Perfumed Antibodies for Cancer Detection
From
Lina Dash@21:1/5 to
All on Sun Jul 16 08:40:12 2023
technologies that treat, prevent, cure and or also diagnose cancer ultraffordably (cheaply) notably at the developing world, where the technologies are also functional at the developed world:
perfumed antibody that are an an enteric pill or a snortable cheap think like a drink mix stick pak: 16 for 1$, so 7 cents a snort.
A "fizzy tic tac" is a tic-tac sized diagnostic pill shaped thing that you can put in a container of pee. The idea is that it is a cheap to make as a tic-tac or possibly cheaper. The oter layer has a nonreactive coating, and just underneath it is a
layer that fizzes to dissollve like sodium bicarbonate and a harmless organic or polyprotic acid that dissolves away a coating layer to reveal the imunno color changing stripe, shape, or stripes printed on an inner surface.
A "perfumed antibody" is an antibody attached to a chemical that has unique high detetability at minimal solute amount at another antibody test such as a circulatory fluid or pee immunochemical test like the ones in dollar store pregnancy tests; this
test would also have higher resolvability with greater ability to distinguish between what I describe as "perfumes" when mentioning the different chemicals. One kind of perfumed antibody could be a unique polypeptide or even artifical amino acid peptide
that is linked to the antibody that gloms biologically available chemicals or even biostructures; the perfumed antibody might work even better at seperating when glommed from having an enzymatically degradable linker molecule between the antibody and the
perfume, one possible version is antibody:ATP:perfume where the ATP, or one of its phosphates pops off when the antibody gloms onto something.
hyperaffordable antibody tests for cancer (or heart disease) based on $1 dollar store pregnancy test; pregnancy test has three lines, about 7 mm tall. If only one of the lines has antibody-reactive colorant at it then an antibody test with a 1 mm
indicator view can be seven times cheaper, or 15 cents a test, more niftier is the version if all three lines at a dollar store pregnancy test are immunoreactive colorized; then there are 21 linear mm of antibody indicator material, which produces 21
cancer antibody tests per dollar, or about 5 cents a cancer diagnostic test.
personality test
perfumed antibodies liberate the perfume when they glom, and then the perfume, which might be linked to, or part of, a molecule that heightens excretion at the kidneys, is particularly easy and accurate to detect at an antibody pee test. So if an
antibody gloms to a acancer site at any place in the body the antibody releases the perfume, which shows up at the antibody pee test; noting the math of false positives
senolytic cancer chemotherapeutics cause an effect where even if you get a flase positive (developing, if you test positive fr cancer, just take the senolytic chemotherapy pills; the cancers being tested for are preferentially, or only the kind that can
be cured with pills, so the ill person gets to skip the doctor, the hospital, and skip the costs, just getting the pee test and the senolytic optimized chemotherapy pills. Becasue the chemotherapeutic drug is also a senolytic if you take it for 2 or 3
weeks with a false positive diagnoses, then the senolytic function mkaes you live years longer and be weller anyway, and of course for some that test positive it cures their cancer.
si rna
siRNA or other RNA drugs, like cancer treating or curing chemotherapeutic drugs can be structured to last longer or less long at the circulatory system, it seems possible that a chemotherapy drug that just lasts 45-120 minutes could terminate oncocytes
rapidly instead of gradually, and only be felt as a chemotherapeutic experieince for a few minutes; that brings up the opportunity to have a comuter linked to an automatic dosing machine, even one at the person’s dwelling, figure out when the person
was completely asleep, in deep sleep, and likely to keep sleeping; then the dosing machine would dose the person with the siRNA or other RNA drug, and all of the acute feelings from the chemotherapy drug would go unexperienced, and the person would feel
ok instead; there is a version of this that is better than dosing while asleep: doctors or online software or phone apps could give people a psychiatry quiz or survey that then estimates, at 95% likelihood or higher, that they have a nonaddictive
personality. If they have only a 1 per 20 or less chance of craving a euphoria inducing drug or chemical after they end treatment then the patieint can be given MDMA or benzodiazepenes to take for the duration of the siRNA (or other RNA drug)’s
duration of action. The person experieincing chemotherapy would feel wonderful.
It is possible there are senolytic siRNA or RNA drugs, if so, some variations on those siRNA or other RNA senolytics could be modified to there is[anticancer|senolytic] physical structure possible at liniear si RNA or other RNA drugs, and at branched
siRNA or RNA drugs then the branches can each have a different drug effect at that branches RNA, so perhaps a ratio of three senolytic RNA branches to one highly effective antioncocyte RNA branch; thats a way to tune the senolyticness and anticancerness
of the siRNA or other RNA drug.
oncocytecytoreproduction disrupting IPMAT active siRNA or other RNA drugs could disrupt the cytoreproductive cycle, affecting dividing oncocytes more than well tissue
pure siRNA or RNA drugs could be produced at yeast, bacteria, or plants making them decentralized and ultraffordable at the developing owrld.
Cheap, easy to make chemicals approximate the anticancer effects of fluorouracil: wobble uracil; Mg,Ca, Sr, Ag, P uracil versions where the uracil molecules contain a Mg or Ca, or Ag or P atom. Some of the atoms are +2 or -2 electrons so the modified
uracil might come as a two-uracil, one Mg or one Ag dimer, or you could just stick a hydrogen on it or something to make a nonionizing water soluble molecule. Notably magnesium aspartate and magnesium threonate exist, and that is an amino acid linked to
a magnesium, magnesium threonate crosses the blood brain barrier to be a beneficial nootropic, so MgUracil could be functional at passing the cytomembrane of oncocytes.
along with uracil, anticancer drugs could also be based on the other RNA amino acids, adenine, cytosine, and guanine. So wobble or extra atom versions of any of these could be anticancer drugs.
Ag uracil might be cytotoxic as when the uracil is incorporated into the oncocytes RNA the metal ion at the amino acid completely modifies the shape of any polypeptide, ribosome, or transcription string it is part of, a little like having a halogen atom (
like at fluorourcil) disrupt all kinds of cytothings, only with a metal atom that is very cheap to mass produce. There is the possibility that things like Mg-uracil could be produced at bacteria that just had lots of Mg at their growth media, something
that would not likely work with halogen atoms.
wobble uracil is where a ultraffordable source of uracil, like a yeast or bacteria, even a modified beverage yeast, has a variety of constructor enzymes and other proteins that direct the assembly of the actual uracil molecule; then those constructor
enzymes or proteins’ genes are genetically modified so the constructor enzymes work a little differently, perhaps causing them to do different things like put an extra NH2 on the cyclic part of uracil, or perhaps put an -OH where a =O is on uracil.
Possibly wobble uracil does something with novel chemical structure, like putting a P phosphorus on the uracil, or possibly making a multicycle (<=><=>) molecule; so the wobble uracil makes any kind of uracil chemical variant that it actually does from
modifications to the genes at the uracil production enzymes, then noting the product developer already has a genetic system that produces it, those nmerous wobble-produced versions of uracil are measured as to their anticancer effects. Perhps the PO4 or
PNOH uracil is stable enough to be incorporated into nucelic acid replication structures at the oncocytes but is so novelly HOMO shaped as to halt cytoreproduction of oncocytes. a 1000 times 1000 grid of tissue culture of well tissue cytes and oncocytes
could test an actual million variants on the uracil molecule for anti-cancer effects at just one testing plate. It might be possible, and complementary to planned variations on consructor enzymes, to mutate several thousand versions of uracil
constructing enzymes on a plate, in place, and then test their output right on the same spot with autopipetted or possibly sliced cheese-overlay on a waffle maker, then clamped to make a whole bunch of array elements, each with its own blob of cheese, so
a clamped grid with a sheet of oncocyte tissue culture tissue clamped at it to make an array, could produce a million sample areas of tissue culture tissue at a 1000 times 1000 grid plate. So, clamping the tissue with the waffle maker, would place the
tissue above the microwell sample of bacteria with wobbly enzyme gene variations that produce a million different variations on the uracil molecule, the two of them combined test each uracil molecule variant with an oncocyte tissue culture mini-blob to
effect.
phenylalanine production at yeast, bacteria, or plants as source of the phenyl group to produce enjoyable phenyl<alkane>amines at with biological systems like plants, yeast and yogurt bacteria. Phenylethylamine is different than the chemical produced
but it is one of many stimulating, nootropic, near-euphoria producing chemicals that I perceive can be made, and have been published, that arise from a phenyl, and an amino group at the same molecule. This phenyl amino chemical makes people actually
like and enjoy the experience of the beverage, yogurt or plant. With an optimal phenyl<chemical>amine the experience could be much better than tea and a really beneficial experience that was physiologically harmless.
and uracil dimers that function a lot like fluorouracil but are particularly chep to make, wobble uracil might be easily and cheaply produced at yeast or bacteria or plants, that means than a cancer treating fermented beverage, yogurt, or vegetation
plant can be produced on demand, without central authority, and ultraffordably at the developing world.
rapamycin, the chemotherapeutic molecule, slightly modified to be a senolytically effective version of the rapamycin chemotherapy drug. That way if you get a false positive on a cancer test, and take senolytic-rapamycin for 10 weeks your lifespan and
healthspan go way up. based on the name -mycin it is possible rapamycin started out as a fungi product, if so, perhaps senolytic rapamycin could be engineered to be produced at yeast or bacteria so is available as decentralized, autorenewing longevity
and wellness senolytic drug that treats or cures cancer;
one of the things about the perfumed antibody pee test for cancer is that a math structure where if the detection rate finds one cancer in 10,000 concerned persons, and one false positive in 5,000 concerned persons, the likelihood that he cancer test
actually found cancer is only 1 in three; so the math of the part where treatment with a senolytic longevity and healthspan enhancing drug that also happens to be an anti-cancer chemotherapeutic drug causes decades of greater longevity and healthspan at
a well person and saves decades of living at each person when the drug effectively treats or cures the cancer; that makes treating a false positive, without using any followup tests or even medical practicioner visits, net beneficial to each individual,
and more net beneficial to the group as a whole. The nonoptimal part of course is that the person spends 10 weeks on rapamycin or dasimutib or someother chemotherapy drug, and likely feeling nonptimal while they are on it. So, at the developing world,
they could use senolytic anticancer drugs and skip actual visits to medical practicioners, further tests, imaging, and hospital stays; notably though, the cancer tests could only test for those cancers with a 90% pills-only cure rate. So if cancer were
detected with a 2.5 cent pee test, 9 out of 10 could be cured with just pills, and if the confirmationless test was a false positive the longevizing and healthspan of the senolytic anticancer drugs would cause net benefit to the treated person.
At the developing world, aligning promoted, automatic tests around things that have ultraffordable treatments could be a group longevity and wellness optimizing strategy; if social and fiscal resources could only cover a part of testing and treatment at
all the possible illnesses that might occur at the developing world.
dasimutib, molecularly modified to treat and cure the most curable cancers, that the perfumed antibody cancer tests looks for; dasimutib, or the actual name of the d-something-ib senolytic drug that is also a chemotherapy drug. It makes mice live longer
from the senolytic effect. Modifying name-like-dasimutib (tested with quercetain)(called DQ here) anticancer senolytic to be effective at treating breast cancer causes a numeric effect where DQ causes such a number of increased person-years of living
tamoxifen molecularly modified to be a longevity and healthspan increasing senolytic; notably wikipedia says tamoxifen is produced now with either yeast or bacteria at bioreactors, so a beverage yeast or yogurt bacteria source is a technology beneficial
at the developing world, decentralized and ultraffordable technology, that is apparently a slight modification of what already exists.
aminocurcurmin, curcurmin is like a 50% active senolytic at a graph I saw, so a modification to the curcurmin molecule could produce an anticancer chemotherapeutic drug. An ultraffordbale version produced at a plant or yeast might be possible as
curcurmin is already a plant product; as a plant product it is possible that even a modified curcurmin, like an aminocurcurmin, where the amino group placed on the curcurmin, or some peptide or protein on the curcurmin causes it to be actively
transported across the cytomembrane causing oncocytes to gather it.
perfumed antibodies increase sensitivity, resolution, and the number of chemicals that an immunochemical pee test can respond to
gel capsules are perhaps less than 1 cent, noting fiber optic magnifying a color, It seems possible that a particular shape of gel could magnify a 1mm sized immunodot, noting there are 21 of them at a three line imunnochemical pregnancy test to make them
5c and 1c gel magnifier
a new to me immunochemical diagnostic, like a dollar storepregnancy test, would be breathing out at a microstraw or regular sized straw so that moisture condenses, then having the immunochemical color shift chemical react to the exhaled condensate. I
have no idea what biochemicals concentrate at breath condensate, but they could make a list of all of them, and any that predicted or indicated wellness or illness could be the basis of useful antibody-color shift diagnostics. I perceive beverage
stirring microstraws might be less than 1 c each. the part where immunochemicals are printed, or rinsed through, the interior of the microstraw is one thing; It is possible that coating the microstraw (or full sized straw) with a deliquescent material
that liquefies when breath is breathed on it could make the immunochemical much more rapid to react, and able to react with less human moments spent blowing on the straw. Another possibility is that or, possibly NaPCA combined with a acylamide gel, to
make a fast inflating liquid gel reservoir with color change indicator at it, possibly making positioning of a “readout line” from a particular viewing angle, possibly near a part of the microstraw that had a lensish blob of plastic near the gel blob;
that way the more regular environment and structure of the NaPCA with polyacrilimide gel blob causes more predictable reactivity, and lens-located readability than colored NaPCA syrup would; also the gel blob technology could be near 1c as the amount of
immunochemical could be much less than the amount required to make an NaPCA syrup turn color enough to see. (although the microstraw might be another 1c) Also, with a condensate immunoscreening straw, the autohydrating gel blobs could be at a linear or
geometric array, and each blob at the arrary could report on the immunodetection of a different chemical. Although it could be possible to heap up or multiplex some immunodetected chemicals to provide benefit, for example, 10 immunochemical responses
that test fro cancer could all heap into one gel blob at a line or geometry of 7 or 20. If that one gel blob is nontransparent then perhaps there is a 1/3 or 2/3 chance the sample provider, who breathed into the straw
comparing immunoscreening the entire volume of a few liters of comparatively concentrated circulatory fluid with the few hundred ml of pee at a pee test, the number of different chemical-form or cytosurface things that can be antibody-glommed is
possibly tens of thousands of times to millions of times higher as to the number of available chemicals and outer cytostructure to a immonodiagnosis from, that means the diagnostic is much better at finding disease, or even finding wellness. Also, as
the perfumed antibodies release the perfume, which is another way of saying the chemically unique, high affinity, possibly linked to a molecule that the kidney preferentially excretes, reporter chemical (possibly a uniquely sequentially coded peptide or
biopolymer, the production of the peptide or biopolymer sequences could be automated so that they are automatically produced in peptide codes for digits 0 to 1 or 2,000) that is excreted at pee; Then when the person puts the
fizzy tic-tac or microcoated aspirin at 2 c to less than 1 c each. They turn blue to communicate that cancer chemicals were detected,notably at cancers that are very easy and affordable to cure.
Minimizing false positives at a cancer test: multiple simultaneous immunoactive diagnostic antibodies: find (immunodetect) say three chemicals, each a separate independent indicator of cancer, although the false positive might be 1 per 1000, three
chemicals have a combined preence false positive of 1 per billion. such as perfume from perfumed antibodies, but it could just be nonperfumed naturally occuring cancer predictive chemicals at pee. Also, although it seems possible to come up with a
different system, an immunochemical pee test, similar to a dollar store pregnancy test, could have histograms made from antibody-color bar segments. If the cancer bar was three rectangles high then it is the one false positive in a billion, three
antibody simultaneous response. If the cancer histogram bar is only one rectangle high it might just mean “think” or perhaps, “senolytics make you live longer and be weller, the cancer being tested for has a 95% cure rate from oral chemotherapy
alone, so you are in great shape if you just get the chemotherapy pills and take them” Then because the test makers and distributors have structured the antibody tests to find cancers that have high treatability, the person can have a medically
beneficial, senolytic, lifespan heightening cancer treatment that cures 95% of cancers of their tested type without further medical assistance, imaging, hospitalization or even physician contact. That makes cancer treatment, of cancers that can be
successfully be treated, much more affordable and also more widely treated at the developing world.
Depending on how you look at the numbers, an oral perfumed antibody pill could be as little as 5 C Online, one gram of various antibodies at bulk is $573, and imaginably, 100 nanograms could be a perfume antibody dose for glomming of just one chemical.
So that makes a 100 chemical diagnostic amplifying pill with 10 micrograms of antibodies, so at 100K doses per $573, the amount of C on the antibodies at each perfumed antibody pill is about one half cent per pill. Now the way the perfumed antibodies
are linked to ATP and have a numeric-like biopolymer antigen for the pee test to respond to goes with a 10 or 20 times higher C amount, so 5 to 10 c a pre-pee test pill that causes 1000 different body chemicals to be visible at a 5 C gel bead 1mm active
chemical pee test.
chronological interval of perfumed antibody delivery, ok, if you snort perfumed antibodies, they start circulating in 5-20 minutes, then possibly use another 20 minutes to glom onto some easy things at the circulation; If the perfumed antibodies perfume
part is attached to a molecule that the kidney preferentially excretes, then it is possible that diagnostic, detectable amounts of perfume accumulate at the bladder in 15-30 minutes. So 45-50 minutes after you snort it, a pee test diagnostic reads what
it says.
Comparing this to an oral perfumed antibody pill, an enteric coated pill, that fizzes automatically to dissolve at the part of the upper GI tract least destructive to antibodies; so it takes 4-6 hours before it fizzes and the perfumed antibodies can
commence a 4 hour absorption to the circulatory system period. At 4.5 hours the bladder concentration of perfume from the perfumed antibodies is high enough to diagnose with a pee test. So an oral version is 8-10 hours after dosing to getting a
diagnostic from the pee test.
Accumulation of perfume molecules at the bladder from attaching the perfume molecule to drugs that cause excretion of the chemical; (the perfume is after separating from the antibody that glommed a particular, protein, peptide, cytostructure, or chemical
at the body, notably all the capillary containing tissues as well as all the material at the circulatory system.
So, a perfumed antibody could possibly travel through a capillary, sometimes make its way to the cytes adjacent to the capillaries epithilial lining, and sometimes actually attach to the chemically unique antibody glommable outer surface chemistry of an
actual cancer cyte. Other times perfumed antibodies could just glom onto circulating biochemicals that are only produced at oncocytes, or possibly glom onto some protein or even leukocyte surface that goes with finding and glomming a systemic response
to oncocytes and oncostructures. These all utilize antibodies to find cancer, or find cancer is basent.
perfumed antibodies that leukocytes and macrophages eat: noting that the perfumed antibodies that get eaten, then possibly digested at the vacuole of a leukocyte or macrophage: The perfumed antibody could be constructed and engineered to have molecular
parts so durable they made it past vacuole digestion; the durable molecular parts being pooedout at the leukocytes or macrophages that leave durable molecular pieces that another different antibody is tuned to to cause a different perfumed antibody to
glom it, and send sufficient perfume to the pee to say “leukocytes at the body are eating things that TGW300 glommed onto. TGW300 attaches to: highly easy to cure cancer cyte surface protein. So if the other perfumed antibody that glommed the
biopolymer remains of the first immunochemical at the poo of the leukocyte or macrophage, is excreted at the bladder, then peeing on the test diganostic would say that leukocytes are meeting oncocytes at a person’s body.
Possibly strong popypeptides, or some other oligomer-like biopolymer like a custom-shaped starch (cyclodextrin or godel escher bach dextrin lumps that have high and unique antibody affinity), or the material degradable sutures are made from, or keratin.
perfumed antibodies at pee test during pregnancy describe fetal biochemistry from fetal metablic products that pass the placenta; paternity test while abortion pill still has weeks of available function and can abort if the pregnant person finds the
genetics, personality, or situation of the paternal gene source to be nonoptimal from the pregnant person’s perspective.
technology I do not know: a drug, that is actively beneficial to a fetus and possibly also the mother, possibly a snortable peptide or protein, that, like antabuse prevents drinking EtOH. People could take this to benefit their fetus and potential baby,
and as a side effect it would keep them from consuming EtOH, but I do not actually know how it works. some thing like antibodies to the actual eentsy molecule EtOH, that when they glom
perfumed antibody with fluorophores, three simultaneous antibody different chemical gloms, makes a 1 per thousand antibody glom false positive occurence go to a one per 100 million or 1 billion false positive occurrence if all three antibodies to
completely different chemicals are there simultaneously.
That multi-antibody response to build a diagnosis is beneficial as a fluorophore antibody diagnostic could test 1000 different chemicals at fluid from the circulatory system; fluorophore:ATP:antibody a fluorophore with an ATP linking it to the chemical
glomming antibody; when the antibody gloms, the ATP snaps off a PO4, and the fluorophore is then at the circulatory system, with part of an ATP such as an ADP or AMP attached to it, which makes it particularly distinguishable to the computer reading the
fluid sample at the test (noting there would be fluorophores attached to unglommed antibodies, and that telling the difference between these and reacted fluorophores antibodies produces daignostic data at the test)
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All technologies, ideas, and inventions of Treon Sebastian Verdery are public domain at JUly 8,2023AD and previously, as well as after that date
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