Rescuing children
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All on Sat Oct 8 20:20:22 2022
Medicines that are effective and highly affordable benefit children, globally and at the developing world;
I think peptide drugs are often dosable at near 100 micrograms to 1 milligram each, a million milligrams at $1000 is 1/1000 of 1 cent a miiligram dose, it is 1/100th of a cent, at 100 micrograms per dose it is 1/10,000 of 1 cent ($1000 Kg) , 100
micrograms at $10,000 a Kg is 1/1000 of 1 cent, screening the database of about 40 million (2019)
Pubmed/PMC articles to find the 300 peptides most likely to succeed as drugs comes from parsing the data
One approach to parsing the data is a computer program, a database, or an AI, possibly a deep learning AI
Find peptide name
Find math 40 reporting types
Rank math number reports
Finding peptides previously used as drugs:
Alternate version, crowdsourced human screening of 10,000 to 100,000 most likely pub med PMC records the computer finds
Automated software finds patient studies and nonhuman mammal srudies
40 words like "response", " administer",
Research source: medical center
Find patient words
Stand alone sentence like "antibiotic peptide reduces days of unwellness"
Screen again as complementary therapy, " fluorcorticoid adminstered with GABA peptide"even though drug drug interactions
find the simultaneous occurrence of the worlds 100 most common diseases and also the statistical math expressions of high. effectiveness at at pcausing any change at the hypothesis,
at jnoting that Pubmed/PMC says it indexes about 40 million papers during 2019 AD, parsing the data to gather peptide name, amount of from automatic parsing, and having the software find the peptides with the highest p value are simultaneously published
as having possible medical application among all medically active peptides, and software that parses of the active peptides, or, variously listing the three most likely to be medically useful at the 100 most frequently occurring illnesses is another
way to generate a list of 300 medical drug peptides;
The list of the 300 most immediately utilizable peptide drugs could be refashion as medicines; oral vasopressin utilizes a combination of chiral amino acids to omit digestion from GI tract enzymes, it is possible peptide sequencers and comparatively
uncomplex software that generates 10 million variations in software then makes a list of 1 million that the least projected enzymatic digestion at the GI tract, then a peptide sequencer attached to a million channel microfluidic chip I read about could
move the million peptides have enzymatic digestion blocking chirality exposed lysine amino acids; I do not know how meaningful enzymatic lysine cleavage is but I think I read it is a frequent enzymatic cleaveage site; people that know whether it is
better to make 500,000 peptide variants of GI tract enzyme and pH undigested, structurally projected at software as passing membranes and reaching the circulation, peptides then screening them on yeast or human tissue culture at a one million well plate
is more sensible than having 11 technologists use software and CAD to just draw the structures they think will pass the GI tract, notably the orally dosed vasopressin peptide that passes the GI tract to be absorbed, based partly on having two
chiralities of amino acids rather than just the one chirality that the digestive tract enzymes cleave (digest) peptides with, then the technologists could use CAD and a programming language to automatically replace some of the peptides at the structure
library with chirally unusual nucleotides, then automatically modify the structure library to put something like an intestinal membrane transport peptide, possibly cleabeable at the circulatory system with a circulatory system circulating enzyme that
cleaves away the transport nucleotide sequence; i think i read that at least one enzyme cleaves peptides on the amino lysine, the technologist might use CAD to swap lysine with another. Most similar amino acid to preprocess the 300 medical peptides
before the 11 technologists customize the CAD specifications of the 300 medical peptides, perhaps making 20 version variations for a higher functionality screenable library of 6000 peptides, there is a possibility (?) That the 6000 medical peptides could
then be transported through a microfluidic reactor with sequential digestive enzymes and pH areas to find out which peptide versions of the 300 medical peptides among 6000 will reach the circulation with fulldrug function; the peptides that pass the
microfluidic reactor can then be automatically transported to a 10,000 well plate yeast culture matrix or also human tissue culture to find each version of the 300 medical peptides
If the parallism of the microfluidic enzyme system and the quantification of drug activity at the 10,000 well plate supports it then greater than 300 medical peptides can be made to become orally available drugs;
GSK
from staying awake for 48 hours a few days a week I got mild dermatitis, when I was under 18 I had atopic dermatitis, I noticed then that it was really distracting, to put it diffidently, the distracting part of the symptoms of dermatis nearly completely
cease when i take about 2.5 grams of phenibut. And the anti itch cool, original color skin lasts 16 hours;
An oral anaesthetic that localizes at the dermis or sCNS blocking of nerve communication? skin heals more rapidly when I take phenibut suggesting dermis neuron or other effects; that's wonderful because some kind of molecular activity amplifier like
halogen (perhaps gabapentin which is a lot like chlorophenibut) or some new to me thing would be functional;
Orally dosed body side phenibut, that is a phenibut variant that stays on the body side of the blood brain barrier, could heal dermis while removing almost all symptoms, also dermatitis rash cools and dermis turns to the well white Caucasian color of
the areas without dermatitis after a few hours to 24 hours, so if a modified phenibut molecule, perhaps with 400 amu moiety on it that keeps it from passing the blood brain barrier cools, and removes the dermatitis rash visual effect as well as causes
actual healing with skin softening as rapidly as 24-48 hours without washing or being clean when dirty, then that body side version of phenibut could also be absent what I read about phenibut at the CNS; if you take it frequently like 7 days a week your
CNS GABA receptors will deregulate and your undrugged mood might be more restless, kind of like an adaption to sedation even though phenibut is a nootropic, so it is possible body side only phenibut could be utilized 7 days a week without deregulating a
person's CNS and effecting their mind; so body side only variation on the phenibut molecule
Also phenibut could make peripheral nervous system side reflex better (nootropic), or slower (GABA sedative, just at the peripheral nervous system;
noting 7 days a week of phenibut for a month could deregulate gaba receptors and CNS based emotions, would quitting body side phenibut cause a "rebound rash", at least that is easy to test with just a few N to get a p value; noting continuous multiday
dosing a GABA active drug causes receptor change of some kind at the CNS, if there is rebound rash at dermis, even with a bodyside molecular variant that does not reach the CNS, then screening a library of phenibut molecules is possibly a thing where
noting without an absence of "rebound rash" it is not functional, if a new phenibut atopic dermatitis molecule is reboundrasless and functional it becomes a highly wonderful one pill a day atopic dermatis symptom removing pill that also causes healing
even without washing, something that when i had atopic deratitis when i was less than 18 bothered me and sometimes washing seemed to make the atopic dermatitis even less pleasant; screening a library of a few hundred, or a million wells at a dermal
tissue culture plate could find a phenibut variant of greater effectiveness per mg; note I do not know if "rebound rash" actually exists
Dermal localization, 1/40th the dosage; oral phenibut is 2.5 grams for a dose, localizing forms of the molecule could make the oral dose 63 mg, which is beneficial as 2.5g is a few big pills, or alternately, like phenibut, a take with water drug and it
tastes crummy;
Is a body side dermal soothing and healing effect from GABA, or is it some other chemical effect, if it is some other effect then screening a library of orally active phenibut molecule variations that are nongaba active therefore also completely
different than gaba active phenibut molecular variants would be beneficial. Radiolabelling phenibut would also locate the nonGABA receptors at the skin that phenibut might be reaching, this could be quantified as to how much of the radio labelled
phenibut is reaching what parts of the dermis and they could make a localizing version that just went to the preferred area of the dermis, optimally just the layers of the dermis where it soothes itching, and the layer where oral phenibut makes healing
even more rapid than a person that has not bathed in 22 days washing;
Halogened glucocorticoids are a 2019 dermatitis medication, it is possible that attaching just the part of the phenibut molecule to the halogenated glucocorticoid would make a new screenable library to find a beneficial atopic dermatitis treatment;
So I read some children got atopic dermatitis during 2019, this technology benefits them;
Also halogenated glucocorticoid ointment itches, if phenibut also functions topically this could be an itchless a topic dermatitis treatment
Rescuing children, it is possible that some toys and adult-effecting prompts and reminders decrease the number of what are published as adverse childhood events, I perceive I read more than two of these events is linked to non optimal child and matured
child existence; toys that cause child-parent as well as child-adult (resident boyfriends) cooperation could be quantified, identified and created, also it is possible some toys cause voluntary pleasant earnest child initiated conversation that is absent
causing nonfunctional adult behaviors; one approach is a standard globally available application that video and audio records actual families with verified previous adverse child event occurrences and find out what prompts adult nonfunctional behaviors
as well as preferred beneficial adult behaviors, notably this software can figure out when things are going various ways, Building cameras and software that alerts people to atypical or trouble correlated behaviors, reducing staff amounts and preventing
trouble, what i perceive as like-it-ometers at company based 20th century advertising research which as of 2019 AD has likely gotten much more effective at interpreting attention, storing, and interactively prompting; then the application as well as the
computer mediated speaker (like cortana child advisor or amazon echo), the media center, or personal computer then provides Actual lists of toys, activities and conversation topics that find a few hundred or thousands of things Amazon.com 90th percentile
of review liking at the things the voluntary family communications and behavior guiding application software notes that at that family, as well as psychometrically similar families is beneficial and precludes things detrimental to human physiological
children; these prompts and activities, and topic of conversation and actual action guides are at the 94th percentile or greater of always going well, at that child and adults psychometrically estimated (video and audio) personality form; Then with that
anonymized data create voluntary toys, routines, and electronic or media content where these are more enjoyable to both adults and children than previous toys and routines and media; this prompted utilization of optimal toys, topics, behavior and media,
being more enjoyable, also behavioral psychology reward as well as possibly, amongst some families, although not all, more convenient, it is possible that giving the child a child preferred enjoyable hug, even from resident boyfriends, causes more
beneficial treatment of children; this effect could be non conscious or conscious; motivational posters,
As previous described cortana child advisor, amazon echo computerized speaker prompted live responsive content that guides adult child interaction towards the 94th percentile of awesome wonderful and optimal;
Advertising replacements, online these might occasionally be clicked and beneficial adult-child behaviors are taught,
90th percentile of beneficial child adult interactions could be taught, like communicating to an insistent (very possibly valid insistence) child "you can have any three things you would like, then the adult makes suggestions), then talk about the
different utilities (sleepover with like messaging or phoning their friend) who is like a version of noted thinker and creator JoAnn von Neumann, (14 hours of awesome friendship, although some of it is asleep), anything you like at the evening meal (
about 40 minutes of what the child likes), or even scheduling one of the 7 " I just feel like it" annual days off school, (about 6-7 hours of better, depending on how much the child likes school as compared with riding their bike around at 11, or also
being at the dwelling without anyone around), reading a story together, or perhaps something new called attention deluxe, basically highly responsive, slightly "awaken the giant within" (Tony R) and "how to win friends and influence people", quality time,
likely right away; this is a way of causing 90th percentile of child and adult benefitting action; if the three things all defer action then simultaneously the child practices planning and looking forward to something as well as big five psychology
test conscientiousness, as well as thinking about different values, all this, while, depending on the things the adult suggests, the adult has deferred changing the course of their evening (the adults existence remains easier), and noting the adult loves
their child suggesting and doing things that simultaneously make their child happy the longest interval, a thing that the child gets to think about, while providing growthful, possibly educational, Ability practicing, or social skill amplifying
enrichment is beneficial; what if though, they really want to play now;
The application software could also utilize software models as well as fresh anonymized data about the way particularly happy successful children are raised, and have software application options that let
Rescuing children, it is possible that some toys and adult-effecting prompts and reminders decrease the number of what are published as adverse childhood events, I perceive I read more than two of these events is linked to non optimal child and matured
child existence; toys that cause child-parent as well as child-adult (resident boyfriends) cooperation could be quantified, identified and created, also it is possible some toys cause voluntary pleasant earnest child initiated conversation that is absent
causing nonfunctional adult behaviors; one approach is a standard globally available application that video and audio records actual families with verified previous adverse child event occurrences and find out what prompts adult nonfunctional behaviors
as well as preferred beneficial adult behaviors, notably this software can figure out when things are going various ways, Building cameras and software that alerts people to atypical or trouble correlated behaviors, reducing staff amounts and preventing
trouble, what i perceive as like-it-ometers at company based 20th century advertising research which as of 2019 AD has likely gotten much more effective at interpreting attention, storing, and interactively prompting; then the application as well as the
computer mediated speaker (like cortana child advisor or amazon echo), the media center, or personal computer then provides Actual lists of toys, activities and conversation topics that find a few hundred or thousands of things Amazon.com 90th percentile
of review liking at the things the voluntary family communications and behavior guiding application software notes that at that family, as well as psychometrically similar families is beneficial and precludes things detrimental to human physiological
children; these prompts and activities, and topic of conversation and actual action guides are at the 94th percentile or greater of always going well, at that child and adults psychometrically estimated (video and audio) personality form; Then with that
anonymized data create voluntary toys, routines, and electronic or media content where these are more enjoyable to both adults and children than previous toys and routines and media; this prompted utilization of optimal toys, topics, behavior and media,
being more enjoyable, also behavioral psychology reward as well as possibly, amongst some families, although not all, more convenient, it is possible that giving the child a child preferred enjoyable hug, even from resident boyfriends, causes more
beneficial treatment of children; this effect could be non conscious or conscious; motivational posters,
As previous described cortana child advisor, amazon echo computerized speaker prompted live responsive content that guides adult child interaction towards the 94th percentile of awesome wonderful and optimal;
Advertising replacements, online these might occasionally be clicked and beneficial adult-child behaviors are taught,
90th percentile of beneficial child adult interactions could be taught, like communicating to an insistent (very possibly valid insistence) child "you can have any three things you would like, then the adult makes suggestions), then talk about the
different utilities (sleepover with like messaging or phoning their friend) who is like a version of noted thinker and creator JoAnn von Neumann, (14 hours of awesome friendship, although some of it is asleep), anything you like at the evening meal (
about 40 minutes of what the child likes), or even scheduling one of the 7 " I just feel like it" annual days off school, (about 6-7 hours of better, depending on how much the child likes school as compared with riding their bike around at 11, or also
being at the dwelling without anyone around), reading a story together, or perhaps something new called attention deluxe, basically highly responsive, slightly "awaken the giant within" (Tony R) and "how to win friends and influence people", quality time,
likely right away; this is a way of causing 90th percentile of child and adult benefitting action; if the three things all defer action then simultaneously the child practices planning and looking forward to something as well as big five psychology
test conscientiousness, as well as thinking about different values, all this, while, depending on the things the adult suggests, the adult has deferred changing the course of their evening (the adults existence remains easier), and noting the adult loves
their child suggesting and doing things that simultaneously make their child happy the longest interval, a thing that the child gets to think about, while providing growthful, possibly educational, Ability practicing, or social skill amplifying
enrichment is beneficial; what if though, they really want to play now;
The application software could also utilize software models as well as fresh anonymized data about the way particularly happy successful children are raised, and have software application options that let
The child-parent or also child-adult (like the parent's resident girlfriends boyfriends) video audio software application at the dwelling that the adult(s) voluntarily utilize to minimize any deleterious adult behaviors or actions effecting the child,
mild things as well as the 2019 AD published research I saw a simplification of, about adverse childhood events, two or more of which were linked, at genetically unenhanced, as compared with the heightened intelligence, greater beauty than any person
that previously ever lived kind of beauty that causes more beneficial treatment, as well as 99.99999th percentile (2019 AD personality distribution) of kindness, children's resilience, socially capability and fluency, as well as the similarly beneficial
characteristics with greater beneficialness at and among genetically optimized children, noting that among 2019 AD genetically unenhanced and unoptimized (as well as, noting the genetic modification of other organisms the option of getting genetically
enhanced phenotypic form, and at the person, that is human' that is member of a group of people' that is homo sapiens' voluntary preference, genetic optimization therapy), the benefit of adults favoring children so much that the adults are kind,
beneficial, nurturant, prompting of beneficial growth, prompting of beneficial heightened capability, as well as physically and emotionally gentle, providers of sustenance as well as a dwelling
At cytes, possibly mycoplasms or other living cyte organisms 1/24 the diameter of the cyte-residing 2019 computer generated genome mycoplasm constructed earlier than 2019 AD and described at wikipedia, at a form that is capable of doing computation and
has somatic intracyte communication as well as communication with the entire voluntary host organism (such as a human, a person, a member of a group of people, a homo sapiens) somatic form with the form and chemistry as well as electric and molecular
electron density mappable form, modified with gene therapy as well as, optionally, endocyte data communication, is capable of making an adjacent stem cyte with a fresh optimized genome with all the multidirection exterior cytomembrane chemical flows,
mappable electron field density and amount, as well as receptor quantity, size, and locationality of the cyte it is next to while having a fresh genome, it is capable of modifying chemical flows, surface receptors as well as electrical characteristics at
the amount the computing endocyte as well as the fresh DNA of the optimized genome direct; modifying all the cytes, tissues, as well as atoms that compose the cytes and tissues at between the less than 14 hours to duplicate the entire human's, that is
persons, that is members of a group of people, that is homo sapiens' cytoform, when reutilizing atoms, a 40 times more gradual doubling than the 20 minutes to double bacteria cytoforms and the 16.9 pound gestational 24 hour mass gain of a fetal whale,
the genetic as well as somatic optimization of a human, that is a person, that is a member of a group of people, a homo sapiens utilizes between less than 7 hours to less than 270 hours to accomplish a full body replacement
Scientific American says IQ predicts longevity although I perceive it also says rapidness of response of pressing a button has better longevity predicting effect; that suggests screening molecular variants of nootropics as well as stimulants could find
new longevity heightening drugs and chemicals; longevizing nootropics as well as stimulants could function at different parts of a neuron; dendrites, synapses, myelin, like myelin sheaths, axons, as well as the large volume central area, also things
transported to the cytoplasm, possibly aquapeorin could differ from receptor effects, I am not aware of any stimulant membrane lipids, there are nootropic lipids like phosphatidyl serine, all of these could have molecular variant libraries produced and
then screened at c elegans, drosophila, 96 well plate fish, age batched mice, age batched marmosets, as well as age batched voluntarily human experimental participants
Wikipedia says delta Fosb is linked to deleterious effects of some 2019 stimulants, a yeast or fish screen for fosb to find stimulants that do not cause fosb effects could decrease risk; during 2019 a number of stimulants were deleterious and it is
beneficial to make stimulants that have only beneficial effects;
Another approach to longevity genetics is to breed c elegans with twice as many neurons and twice the neural velocity response to beneficial stimuli and twice the memory capacity then measure any increases in longevity then trace them to genetics;
I had thought that putting mouse cytes in rats would cause an immune response, I read that mouse neurons transplanted into rats lived longer than at mice, it is possible the longevizing effects of connecting two rodent circulatory systems (younger and
older) could be accomplished with rats and mice to find out if young rat circulatory fluid heightens the maximum lifespan of mice; if it does then rodents could be screened to find those with an order of magnitude greater longevity as well as an absence
of immune response, mice and beavers, noting beavers live about 14 times longer than mice, if there are multidigit % gains then the beaver or other rodent circulary fluid could be characterized as to the lomgevity chemicals or cytotypes that cause the
greater longevity, these could then be administered to age batched marmosets to find out if they heighten primate longevity; then at voluntary human experiments at age batched humans those chemicals could be administered to find out if they heighten
human longevity;
Longevity technology:
Reaching as many people as possible with longevity technology is beneficial; it is possible that having mice do the 24 most physiologically deleterious things that humans do and simultaneously orally dosing them with longevity drugs (2019 rapamycin and
rapalogs, Epithalon AEDG peptide, metformin, others) could find longevity drugs that cause any humans with deleterious behaviors or habits to outlive unmedicated humans, this is possible during 2019 AD and could cause humans to seek out longevity drugs;
Make a list of longevity drugs for Shay Stacer
A longevity drug compatible with the most prevalent distribution channels is beneficial; groceries are among the frequently visited locations, milk, peanut butter, near instant carbohydrate products, as well as the eggs of genetically modified chickens
as well as other products could be longevity drug enhanced grocery products, items near the register the acquisition of which is often unplanned, like candy bars as well as 2-4 ounce energy drinks, are also often near the register; one or more doses a
month increases longevity; metformin, made flavorless with microencapsulation, as well as 10HDA (10 H2DA), also enteric and liposomal Epithalon (AEDG) peptide, as well as palmitate versions, enteric coated flavoredless reishi active chemical component as
well as the other chemicals could be physiologically compatible with human physiological children. It is valuable to have grocery foods be compatible with human physiological children.
Reishi is published as heightening yeast longevity, longevity heightening rf-3 may a longevity chemical, there are a numerous ganoderma species, it is of value to quantify the longevity effects of reishi as well as other ganoderma species at age batched
mice preparatory to making them a high distribution grocery available food ingredient
Eggs with reishii longevity heightening active chemicals as well as Epithalon, possibly combined with thymosin peptide (four times more likely to be alive after 6 years) could be be an ingredient component or produced at genetically engineered chickens
as well as milk cows, or other milk producing mammals
Immune system activity may or may not be associated with heightened longevity; immunizations like possibly BCG or others could cause 14 year old like immune system profile at persons of other ages
At some organisms the form of sugar they eat heightens longevity, midges fed honeydew have greater longevity than midges fed other sugars, the effect of honeydew equivalent on mouse longevity, if any, could be quantified, if there is an effect then
honeydew equivalent sweeteners could be made a part of human food; candy, candy bars, supplemental sweetener at a variety of grocery foods
Immunizing against galactose could heighten healthspan and preclude some illnesses heightening longevity
Epithalon, AEDG peptide linked to stomach passing peptides like a mostly nonactive form of the oral version of vasopressin could be a longevizing sweetener at foods, although vasopressin is a nootropic I perceive it is active at microgram amounts while
Epithalon is active at milligram amounts , although I perceive I read Epithalon is also active at micrograms or eentsier dosage, that suggests linking Epithalon with a high pH degradable linker molecule or peptide or protein as well as using a stomach
passing nonactive orally available vasopressin related peptide could be of value; similarly a thymosin Epithalon peptide coingredient could be quantified as to healthspan, wellness and greater lifespan
An oil replacement at foods could possibly be a vinyl ether phosphatidyl serine polymer, olestra is a sugar polymer and is utilized as an oil replacement at foods; naked mole rats have greater longevity than mice and have the vinyl ether version of
phosphatidyl serine
It has value if they can quantify heightened longevity effects although is is actually unlikely to function: they could screen a million variations on sweetness peptides on yeast, then if the 99.99th percentile of longevity heightening is actually
longevizing they could parallel test 100 sweetness peptides at mice to find out which ones have preferred flavor, a volunteer experimental participant human could then taste the 24 most preferred longevity sweeteners at milk and the more delicious
variations could be quantified at mice as to mammal longevity effects; if there are longevity effects the longevizing sweetness peptide could be attached to a stomach passing orally available peptide like a vasopressin modified to be physiologically
nonactive with a high pH degradable linker to be a part of human food
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