automatically for longevity, from utilizing fluorescence imaging, and have the rest of the yeast available and alive for culturing as well as array
location findability to find the chemical that makes the yeast live longer are produced at a 1000 times 1000 grid, made from things like integrated circuit technology, laser ruling of a yeast nutrient gel, or microfluidic system fabrication technologies
like that used to produce the million capillary array.

microfluidics or just floating a layer of material atop the array grid places things from the library being screened onto the gel; Lasers then energetically comminute half or a third of the array location’s unique library material. I have seen
holographic diffraction gratings for lasers where something like a .5 mm beam is divided into many hundreds of bright dots at a patttern. With a more powerful laser, and a custom holographic diffraction grating filter, several hundred or even thousand
little point beamlets can be produced. then with a powerful enough laser these beamlets are strong enough to pop open a plant tissue fragment, some fungal cytes, (sort of like laser disintegrating a surface), popping open a library fungi blob, or
comminute just part, like a third of a marine filtrate organism. This is all done at the surface material lying on the nutrient gel, or just possibly the laser comminutes and pops a third of a library item just a few micrometers under the nutrient gel
surface. The laser could also warm the array spot with the blob it has just comminuted 1/3 of, to get the chemicals in the comminated material to diffuse rapidly through the gel, so that when yeast grow on it’s surface the yeast will be affected by
the diffusion of the chemicals from the popped cytes of the library. One benefit of a using a laser, raster scanned, or holographically microbeamed to pop library samples is that after the yeast colonies coating the upper side of the gel react to the
comminuted diffusive material with greater longevity, a 2/3 remaining sample of the original library material can be scooped up to provide a sample of the organism or part of it, that causes the longevity effect. If you are screening a library of fungi,
and the array item has a 70 times 70 micrometer bunch of hyphae under a micrometer of gel, and the laser comminutes and warm-diffuses a 20 times 20 micrometer area of the hyphae, if those fungal chemicals cause greater longevity then there is enough
remaining hyphae to find out what, and which chemicals, caused the increased longevity at that array element location. Similarly for 90 times 90 plant tumor fragments with 20 times 20 areas of laser comminution and warmth based diffusion.

Along with lasers, zapping some of a sample and leaving enough to identifity what it is, when as a library item it causes greater longevity; other methods like freeze fracturing as well as autolysis of library tissues are other methods of modifying
things at the library, on the array, to release their chemicals for the yeast to respond to as they grow.

Freeze fracturing or inducing autolysis (“The general method for making yeast extract for food products such as Vegemite and Marmite on a commercial scale is to add salt to a suspension of yeast, making the solution hypertonic, which leads to the cells'
shrivelling up. This triggers autolysis, wherein the yeast's digestive enzymes break their own proteins down into simpler compounds, a process of self-destruction.”) notably where the autolysis chemical is harmless to yeast, possibly isotonic with
dilution or addition of a buffer, produces items to be in the screened library (like the many organism ocean or feshwater filtrate, sonicated, possibly autolysed bug or plant, or fungi goop) produces availablized chemicals, notably cytoplasmic chemicals,
that are then microfluidically moved or pumped onto the yeast nutrient gel array to make a diffusive gel layer, then a rinse of live yeast on that layer to grow colonies. A flourescent laser and camera (possibly raster scans or better) looks at the
million colony array and finds the array items with the brightest GFP, then those chemicals that caused the greater longevity are looked up (the array has a numbered row column reticle), and those are items from the library that are things that can be
genetically engineered into other organisms to make sufficient amounts to medicate c elegans and mice for further longevity studies.

There are different, I think better ways of mass screening libraries of longevity chemicals at my paper notes which are likely to be imaged and on this website.

Finding new variations on longevity chemicals and drugs with greater effectiveness: have microfluidics deliver the drug to a microreactor such as a microfluidic binomat, with 11 different sequential reactions based on catalytic, enzymatic, or reagent
binomat pegs, and 100 to 10,000 base collector channels, resulting in 11 factorial different reactions the initial chemical experiences, producing 399 million different chemical variants. The microfluidics transport these to million location yeast arrays.
So you put acarbose or rapamycin among many possible drugs or chemicals, as well as those from screened libraries in the top of the binomat, and have it react, or be catalyzed 1 to 11 times sequentially altogether with things like Co, lithium aluminum
hydrate, trypsin, iodine metal, pepsin, hydroxylase, hydrogenase, cycle-opening (<=> —> \/\//) as well as others; notably if highly affordable reactants and catalysts are used at the binomat then the chemical production of those drug variants amongst
the 399 million are particularly affordable to make and the chemical engineering could favor simpler scale-up and possibly STP reactions, resulting in less manufacturing cost. I have seen an image of a fluidic binomat online; also it is possible to use
two or three binomats with 3 or 4 reactive, catalytic or enzymatic pegs each then feed the result of one binomat into another to make the 399 million variant 11 catalytic, enzyme, as well as reagent pegs. If the published 360 million yeast optically
screened per hour technology is up to it then 3 billion chemical variants can be screened in 10 hours, at the billion item array of colonies, Also possible is the laser raster scan and camera to look for the most fluorescent yeast among one billion array
items at planar array. At 6 micrometers diameter per yeast, then an array 31623 locations on a side is just 32 millimeters on a side where each array item contains 100 yeast per colony. A larger 1000 yeast per colony at the array is 197 millimeters on
a side, which goes well with 200 mm integrated circuit wafer technology.

Wikipedia says 1500 varieties of yeast have been given species names. Screening a library of yeast could find yeast that naturally live 10 times longer or more than Saccharomyces cerevisiae, the genome of those yeast could be investigated to find out if
there are proteins or other chemicals at those longer lived yeast that function as longevity drugs as well as find genetic sequences at the yeast that make mice live longer.

A liquid fungal growth medium could be poured repeatedly on soil at perhaps 14 different global locations, the soil dug up, then the soil samples mixed with 40 times volume of growth medium, then then the multiple new fungi containing culture medium
could be used at a library screening array, likely without isolation of particular species. If it is possible to give fungi cancer with radiation then screening a million or a billion of the chemicals the yeast produce while treating cancer could
produce new longevity chemicals (noting senolytics) as well as new anticancer drugs.

New antibiotics and anticancer drugs: The 11 factorial binomat as well as the most fluorescent live longest, which also goes with the dead ones being least fluorescent could also be used to find new antibiotics and anticancer drugs. If rather than yeast,
infectious bacteria were grown at a gel medium at a million or billion location array, then binomats or freeze fractured or autolysed screenable libraries could find or make those chemicals and proteins that variously kill bacteria, oncocytes at human
tissue culture, or cause them to cease bacterial cytodivision. Another variation on this is that the million or billion item array could be microfluidically exposed to carcinogens to cause 1-10% cancer at human tissue culture cytes at the array, then
amongst that 10 to 100 million oncocytes that occur at locatable array locations, compare those locations at a different array, where an anticancer library is screened. That screens 10-100 million possible anticancer and well as cancer preventative
chemicals; this is more efficient if the first array is only as large as the number of published carcinogens (10,000?) and then these carcinogens, possibly multiplexed, are placed at all the locations of the million or billion item array which then
screens a million or a billion different possible oncotherapeutic drugs and anti cancer drugs and even new cancer preventing drugs.

Screening a library of human tissues: Human tissues, particularly those at well supercentenarians, 80 year old cadavers, kindergarten age children, and teenagers could be autolyzed or freeze fractured, or possibly (although I think there are better
things than electrophoresis) electrophoresisized then differentially described and the unique per-age (children, teens, supercentenarians) chemicals quantized with electrophoresis or some other technique, to find out which electrophoresis protein bands
were absent in children that were in cadavers, and those protein bands that were in cadavers that were absent from supercentenarians. This would provide a library, the entirity of all the diferential chemical bands from electrophoresis, of possible
longevity and youthfulness heightening proteins to screen as a library. There is also the possibility to find out which chemicals and proteins to minimize: chemicals unique to 80 year old cadavers’ tissues and blood, that, if immunized against, could
cause greater longevity, as they are what the children and supercentenarians do not have circulating or have being produced.

The idea is to use actual human tissue as a screenable chemical and protein and ion library to find and identify longevity and wellness chemicals using a million or billion item array to see the effect of those endogenous human chemicals. One benefit of
screening human tissues and blood, as a library, is that the chemicals and peptides and proteins found have direct applicability and drug utility to human longevity, wellness, and healthspan.

Finding the optimal cadavers to compare the supercentenarians and kindergarteners with: it is possible there is already published research on what otherwise well 20th century persons biochemistry and blood chemistry anomalies were during the year before
those 20th century AD persons without cardiovascular disease or cancer died? That noncardiovascular disease, noncancer biochemistry that preceded death by 12 months during the 20th century may be known, or if not, can be figured out. …Perhaps persons
that died from pneumonia, flu, kidney illness, accidents and respiratory illness;

“Chronic lower respiratory diseases: 149,205”

At my paper or computer notes, I think are a bunch of repiratory technologies like lung probiotics (possibly including harmlessized beneficial proteus that migrates and produces beneficial peptide or protein drugs), a new one: enzyme-limited dose asthma
and other medications, no matter how much you inhale the dose remains the same as it is caused by (turned into functional drug with) enzymes or as a hydrated drug possibly from the thickness of mucous coating, or a new one, senolytics that can be inhaled,
perhaps at age 40, 50, 60, 70, 80, 90, 100, 110, 120, 130 and up. liposomal antivirals might be of benefit as well.

Inhaleable gene therapy or probiotics that make growth factors like EGF or VEGF might make a difference, They could blend growth factors until they found something that caused the number of alveoli that spontaneously grow to increase (imagine 50-100%),
then administer the therapy to only one lung at a time. Medical improvement of one lung at a time could give people time to heal, and utilize scar-dissolving things, if they exist, along with longevity and beauty peptides, I read there are beauty
peptides that increase elastin, and some dissolve scars, “Clinical studies have found that copper peptides remove damaged collagen and elastin from the skin and scar tissue because they activate the skin's system responsible for those functions.”
These things could be used to remodel one lung at a time,

Noting that neurons that make the most of the lung capacity a person has could be amplified as to their function with nootropics it is possible inhaled nootropics or oral nootropics could benefit people with COPD.

It is possible that hormesis could benefit people with COPD, possibly causing some tissue regenration, one possibility is that lipopolysaccharides could be the hormetic agent, notably which bacteria that the LPS are made from, and the particular mass
fractions of the LPS can be the fresh area of drug research producing patentable material, also benefitting people globally, a LPS inhaler used perhaps 3-11 times, once every few months is likely pretty cheap. There is some mention of LPS at hormetic
online, other things that are hormetic like perhaps imitation of light septic shock and things that stress the endoplasmic reticulum. tunicamycin is described as a neurologically beneficial endoplasmic reticulum hormetic chemical https://www.frontiersin.
org/articles/10.3389/fncel.2018.00222/full

Dubious yet plausible: Make sports quiz phone apps for each of 5 teams in any state, then at 50 satetes that is 250 clone-like sports quiz apps, globally that is like 3 billion divided by 300 million (US) so 2500 clonal sports quiz apps; the sports quiz
apps could have things on how to cease inhaling things that cause COPD, including camp smoke; the sports quiz apps could also have information on how to be a better parent, and even suggest being a better parent could go with children experiencing less
smoke of every kind, and possibly gently urge financial generosity towards women and children. At 10,000 people downloading each sports app then that is 2.5k times 10k or 25 million app users, if 1% of them minimize smoke exposure successfully then that
is 250,000 people with less risk of COPD. 500,000 if 10 sports teams per 5 million people can be made into quizzes.

Mist makers like nebulizers might be improved with better nozzles, enzyme or hydration activated drugs that cause the same identical beneficial dosages at lung depth or nearer the throat based on enzymatic activity production (and near throat drug
absorption reduced to optimal dose); Practice at optimal inhaling of drugs in front of a computer could be beneficial.

Could a virus engineered to produce a beneficial blend of growth factors like EGF and VEGF reach all the alveoli of a one-treated-lung at a time? The concept is that existing alveoli might make more bulbish things.

possibly a hydrophilic protein that rapidly gets degraded so it omits making gooiness could contain active drug, but only release as much drug as there is water surrounding it, suggests finding out what enzymes are at the pulmonary mucosa; perhaps there
is a pulmonary ciliary protein that is quite hydrophilic on its own, even puffing up with water but hypoallergenic and immunoneutral. Put that on the outside of imitation liposomes, like liposomes without lipids, with a diffusive drug core; It could be
like a ratioized blend of surface flavored jello mixed with gradual flavor diffusion jello to deliver multiple hours of steady plateau-like drug activity.

It is possible that something that increases the number of erythrocytes causing more oxygen absorption with less inspired air could benefit people with COPD; I think I have heard of erythropeotin to make more erythrocytes, and it is possible a new drug
could be developed that causes erythrocytes to be recycled every 180 days instead of every 120 days rising the amount of oxygen carrying capacity at the circulatory system 50%.

Noting the fractal nature of the lungs could a combination of postively and negatively charged inhaler nozzle droplets or inhaleable powder reach different areas of the lungs? It seems like no, as drifting mist, or even powder, positively or negatively
charged onto water will cause particulate or droplet wetting.

peculiar, but could an effervescent inhlation possibly like Xenon gas pop rocks, cause faster drug delivery from mucous stirring during fizz?

Could muscle building things like creatine benefit the diaphragm, or even SARMS or anabolic steroids to build up musculature at the lungs?

Perhaps a prescriptionless inhaler that only does people good could be of benefit.



I feel perhaps I misunderstand, but this website says that 37,000 people in the US died near 2018 from accidental poisoning, more than vehicle accidents, so globally that is near 720,000 people. Perhaps people’s phones could have an app that tells
people what something is, and if they should avoid it. Online it says unintentional misuse of prescription drugs is a part of poisoning numbers. It might be possible to have a deep learning AI and a wall-mounted camera watch people grabbing pills in
the bathroom and alert them if something looks dangerous.



Online it says the 9th of 10 leading causes of not being alive during approximately 2018 AD was kidney disease.

Notably though, as compared with diagnostic tissue and blood chemicals it is possible that there are specific chemicals, which if there were less of them, would increase human longevity. Kidney disease might cause a bunch of chemicals to build up in the
circulatory system, and some of these could actually be harmful, so treating that chemical symptom could actually cause greater longevity and healthspan. One possibility could be immunizing against those built-up chemicals.

So, wikipedia describes numerous things about kidney unwellness, so is there a wellness kidney function that is at the 99th percentile of wellness, and does it have any healthspan or longevity benefits? Edema, peeing out protein, and those peed out
proteins leaving the rest of the body with nonadequate function (like anticlotting something-opposite-thrombin, or other things),

So is there a highly functioning, highly capabable kidney function profile? Is it genetic? Can kidney function be not just restored but brought nearer to optimal at a median person to make it so they are 99th percentile optimized for wellness and
longevity kidney function. It is possible growth factors like EGF, VEGF, others could be linked to localizer molecules to generate more, better, or histologically like youth morphology at the kidney.

Causing dialysis to actually increase longevity: people with kidney diseases, wikipedia says, excrete different amounts of protein and other circulating chemicals. It is possible that dialysis membranes that have novel affinities or chemical exclusions
could increase longevity and healthspan. One possibility, linked to longevity and sulfur containing amino acids, is to preferentially remove methionine, or inteleukins, although wikipedia says that peeing out lots of protein is a thing that happens with
some kidney disease.

Particulalry to increase the wellness of children, liposomal corticosteroids could be orally effective, “minimal change disease that has a remission rate of 95% with corticosteroids”




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