Investigating Neurotransmitters and Partnered Longevity Effects
From
Julia Amara@21:1/5 to
All on Wed Jul 12 15:22:16 2023
. This could possibly be made into a gene therapy for humans to have, possibly along with just less or no atherosclerosis, but if if atherosclerosis were to occur it would be the bowhead whale kind.
Tortoises (400 year lifespan) and bowhead whales (over 200 year lifespan) might get pneumonia, at up to 400+ years, how do these organisms
CPP to lungs from circulatory system brings anti-pneumonia drugs, and possibly mucolytics preferentially to lung tissue,
I think I read that some nonhuman organisms that maintain the same mate decline if their partner organism ceases living, trace this to any of 100 different neurotransmitters and possibly even EEG effects, then come up with a better than well and
partnered neutrotransmitter booster drug to test as a longevity technology to see if it causes greater longevity
There is some kind of thing where mountain and prairie voles partner up or do not partner up, but can interbreed, measure to see if they have differences in survival after partner nonaliveness; if they do, then figure out the difference in the longer
lived variety to find out the mechanisms of precluding partner mediated deleterious lifespan effects, and find the biochemistry of better than partnered longevity effects.
LKM512 yogurt is published at about 2 studies as causing 80-90% lifespan increase in mice; give LKM512 yogurt to atherosclerotic mice to see if it causes greater longevity even with a non-cancer atherosclerotic mouse model
there is a DNA methylation thing called an epigenetic clock, I think may others must have alreaddy considered editing this clock as a way to increase lifespan. could the corpse of a superenteneratian, 99.999999% of the cytes as which, or more are still
fully functional, extend or refute the methylation clock? Or find the places on it it, the actual tissues, that matter (neurons, vasculature)
its not cancer, its point of specificity tissue disregulation (hints of epigenetic clock going amiss at .000000000001% of tissue causing say atherosclerosis
genetically engineered-in anti-ischemia harm peptides as testable longevity drugs at atherosclerotic mice
mouse dorm n=40k, what causes a bruise to be scavenged successfully away, rather than treated as a body interior multicm dead tissue that could float out and cause strokes effect?
do the genetics of least bruising have any relation to cardiovascular wellness genetics? IS there any relation to longevity effects? Least bruising of human MZ twins correlates with what wellness benefit?
volunteer process, ultrasonic zapper bruises 1 cm tissue at 100k human volunteers with parents ages 70 on up. Correlate parental survival and lifespan with child non bruisability, advantage, basically harmless to the 40-50 year olds at experiment.
Pills that stop bruising may be longevizing, there may be a reduction of “microetherosclerotic” effects benefit as well.
“In one study, patients suffering from pigmented purpura — those deep purple bruises that get progressively worse — that took 50 mg of rutin (oral rutoside) two times per day along with 500 mg of Vitamin C twice a day were completely healed of
their bruising within just four weeks.”, “hesperidin can dramatically reduce bruising and strengthen your capillaries”
60 second reactive stent, 20 seconds better
f=MA microsurgery, 2mm golfball core elastics can do 1.8 mm suturing at 90% mechanical engineering efficiency.
just explore the HOX and other state space to find completely well nonhuman primates with 2-3x the volume, span, and reach, of coronary arteries as regular primates, verify they are almost immune to lethal cardiovascular events from network and path
duplication at the corononary vasculature.
should they just put in two hearts?
right handed heart people
apoe e immunue to ath at germline
Ok, so the source of tissue culture can be exceptionally well tissue, it is even possible that exceptionally well tissue with its epigenetic meythylation clock reset to age 1 could be the basis of transplant tissue.
One way to tell excpetionally well tissue culture tisuue is to use the velvet plate cuplication process; a tissue culutre plate with say 1 billion cyctes at it (vascular epithelium, or better, stem cells) is velvet copied, then the copy frozen (or
quiecently maintained), then at the 1 billion cyctes on the source plate actual particular to the human physiological stressors are introduced.
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