• Gene loss

    From RonO@21:1/5 to All on Tue Aug 8 05:57:27 2023
    https://www.biorxiv.org/content/10.1101/2022.12.09.519446v2

    Science news article: https://www.science.org/content/article/how-anteaters-lost-their-teeth

    Armadillos, sloths. and anteaters are related and have issues with their
    teeth. It looks like the lifestyle of the ancestor of the three is
    responsible for the degeneration of their teeth. Armadillos may have
    separated from the sloth-anteater branch before they started losing
    their teeth. It turns out that the two lineages lost their tooth genes
    in a different order. The common ancestor of sloths and anteaters lost
    several enamel genes before sloths diverged from anteaters. Anteaters
    went on to lose several more genes for teeth and became toothless, but
    sloths changed their diet and had to compensate for the loss of enamel
    by having their teeth keep growing. The armadillo lineage shows a
    different order of gene loss.

    This paper used psuedogene sequences for the analysis. In this case
    these pseudogenes are the gene "fossils" left in the genome when
    inactivating mutations occur in a gene and knock it out. The gene
    sequences is still recognizable but now subsequent mutations can freely
    occur in what is left of the gene because the gene is already nonfunctional.

    Ron Okimoto

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From *Hemidactylus*@21:1/5 to RonO on Tue Aug 8 12:22:30 2023
    RonO <rokimoto@cox.net> wrote:
    https://www.biorxiv.org/content/10.1101/2022.12.09.519446v2

    Science news article: https://www.science.org/content/article/how-anteaters-lost-their-teeth

    Armadillos, sloths. and anteaters are related and have issues with their teeth. It looks like the lifestyle of the ancestor of the three is responsible for the degeneration of their teeth. Armadillos may have separated from the sloth-anteater branch before they started losing
    their teeth. It turns out that the two lineages lost their tooth genes
    in a different order. The common ancestor of sloths and anteaters lost several enamel genes before sloths diverged from anteaters. Anteaters
    went on to lose several more genes for teeth and became toothless, but
    sloths changed their diet and had to compensate for the loss of enamel
    by having their teeth keep growing. The armadillo lineage shows a
    different order of gene loss.

    This paper used psuedogene sequences for the analysis. In this case
    these pseudogenes are the gene "fossils" left in the genome when
    inactivating mutations occur in a gene and knock it out. The gene
    sequences is still recognizable but now subsequent mutations can freely
    occur in what is left of the gene because the gene is already nonfunctional.

    Thank you for posting this Ron.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Bob Casanova@21:1/5 to All on Tue Aug 8 09:03:05 2023
    On Tue, 08 Aug 2023 12:22:30 +0000, the following appeared
    in talk.origins, posted by *Hemidactylus*
    <ecphoric@allspamis.invalid>:

    RonO <rokimoto@cox.net> wrote:
    https://www.biorxiv.org/content/10.1101/2022.12.09.519446v2

    Science news article:
    https://www.science.org/content/article/how-anteaters-lost-their-teeth

    Armadillos, sloths. and anteaters are related and have issues with their
    teeth. It looks like the lifestyle of the ancestor of the three is
    responsible for the degeneration of their teeth. Armadillos may have
    separated from the sloth-anteater branch before they started losing
    their teeth. It turns out that the two lineages lost their tooth genes
    in a different order. The common ancestor of sloths and anteaters lost
    several enamel genes before sloths diverged from anteaters. Anteaters
    went on to lose several more genes for teeth and became toothless, but
    sloths changed their diet and had to compensate for the loss of enamel
    by having their teeth keep growing. The armadillo lineage shows a
    different order of gene loss.

    This paper used psuedogene sequences for the analysis. In this case
    these pseudogenes are the gene "fossils" left in the genome when
    inactivating mutations occur in a gene and knock it out. The gene
    sequences is still recognizable but now subsequent mutations can freely
    occur in what is left of the gene because the gene is already nonfunctional. >>
    Thank you for posting this Ron.

    Ditto. Jus a comment, though: This sounds to me like the
    classic detrimental mutation, and it's remarkable to me that
    the species survived it; teeth are pretty significant, and
    barring the development of a replacement, such as a bill,
    would seem to be fairly necessary for species survival.

    --

    Bob C.

    "The most exciting phrase to hear in science,
    the one that heralds new discoveries, is not
    'Eureka!' but 'That's funny...'"

    - Isaac Asimov

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From RonO@21:1/5 to Bob Casanova on Tue Aug 8 17:03:12 2023
    On 8/8/2023 11:03 AM, Bob Casanova wrote:
    On Tue, 08 Aug 2023 12:22:30 +0000, the following appeared
    in talk.origins, posted by *Hemidactylus*
    <ecphoric@allspamis.invalid>:

    RonO <rokimoto@cox.net> wrote:
    https://www.biorxiv.org/content/10.1101/2022.12.09.519446v2

    Science news article:
    https://www.science.org/content/article/how-anteaters-lost-their-teeth

    Armadillos, sloths. and anteaters are related and have issues with their >>> teeth. It looks like the lifestyle of the ancestor of the three is
    responsible for the degeneration of their teeth. Armadillos may have
    separated from the sloth-anteater branch before they started losing
    their teeth. It turns out that the two lineages lost their tooth genes
    in a different order. The common ancestor of sloths and anteaters lost
    several enamel genes before sloths diverged from anteaters. Anteaters
    went on to lose several more genes for teeth and became toothless, but
    sloths changed their diet and had to compensate for the loss of enamel
    by having their teeth keep growing. The armadillo lineage shows a
    different order of gene loss.

    This paper used psuedogene sequences for the analysis. In this case
    these pseudogenes are the gene "fossils" left in the genome when
    inactivating mutations occur in a gene and knock it out. The gene
    sequences is still recognizable but now subsequent mutations can freely
    occur in what is left of the gene because the gene is already nonfunctional.

    Thank you for posting this Ron.

    Ditto. Jus a comment, though: This sounds to me like the
    classic detrimental mutation, and it's remarkable to me that
    the species survived it; teeth are pretty significant, and
    barring the development of a replacement, such as a bill,
    would seem to be fairly necessary for species survival.


    They think that the ancestor of armadillos, sloths and anteaters ate
    worms and insects, so they didn't need teeth. The armadillo lineage and
    the sloth-anteater lineage continued to eat bugs and worms and their
    teeth started to degenerate for lack of selection to maintain them. The
    sloth lineage changed it's diet, but was stuck with the degenerate
    teeth, so it evolved teeth without enamel that just kept growing so they
    didn't have to worry about wearing them out. Anteaters lost even more
    toothy genes and became toothless.

    Ron Okimoto

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Bob Casanova@21:1/5 to All on Tue Aug 8 22:19:08 2023
    On Tue, 8 Aug 2023 17:03:12 -0500, the following appeared in
    talk.origins, posted by RonO <rokimoto@cox.net>:

    On 8/8/2023 11:03 AM, Bob Casanova wrote:
    On Tue, 08 Aug 2023 12:22:30 +0000, the following appeared
    in talk.origins, posted by *Hemidactylus*
    <ecphoric@allspamis.invalid>:

    RonO <rokimoto@cox.net> wrote:
    https://www.biorxiv.org/content/10.1101/2022.12.09.519446v2

    Science news article:
    https://www.science.org/content/article/how-anteaters-lost-their-teeth >>>>
    Armadillos, sloths. and anteaters are related and have issues with their >>>> teeth. It looks like the lifestyle of the ancestor of the three is
    responsible for the degeneration of their teeth. Armadillos may have
    separated from the sloth-anteater branch before they started losing
    their teeth. It turns out that the two lineages lost their tooth genes >>>> in a different order. The common ancestor of sloths and anteaters lost >>>> several enamel genes before sloths diverged from anteaters. Anteaters >>>> went on to lose several more genes for teeth and became toothless, but >>>> sloths changed their diet and had to compensate for the loss of enamel >>>> by having their teeth keep growing. The armadillo lineage shows a
    different order of gene loss.

    This paper used psuedogene sequences for the analysis. In this case
    these pseudogenes are the gene "fossils" left in the genome when
    inactivating mutations occur in a gene and knock it out. The gene
    sequences is still recognizable but now subsequent mutations can freely >>>> occur in what is left of the gene because the gene is already nonfunctional.

    Thank you for posting this Ron.

    Ditto. Jus a comment, though: This sounds to me like the
    classic detrimental mutation, and it's remarkable to me that
    the species survived it; teeth are pretty significant, and
    barring the development of a replacement, such as a bill,
    would seem to be fairly necessary for species survival.


    They think that the ancestor of armadillos, sloths and anteaters ate
    worms and insects, so they didn't need teeth. The armadillo lineage and
    the sloth-anteater lineage continued to eat bugs and worms and their
    teeth started to degenerate for lack of selection to maintain them. The >sloth lineage changed it's diet, but was stuck with the degenerate
    teeth, so it evolved teeth without enamel that just kept growing so they >didn't have to worry about wearing them out. Anteaters lost even more
    toothy genes and became toothless.

    OK, that makes sense. Thanks!

    --

    Bob C.

    "The most exciting phrase to hear in science,
    the one that heralds new discoveries, is not
    'Eureka!' but 'That's funny...'"

    - Isaac Asimov

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)