• Re: Wistar Symposium "Mathematical Challenge to Neo-Darwinism".

    From Ernest Major@21:1/5 to Ron Dean on Fri May 31 20:00:00 2024
    On 31/05/2024 18:36, Ron Dean wrote:

    How the biologist responded to these "problems"? I've found nothing on
    the net. I found a book on Amazon for $300, but I'm not buying it. This symposium took place in 1966, so it's possible that the
    challenges have been met in the intervening years since then.

    At 10% of that price there is https://www.amazon.co.uk/Failures-Mathematical-Anti-Evolutionism-Jason-Rosenhouse/dp/1108820441

    The summary for chapter 4 is "We discuss the famous Wistar conference
    from 1966, in which high-level mathematical challenges to evolutionary
    theory were presented. We refute these challenges and discuss the
    historical significance of the conference in shaping modern mathematical anti-evolutionism."

    However, I
    know of several challenges that so far as I know have not been answered.
    The questions  are: There are over 500 amino acids found in nature, 50% left-handed, but if blind, aimless, unguided natural processes selected
    the 20 or 22 amino acids that used by all life what are
    the chances of these particular particular 20 left-handed amino acids
    being selected?  I realize there are theories offered to explain why
    only left-handed amino acids were selected, but what about the 20? Or is
    it possible that any other set of amino acids would have worked just as
    well?

    The last time you made this claim I tracked down the source of the 500
    number, and found that this was 500 different amino acids which occur in
    living organisms. I asked you to consider how many of these amino acids
    existed in meaningful quantities (if at all) on the pre-biotic earth. I
    presume that you haven't done so.

    I've also brought to you attention that 20/22 amino acids used by all
    life is an oversimplification. All variants of the genetic code encode
    20 proteinogenic amino acids, so those are used by all life. Some
    prokaryotes have genetic codes that also encode a 21st amino acid, i.e. pyrolysine. Wikipedia reports that the current consensus is that this originated in stem-archaeans, and has subsequently been horizontally transferred into some bacterial groups. A 22nd amino acid,
    selenocysteine, is also incorporated into proteins from the genetic code
    using a kludge. This is also not present in all organisms.

    However other amino acids are incorporated in proteins by
    post-translation modifications. I've previously brought to your
    attention that there's more hydroxyproline in human proteins than
    several canonical amino acids.

    Other amino acids play a role in biochemical metabolism.

    They you get into the weeds with amino acids such as canavanine (one of
    your 500). This is produced by some leguminous plants as an
    anti-herbivore toxin. It mimics arginine (a proteinogenic amino acid),
    from which it differs from by replacing a methylene bridge by an oxygen
    atom, resulting in it being incorporated into the herbivore's proteins
    to the detriment to their function. Specialist herbivores get round this
    either by having means of metabolising the canavanine before it gets
    near their protein synthesis machinery, or by improving the
    discrimination of their tRNA-arginine synthetases.

    There's a widespread belief that proteins are a relatively late addition
    to the biochemical repertoires, catalysis having been previous performed
    using RNAzymes. (RNAzymes are still essential for life.) If this is
    correct that would mean that amino acids and proteins can be added to
    the biochemical repertoires in gradual steps.

    People have studied the development of the genetic code, and inferred
    that the original code included fewer amino acids - perhaps as few as
    for. The addition of amino acids to the code would depend on
    availability and utility. The availability constraint biases the genetic
    code to simpler amino acids. The utility constraint biases the addition
    of amino acids to the code to amino acids which expand the functional
    range of proteins, i.e. which have properties (polar vs non-polar, basic
    vs acidic, hydrophobic via hydrophilic, etc.) not already found in the
    prior set.

    People have studied the robustness of the genetic code. The genetic code
    is not optimal for robustness against mutation, but is a lot better than
    a random one. Something similar may hold for the set of proteinogenic
    amino acids. Other sets might work perfectly well, but a set with, for
    example, only hydrophilic amino acids strikes me as likely to be
    relatively ineffective, or perhaps even not effective at all.

    --
    alias Ernest Major

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From El Kabong@21:1/5 to Ron Dean on Sat Jun 1 17:56:11 2024
    Ron Dean wrote:

    We've discussed this before. I think originally the genetic code was
    robust, but over time due to the 2/ND law and missed errors in copying,
    the robustness declined and continues to decline. This I
    think was anticipated from the beginning of the genetic code and several proofreading and repair machines were implanted into the code. But even
    these proofreading and repair systems are subject to errors over time. However, they still catch overwhelming numbers of mutations and corrects them, but not all. The evidence I think supports this. Still, each
    generation inherits the mutations from previous generations and develops
    new mutations, all of which is passed on down. At some distant time the genetic code in each species becomes increasingly less robust until reproduction
    ceases and we see this in many extinctions as recorded in the fossil
    record.

    Your invocation of the 2nd Law of Thermodynamics is a
    common creationist diversion. It started as a deliberate
    misrepresentation, and spread among the ignoratti such as
    yourself.

    The earth is awash in exergy. It has always been there
    for the taking. The 2nd law has naught to do with
    genetic drift. Extinction almost always happens due to
    environment & competition, humans included.

    You should ask an engineer to explain entropy and the 2nd
    Law to you.


    If one looks at the fossil record with _no_ biases, I think what we find
    is the abrupt appearance of most (if not all) species in the strata,
    then long periods of stasis followed by sudden disappearance.
    I think Dr Stephen J. Gould was an honest scientist who voiced what was actually observed in the fossil record without bias or an overriding commitment to convention.

    So Gould was an IDer. Who knew?

    --- SoupGate-Win32 v1.05
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  • From Bob Casanova@21:1/5 to All on Sat Jun 1 18:44:23 2024
    On Sat, 1 Jun 2024 18:39:35 -0700, the following appeared in
    talk.origins, posted by erik simpson
    <eastside.erik@gmail.com>:

    On 6/1/24 5:56 PM, El Kabong wrote:
    Ron Dean wrote:

    We've discussed this before. I think originally the genetic code was
    robust, but over time due to the 2/ND law and missed errors in copying,
    the robustness declined and continues to decline. This I
    think was anticipated from the beginning of the genetic code and several >>> proofreading and repair machines were implanted into the code. But even
    these proofreading and repair systems are subject to errors over time.
    However, they still catch overwhelming numbers of mutations and corrects >>> them, but not all. The evidence I think supports this. Still, each
    generation inherits the mutations from previous generations and develops >>> new mutations, all of which is passed on down. At some distant time the
    genetic code in each species becomes increasingly less robust until
    reproduction
    ceases and we see this in many extinctions as recorded in the fossil
    record.

    Your invocation of the 2nd Law of Thermodynamics is a
    common creationist diversion. It started as a deliberate
    misrepresentation, and spread among the ignoratti such as
    yourself.

    The earth is awash in exergy. It has always been there
    for the taking. The 2nd law has naught to do with
    genetic drift. Extinction almost always happens due to
    environment & competition, humans included.

    You should ask an engineer to explain entropy and the 2nd
    Law to you.


    If one looks at the fossil record with _no_ biases, I think what we find >>> is the abrupt appearance of most (if not all) species in the strata,
    then long periods of stasis followed by sudden disappearance.
    I think Dr Stephen J. Gould was an honest scientist who voiced what was
    actually observed in the fossil record without bias or an overriding
    commitment to convention.

    So Gould was an IDer. Who knew?

    Now, now. Gould wasn't/isn't the last word of authority, especially
    since he's been gone many years now, but his opinion that "replaying
    life's tape" would produce nothing like what we see is the antithesis of >intelligent design. Ron's misunderstanding of almost everything about >evolutionary biology (Gould included) is becoming legendary. He claims
    to be an engineer, but what kind?

    Sanitation? No competent *actual* engineer who understands
    thermodynamics would make the sort of egregious errors
    regarding the scope and application of the 2nd Law shown
    above.

    --

    Bob C.

    "The most exciting phrase to hear in science,
    the one that heralds new discoveries, is not
    'Eureka!' but 'That's funny...'"

    - Isaac Asimov

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  • From Ernest Major@21:1/5 to jillery on Sun Jun 2 08:28:48 2024
    On 01/06/2024 23:34, jillery wrote:
    So, who knows how many amino acids existed on the pre-biotic earth.

    Since you asked, apparently not you, which verifies Ernest Major's presumption expressed above.

    If you look at his original post you'll discover that he was implicitly claiming to know how many chemical species of amino acids existed on the pre-biotic earth.

    --
    alias Ernest Major

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  • From Athel Cornish-Bowden@21:1/5 to Ernest Major on Sun Jun 2 15:55:34 2024
    On 2024-05-31 19:00:00 +0000, Ernest Major said:

    On 31/05/2024 18:36, Ron Dean wrote:

    How the biologist responded to these "problems"? I've found nothing on
    the net. I found a book on Amazon for $300, but I'm not buying it. This
    symposium took place in 1966, so it's possible that the
    challenges have been met in the intervening years since then.

    At 10% of that price there is https://www.amazon.co.uk/Failures-Mathematical-Anti-Evolutionism-Jason-Rosenhouse/dp/1108820441


    The summary for chapter 4 is "We discuss the famous Wistar conference
    from 1966, in which high-level mathematical challenges to evolutionary
    theory were presented. We refute these challenges and discuss the
    historical significance of the conference in shaping modern
    mathematical anti-evolutionism."

    However, I know of several challenges that so far as I know have not
    been answered.
    The questions  are: There are over 500 amino acids found in nature, 50%
    left-handed, but if blind, aimless, unguided natural processes selected
    the 20 or 22 amino acids that used by all life what are
    the chances of these particular particular 20 left-handed amino acids
    being selected?  I realize there are theories offered to explain why
    only left-handed amino acids were selected, but what about the 20? Or
    is it possible that any other set of amino acids would have worked just
    as well?

    The last time you made this claim I tracked down the source of the 500 number, and found that this was 500 different amino acids which occur
    in living organisms. I asked you to consider how many of these amino
    acids existed in meaningful quantities (if at all) on the pre-biotic
    earth. I presume that you haven't done so.

    I've also brought to you attention that 20/22 amino acids used by all
    life is an oversimplification. All variants of the genetic code encode
    20 proteinogenic amino acids, so those are used by all life. Some
    prokaryotes have genetic codes that also encode a 21st amino acid, i.e. pyrolysine.

    Also selenocysteine.

    Wikipedia reports that the current consensus is that this originated
    in stem-archaeans, and has subsequently been horizontally transferred
    into some bacterial groups. A 22nd amino acid, selenocysteine, is also incorporated into proteins from the genetic code using a kludge. This
    is also not present in all organisms.

    However other amino acids are incorporated in proteins by
    post-translation modifications. I've previously brought to your
    attention that there's more hydroxyproline in human proteins than
    several canonical amino acids.

    Other amino acids play a role in biochemical metabolism.

    They you get into the weeds with amino acids such as canavanine (one of
    your 500). This is produced by some leguminous plants as an
    anti-herbivore toxin. It mimics arginine (a proteinogenic amino acid),
    from which it differs from by replacing a methylene bridge by an oxygen
    atom, resulting in it being incorporated into the herbivore's proteins
    to the detriment to their function. Specialist herbivores get round
    this either by having means of metabolising the canavanine before it
    gets near their protein synthesis machinery, or by improving the discrimination of their tRNA-arginine synthetases.

    There's a widespread belief that proteins are a relatively late
    addition to the biochemical repertoires, catalysis having been previous performed using RNAzymes. (RNAzymes are still essential for life.) If
    this is correct that would mean that amino acids and proteins can be
    added to the biochemical repertoires in gradual steps.

    People have studied the development of the genetic code, and inferred
    that the original code included fewer amino acids - perhaps as few as
    for. The addition of amino acids to the code would depend on
    availability and utility. The availability constraint biases the
    genetic code to simpler amino acids. The utility constraint biases the addition of amino acids to the code to amino acids which expand the functional range of proteins, i.e. which have properties (polar vs
    non-polar, basic vs acidic, hydrophobic via hydrophilic, etc.) not
    already found in the prior set.

    People have studied the robustness of the genetic code. The genetic
    code is not optimal for robustness against mutation, but is a lot
    better than a random one. Something similar may hold for the set of proteinogenic amino acids. Other sets might work perfectly well, but a
    set with, for example, only hydrophilic amino acids strikes me as
    likely to be relatively ineffective, or perhaps even not effective at
    all.


    --
    athel cb : Biochemical Evolution, Garland Science, 2016

    --- SoupGate-Win32 v1.05
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  • From Mark Isaak@21:1/5 to Ron Dean on Sun Jun 2 09:52:45 2024
    On 6/1/24 12:45 PM, Ron Dean wrote:
    Ernest Major wrote:
    On 31/05/2024 18:36, Ron Dean wrote:

    How the biologist responded to these "problems"? I've found nothing
    on the net. I found a book on Amazon for $300, but I'm not buying it.
    This symposium took place in 1966, so it's possible that the
    challenges have been met in the intervening years since then.

    At 10% of that price there is
    https://www.amazon.co.uk/Failures-Mathematical-Anti-Evolutionism-Jason-Rosenhouse/dp/1108820441
    After I check the local library I'll look into this.

    The summary for chapter 4 is "We discuss the famous Wistar conference
    from 1966, in which high-level mathematical challenges to evolutionary
    theory were presented. We refute these challenges and discuss the
    historical significance of the conference in shaping modern
    mathematical anti-evolutionism."

    Where there is mathematics involved, how is the math challenged? If not
    the math then what?
    I don't think it's fair to call someone an anti-evolutionist.

    You have repeatedly argued that a person's presumed motives, even when
    there is no evidence that the presumption is true, is of utmost
    importance in evaluating their arguments. So your complaint about
    calling someone who is anti-evolution an "anti-evolutionist" is grossly hypocritical, in addition to bordering on the absurd.

    This is a
    disparagement meant to discredit an opposition without a hearing. It's
    like a court where the prosecutor presents his case, but  a defense is
    not allowed. But a fair decision is expected.

    But you cannot challenge the mathematics. What is the chance of a single functional protein can form through unguided, random and aimless
    processes?

    That's easy. The chance is one. We know that a great variety of proteins
    can form from aimless processes. And there are also endless
    opportunities for any of them to find a function. And there are
    well-known non-random processes that can adjust the proteins (and
    perhaps the functions) to make them even more efficient. Anyone who
    found odds significantly less than one is not doing good mathematics,
    and must be challenged.

    For example, in the pre-biotic earth the first protein of say
    150 (the average number amino acids in a protein is 500-400) amino acids
    in a specific order is needed. Even in an ocean of amino acids and 4.5 billion years. It's said  it would be less chance than the number atoms
    in the known universe. As you know in the pre-biotic universe there is
    no natural selection.
    "......we can calculate the probability of building our very modest
    protein."

    https://www.youtube.com/watch?v=W1_KEVaCyaAfunctional protein to be 1 in 10^164.

    Remember, this is only one protein, and life requires hundreds of
    proteins".

    https://www.str.org/w/building-a-protein-by-chance

    I think this is where intelligence comes into play, there is no more
    simpler explanation!
    Where is Ocham's razor?

    Ocham's razor is not about simplicity; it is about unnecessary entities.
    You can't find the razor because you yourself have thrown it out.

    [big snip]

    The truth is, information is degraded by errors, mistakes and copying.

    The truth is, information is *created* by errors and mistakes in copying.

    You only think you reject evolution. In truth, you don't know enough
    about evolution to reject more than the word. What you reject has
    nothing to do with evolution.

    --
    Mark Isaak
    "Wisdom begins when you discover the difference between 'That
    doesn't make sense' and 'I don't understand.'" - Mary Doria Russell

    --- SoupGate-Win32 v1.05
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  • From Ernest Major@21:1/5 to Athel Cornish-Bowden on Sun Jun 2 19:50:32 2024
    On 02/06/2024 14:55, Athel Cornish-Bowden wrote:
    On 2024-05-31 19:00:00 +0000, Ernest Major said:

    On 31/05/2024 18:36, Ron Dean wrote:

    How the biologist responded to these "problems"? I've found nothing
    on the net. I found a book on Amazon for $300, but I'm not buying it.
    This symposium took place in 1966, so it's possible that the
    challenges have been met in the intervening years since then.

    At 10% of that price there is
    https://www.amazon.co.uk/Failures-Mathematical-Anti-Evolutionism-Jason-Rosenhouse/dp/1108820441

    The summary for chapter 4 is "We discuss the famous Wistar conference
    from 1966, in which high-level mathematical challenges to evolutionary
    theory were presented. We refute these challenges and discuss the
    historical significance of the conference in shaping modern
    mathematical anti-evolutionism."

    However, I know of several challenges that so far as I know have not
    been answered.
    The questions  are: There are over 500 amino acids found in nature,
    50% left-handed, but if blind, aimless, unguided natural processes
    selected the 20 or 22 amino acids that used by all life what are
    the chances of these particular particular 20 left-handed amino acids
    being selected?  I realize there are theories offered to explain why
    only left-handed amino acids were selected, but what about the 20? Or
    is it possible that any other set of amino acids would have worked
    just as well?

    The last time you made this claim I tracked down the source of the 500
    number, and found that this was 500 different amino acids which occur
    in living organisms. I asked you to consider how many of these amino
    acids existed in meaningful quantities (if at all) on the pre-biotic
    earth. I presume that you haven't done so.

    I've also brought to you attention that 20/22 amino acids used by all
    life is an oversimplification. All variants of the genetic code encode
    20 proteinogenic amino acids, so those are used by all life. Some
    prokaryotes have genetic codes that also encode a 21st amino acid,
    i.e. pyrolysine.

    Also selenocysteine.

    Mentioned 2 sentences later.

     Wikipedia reports that the current consensus is that this originated
    in stem-archaeans, and has subsequently been horizontally transferred
    into some bacterial groups. A 22nd amino acid, selenocysteine, is also
    incorporated into proteins from the genetic code using a kludge. This
    is also not present in all organisms.

    However other amino acids are incorporated in proteins by
    post-translation modifications. I've previously brought to your
    attention that there's more hydroxyproline in human proteins than
    several canonical amino acids.

    Other amino acids play a role in biochemical metabolism.

    They you get into the weeds with amino acids such as canavanine (one
    of your 500). This is produced by some leguminous plants as an
    anti-herbivore toxin. It mimics arginine (a proteinogenic amino acid),
    from which it differs from by replacing a methylene bridge by an
    oxygen atom, resulting in it being incorporated into the herbivore's
    proteins to the detriment to their function. Specialist herbivores get
    round this either by having means of metabolising the canavanine
    before it gets near their protein synthesis machinery, or by improving
    the discrimination of their tRNA-arginine synthetases.

    There's a widespread belief that proteins are a relatively late
    addition to the biochemical repertoires, catalysis having been
    previous performed using RNAzymes. (RNAzymes are still essential for
    life.) If this is correct that would mean that amino acids and
    proteins can be added to the biochemical repertoires in gradual steps.

    People have studied the development of the genetic code, and inferred
    that the original code included fewer amino acids - perhaps as few as
    for. The addition of amino acids to the code would depend on
    availability and utility. The availability constraint biases the
    genetic code to simpler amino acids. The utility constraint biases the
    addition of amino acids to the code to amino acids which expand the
    functional range of proteins, i.e. which have properties (polar vs
    non-polar, basic vs acidic, hydrophobic via hydrophilic, etc.) not
    already found in the prior set.

    People have studied the robustness of the genetic code. The genetic
    code is not optimal for robustness against mutation, but is a lot
    better than a random one. Something similar may hold for the set of
    proteinogenic amino acids. Other sets might work perfectly well, but a
    set with, for example, only hydrophilic amino acids strikes me as
    likely to be relatively ineffective, or perhaps even not effective at
    all.



    --
    alias Ernest Major

    --- SoupGate-Win32 v1.05
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  • From Athel Cornish-Bowden@21:1/5 to Ernest Major on Mon Jun 3 09:27:28 2024
    On 2024-06-02 18:50:32 +0000, Ernest Major said:

    On 02/06/2024 14:55, Athel Cornish-Bowden wrote:
    On 2024-05-31 19:00:00 +0000, Ernest Major said:

    On 31/05/2024 18:36, Ron Dean wrote:

    How the biologist responded to these "problems"? I've found nothing on >>>> the net. I found a book on Amazon for $300, but I'm not buying it. This >>>> symposium took place in 1966, so it's possible that the
    challenges have been met in the intervening years since then.

    At 10% of that price there is
    https://www.amazon.co.uk/Failures-Mathematical-Anti-Evolutionism-Jason-Rosenhouse/dp/1108820441


    The summary for chapter 4 is "We discuss the famous Wistar conference
    from 1966, in which high-level mathematical challenges to evolutionary
    theory were presented. We refute these challenges and discuss the
    historical significance of the conference in shaping modern
    mathematical anti-evolutionism."

    However, I know of several challenges that so far as I know have not
    been answered.
    The questions  are: There are over 500 amino acids found in nature, 50% >>>> left-handed, but if blind, aimless, unguided natural processes selected >>>> the 20 or 22 amino acids that used by all life what are
    the chances of these particular particular 20 left-handed amino acids
    being selected?  I realize there are theories offered to explain why
    only left-handed amino acids were selected, but what about the 20? Or
    is it possible that any other set of amino acids would have worked just >>>> as well?

    The last time you made this claim I tracked down the source of the 500
    number, and found that this was 500 different amino acids which occur
    in living organisms. I asked you to consider how many of these amino
    acids existed in meaningful quantities (if at all) on the pre-biotic
    earth. I presume that you haven't done so.

    I've also brought to you attention that 20/22 amino acids used by all
    life is an oversimplification. All variants of the genetic code encode
    20 proteinogenic amino acids, so those are used by all life. Some
    prokaryotes have genetic codes that also encode a 21st amino acid, i.e.
    pyrolysine.

    Also selenocysteine.

    Mentioned 2 sentences later.

    True. I looked but I didn't see it. Getting old, I fear.

     Wikipedia reports that the current consensus is that this originated
    in stem-archaeans, and has subsequently been horizontally transferred
    into some bacterial groups. A 22nd amino acid, selenocysteine, is also
    incorporated into proteins from the genetic code using a kludge. This
    is also not present in all organisms.

    However other amino acids are incorporated in proteins by
    post-translation modifications. I've previously brought to your
    attention that there's more hydroxyproline in human proteins than
    several canonical amino acids.

    Other amino acids play a role in biochemical metabolism.

    They you get into the weeds with amino acids such as canavanine (one of
    your 500). This is produced by some leguminous plants as an
    anti-herbivore toxin. It mimics arginine (a proteinogenic amino acid),
    from which it differs from by replacing a methylene bridge by an oxygen
    atom, resulting in it being incorporated into the herbivore's proteins
    to the detriment to their function. Specialist herbivores get round
    this either by having means of metabolising the canavanine before it
    gets near their protein synthesis machinery, or by improving the
    discrimination of their tRNA-arginine synthetases.

    There's a widespread belief that proteins are a relatively late
    addition to the biochemical repertoires, catalysis having been previous
    performed using RNAzymes. (RNAzymes are still essential for life.) If
    this is correct that would mean that amino acids and proteins can be
    added to the biochemical repertoires in gradual steps.

    People have studied the development of the genetic code, and inferred
    that the original code included fewer amino acids - perhaps as few as
    for. The addition of amino acids to the code would depend on
    availability and utility. The availability constraint biases the
    genetic code to simpler amino acids. The utility constraint biases the
    addition of amino acids to the code to amino acids which expand the
    functional range of proteins, i.e. which have properties (polar vs
    non-polar, basic vs acidic, hydrophobic via hydrophilic, etc.) not
    already found in the prior set.

    People have studied the robustness of the genetic code. The genetic
    code is not optimal for robustness against mutation, but is a lot
    better than a random one. Something similar may hold for the set of
    proteinogenic amino acids. Other sets might work perfectly well, but a
    set with, for example, only hydrophilic amino acids strikes me as
    likely to be relatively ineffective, or perhaps even not effective at
    all.


    --
    athel cb : Biochemical Evolution, Garland Science, 2016

    --- SoupGate-Win32 v1.05
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  • From Kerr-Mudd, John@21:1/5 to Ron Dean on Mon Jun 3 20:33:40 2024
    On Mon, 3 Jun 2024 13:17:29 -0400
    Ron Dean <rondean-noreply@gmail.com> wrote:

    Martin Harran wrote:
    On Sun, 2 Jun 2024 11:15:24 -0400, Ron Dean
    <rondean-noreply@gmail.com> wrote:

    [snip for focus]

    In my youth I came to accept evolution as a fact. But after reading a
    book by Dr Michael Denton, on a challenge, I began to question the
    "evidence" for evolution and that's where I am today.

    When forming my own views on a subject, I always make an effort to understand the various views on the subject. For example, on my
    bookshelf, 'The Selfish Gene' by Richard Dawkins sits alongside his
    'God Delusion'; Jerry Coyne's 'Why Evolution is True' sits alongside
    his ' Faith Versus Fact'; Francis Collins's 'The Language of God' sits alongside Stephen Meyer's 'God Hypothesis'.

    What books or authors have you read you that argue against Intelligent Design?

    I love reading, especially Science Fiction books + movies. I've read:
    The Blind Watchmaker - Dawkins
    the God Delusion -Dawkins
    The language of Life - Collins
    and 2 or 3 others, 25+ years ago - the titles I do not recall, but one
    []
    not a lot, and you need something more up-to-date -

    Try this one: - https://www.amazon.co.uk/Evolution-Ladybird-Expert-Book/dp/0718186281
    --
    Bah, and indeed Humbug.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From El Kabong@21:1/5 to Ron Dean on Mon Jun 3 18:14:08 2024
    Ron Dean wrote:
    jillery wrote:
    On Sun, 2 Jun 2024 11:15:24 -0400, Ron Dean <rondean-noreply@gmail.com> wrote:
    jillery wrote:

    ...
    Once again, you conveniently forgot to mention that genetic
    information is corrected and amplified by reproduction and natural
    selection, no intelligence necessary.

    No, it is not corrected through reproduction,


    Read for comprehension. Yes, it is corrected through reproduction
    *and* natural selection. Reproduction amplifies more fit mutations, natural selection removes less fit mutations. I know you know this.

    Yes, and I've recognized and pointed this out. There are countless
    errors and mutations, caused by radiation, copy error, omissions, but
    the overwhelming majority or proofread and repaired. But there are a few mutations that the P&R machines does not detect. These mutations are
    passed on
    to offspring.

    No, those mutations are not passed on to offspring, for
    reasons that have been explained to you several times.

    The mutations that are repaired and corrected are ones
    that happen in mitosis, the cell division process. But,
    in multicellular organisms, these cells do not reproduce.
    The cells that reproduce are gametes. They are formed in
    the process of meosis, in which genetic variations and
    mutations can be passed on. They are not "repaired" to
    look like the parent genome, because they are supposed to
    be different. The function of the whole process is to
    produce variations in offspring because that drives the
    whole process of adaptation and evolution.

    Life has evolved the ability to evolve.

    Do you have any idea why sexual reproduction is so
    common?

    Of course, you will ignore this and repeat your false
    assertions over and over because you are incapable of
    learning and adapting.

    If you are resolutely determined to remain ignorant, you
    will succeed.

    <snip>

    OK, in regards to the Cambrian Explosion, there were oceans where an abundance of new, unknown complex organisms abruptly appeared
    (geologically speaking) where prior to this, there were billions of
    years where only single cell organisms were found in the strata.

    No, there were multi-celled organisms long before the
    Cambrian. They were soft-bodied and left very few
    fossils, but there are some.

    This has also been explained to you, and your ignorance
    has prevailed over enlightenment yet again.


    Not
    only was this and explosion of complex organisms, this was accompanied
    with an explosion of instructive information. The origin of which is
    unknown.

    You seem to think evolution and the geneneration of
    genetic "information" are separate and unrelated
    processes. They are not. The generation of genetic
    "information" is the process of evolution itself. What
    else do you think it is that evolves?

    This has also been explained to you before. But again,
    you will always favor the ignorance of IDism.

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  • From Chris Thompson@21:1/5 to Athel Cornish-Bowden on Mon Jun 3 22:41:31 2024
    Athel Cornish-Bowden wrote:
    On 2024-06-02 18:50:32 +0000, Ernest Major said:

    On 02/06/2024 14:55, Athel Cornish-Bowden wrote:
    On 2024-05-31 19:00:00 +0000, Ernest Major said:

    On 31/05/2024 18:36, Ron Dean wrote:

    How the biologist responded to these "problems"? I've found nothing
    on the net. I found a book on Amazon for $300, but I'm not buying
    it. This symposium took place in 1966, so it's possible that the
    challenges have been met in the intervening years since then.

    At 10% of that price there is
    https://www.amazon.co.uk/Failures-Mathematical-Anti-Evolutionism-Jason-Rosenhouse/dp/1108820441


    The summary for chapter 4 is "We discuss the famous Wistar
    conference from 1966, in which high-level mathematical challenges to
    evolutionary theory were presented. We refute these challenges and
    discuss the historical significance of the conference in shaping
    modern mathematical anti-evolutionism."

    However, I know of several challenges that so far as I know have
    not been answered.
    The questions  are: There are over 500 amino acids found in nature, >>>>> 50% left-handed, but if blind, aimless, unguided natural processes
    selected the 20 or 22 amino acids that used by all life what are
    the chances of these particular particular 20 left-handed amino
    acids being selected?  I realize there are theories offered to
    explain why only left-handed amino acids were selected, but what
    about the 20? Or is it possible that any other set of amino acids
    would have worked just as well?

    The last time you made this claim I tracked down the source of the
    500 number, and found that this was 500 different amino acids which
    occur in living organisms. I asked you to consider how many of these
    amino acids existed in meaningful quantities (if at all) on the
    pre-biotic earth. I presume that you haven't done so.

    I've also brought to you attention that 20/22 amino acids used by
    all life is an oversimplification. All variants of the genetic code
    encode 20 proteinogenic amino acids, so those are used by all life.
    Some prokaryotes have genetic codes that also encode a 21st amino
    acid, i.e. pyrolysine.

    Also selenocysteine.

    Mentioned 2 sentences later.

    True. I looked but I didn't see it. Getting old, I fear.

    Ron Dean will tell you that means your entropy is increasing.

    Chris
    snip

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  • From Chris Thompson@21:1/5 to Ron Dean on Mon Jun 3 22:47:29 2024
    Ron Dean wrote:
    erik simpson wrote:
    On 6/2/24 9:14 AM, Ron Dean wrote:
    El Kabong wrote:
    Ron Dean wrote:

    We've discussed this before. I think originally the genetic code was >>>>> robust, but over time due to the 2/ND law and missed errors in
    copying,
    the robustness declined and continues to decline. This I
    think was anticipated from the beginning of the genetic code and
    several
    proofreading and repair machines were implanted into the code. But
    even
    these proofreading and repair systems are subject to errors over time. >>>>> However, they still catch overwhelming numbers of mutations and
    corrects
    them, but not all. The evidence I think supports this. Still, each
    generation inherits the mutations from previous generations and
    develops
    new mutations, all of which is passed on down. At some distant time
    the
    genetic code in each species becomes increasingly less robust until
    reproduction
    ceases and we see this in many extinctions as recorded in the fossil >>>>> record.

    Your invocation of the 2nd Law of Thermodynamics is a
    common creationist diversion.  It started as a deliberate
    misrepresentation, and spread among the ignoratti such as
    yourself.
    ;
    That's an easy claim to make where no proof is offered. It's just you
    stupid opinion!

    The earth is awash in exergy.  It has always been there
    for the taking.  The 2nd law has naught to do with
    genetic drift.
    ;
    Errors, omissions and other mutations happen, this is running down
    this is increasing entropy.
    The 2/ND law was stated by a locomotive engineer who observed that in
    a _closed_ system energy always runs down, this is increasing
    entropy. Heat flows from hot to cooler, never the reverse.

    You are right the earth is an open system, receiving energy from the
    sun, but even in open systems increasing entropy occurs. For example:
    a house, after being deserted runs down and over time becomes
    completely disordered this is increasing entropy, which is in accord
    with the 2/nd law.
    A tree grows from a seed this is decreasing entropy receiving energy
    from the sun, and the tree
    grows matures and then dies. Now even though the dead tree continues
    to receive solar energy it
    will decay and turn to dust. How do you explain that in terms of the
    2/nd law?

    Extinction almost always happens due to
    environment & competition, humans included.

    You should ask an engineer to explain entropy and the 2nd
    Law to you.

    I am an engineer MsEE.  For your information according to the 2/ND
    law of thermodynamics the earth is an open system, but the second law
    was originally defined by Carnot a steam engine engineer. He defined
    the 2/ND law in terms of a closed system. He cared nothing about open
    systems.  But he, Carnot formulated the second law of thermodynamics.

    If one looks at the fossil record with _no_ biases, I think what we
    find
    is the abrupt appearance of most (if not all) species in the strata, >>>>> then long periods of stasis followed by sudden disappearance.
    I think Dr Stephen J. Gould was an honest scientist who voiced what
    was
    actually observed in the fossil record without bias or an overriding >>>>> commitment to convention.

    So Gould was an IDer.  Who knew?

    No, that's not my claim. Stephen Gould observed the traits and
    characteristics of the fossil record and he tried to interpret what
    he found to fit within the scope of evolution. He never changed his
    mind. He died an evolutionist.

    You must have encountered thermodynamics in your education, but you
    continue to refer to any deleterious changes as "due to entropy".

    So, deleterious change is not disorder?

    How does removing glutamic acid from a particular sequence and replacing
    it with valine increase entropy? Show your math, please.

    Chris

    snip

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  • From *Hemidactylus*@21:1/5 to Martin Harran on Wed Jun 5 03:10:42 2024
    Martin Harran <martinharran@gmail.com> wrote:
    On Sun, 2 Jun 2024 11:15:24 -0400, Ron Dean
    <rondean-noreply@gmail.com> wrote:

    [snip for focus]

    In my youth I came to accept evolution as a fact. But after reading a
    book by Dr Michael Denton, on a challenge, I began to question the
    "evidence" for evolution and that's where I am today.

    When forming my own views on a subject, I always make an effort to
    understand the various views on the subject.

    When someone points to your guru having eugenics based views you belittle
    them by comparing them to Ron Dean and when presented with actual evidence quoted directly from the source you avoid actually deep diving in and
    instead tap dance with irrelevancies like the practice of FGM. So much for understanding those various views that might go against your own
    confirmation bias. But go on and lecture Ron Dean on your virtues.

    For example, on my
    bookshelf, 'The Selfish Gene' by Richard Dawkins sits alongside his
    'God Delusion'; Jerry Coyne's 'Why Evolution is True' sits alongside
    his ' Faith Versus Fact';

    So what of his discussion of yolking genes in the former versus his bugbear Templeton in the latter then?

    Francis Collins's 'The Language of God' sits
    alongside Stephen Meyer's 'God Hypothesis'.

    What books or authors have you read you that argue against Intelligent Design?

    [Â…]



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  • From J. J. Lodder@21:1/5 to LDagget on Wed Jun 5 10:22:52 2024
    LDagget <j.nobel.daggett@gmail.com> wrote:

    Chris Thompson wrote:

    Ron Dean wrote:
    erik simpson wrote:

    So, deleterious change is not disorder?

    How does removing glutamic acid from a particular sequence and
    replacing

    it with valine increase entropy? Show your math, please.

    Chris

    I want to note how much I miss Paul Gans and other thermodynamics
    experts.

    Past expertise is always better than present one, eh?

    Jan

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  • From Ernest Major@21:1/5 to Martin Harran on Thu Jun 6 10:24:30 2024
    On 05/06/2024 12:37, Martin Harran wrote:
    'The Selfish Gene' by Richard Dawkins. A bit dated now and weak in
    some areas like altruism but I have a soft spot for it as it was the second-ever book I read on evolution (see below for my first book.)

    The Dawkins' books that I'd recommend are "The Extended Phenotype"
    (written for biologists, rather the general populace, but I found it accessible, and covering somewhat of the same ground as "The Selfish
    Gene"), and "The Ancestor's Tale" (a Gould essay collection written by
    Dawkins, with a unifying theme of consecutive sister groups to Homo
    sapiens).

    The weakness I found in "The Selfish Gene" is that it confused the individual/group selection dichotomy with the replicator/vehicle
    dichotomy. That's fixed in "The Extended Phenotype".

    --
    alias Ernest Major

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  • From Athel Cornish-Bowden@21:1/5 to Ernest Major on Thu Jun 6 12:34:14 2024
    On 2024-06-06 09:24:30 +0000, Ernest Major said:

    On 05/06/2024 12:37, Martin Harran wrote:
    'The Selfish Gene' by Richard Dawkins. A bit dated now and weak in
    some areas like altruism but I have a soft spot for it as it was the
    second-ever book I read on evolution (see below for my first book.)

    The Dawkins' books that I'd recommend are "The Extended Phenotype"

    Absolutely. In many respects his best, but little known, book

    (written for biologists, rather the general populace, but I found it accessible, and covering somewhat of the same ground as "The Selfish
    Gene"), and "The Ancestor's Tale" (a Gould essay collection written by Dawkins, with a unifying theme of consecutive sister groups to Homo
    sapiens).

    The weakness I found in "The Selfish Gene" is that it confused the individual/group selection dichotomy with the replicator/vehicle
    dichotomy. That's fixed in "The Extended Phenotype".


    --
    athel cb : Biochemical Evolution, Garland Science, 2016

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  • From Ernest Major@21:1/5 to Ron Dean on Thu Jun 6 13:23:12 2024
    On 05/06/2024 17:42, Ron Dean wrote:

    How many have you read pointing out the flaws
    in evolutionary theory?


    The problem with that question is you and other cdesign proponentsists
    have a very flawed concept of what qualifies as flaws in evolutionary
    theory.

    IOW - None!

    Is that an admission that "Evolution: A Theory in Crisis", "Evolution on
    Trial" and the "Neck of the Giraffe" don't point out any flaws in
    evolutionary theory?

    --
    alias Ernest Major

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  • From Athel Cornish-Bowden@21:1/5 to John Harshman on Sun Jun 9 10:32:25 2024
    On 2024-06-08 20:51:39 +0000, John Harshman said:

    On 6/8/24 1:38 PM, Ron Dean wrote:
    jillery wrote:
    On Fri, 7 Jun 2024 11:24:58 -0400, Ron Dean
    <rondean-noreply@gmail.com> wrote:

    jillery wrote:
    On Wed, 5 Jun 2024 12:42:57 -0400, Ron Dean
    <rondean-noreply@gmail.com> wrote:

    How many have you read pointing out the flaws
    in evolutionary theory?


    The problem with that question is you and other cdesign proponentsists >>>>>>> have a very flawed concept of what qualifies as flaws in evolutionary >>>>>>> theory.

    IOW - None!


    IOW - when someone says "stasis is the exact opposite of gradual
    change", it shows they have no idea what the words even mean,
    nevermind what they're talking about, nevermind what the people they >>>>> quote are talking about.

    Then please explain precisely what Gould meant by stasis and equilibrium. >>>

    Why sure, just as soon as you explain precisely what you meant by
    stasis and equilibrium.

    I accepted Gould's definition, stasis means stability. He points out
    that historically when paleontologist were faced with stasis they saw
    it as "no data".

    But as I recall, the scientist on Darwin's day pointed this out to
    Darwin, so he was aware of this. But it was soon overlooked and ignored
    by scientist while searching for evidence to support Darwin's theory. I
    think that explains the "no data".

    Equilibrium was preceded and followed stasis. So punctuated
    equilibrium, as I understood Dr Gould's view, he saw periods of stasis
    followed by punctuated (rapid appearance of new species (geologically
    speaking)), then long spans of stasis (little or no change) then sudden
    disappearance.

    IOW stasis marked as an "x species" which was _punctuated_ (evolved
    rapidly) into a new stable "y species".  He calls punctuated which is
    not observe as _peripherical_isolatiates_.
    If I wrong then please explain why.

    Mostly OK, if oddly stated. A few problems

    1. "Sudden disappearance" is not in any way a part of the theory.

    2. You have the equilibrium part all wrong. The equilibrium is stasis.

    3. The term is "peripheral isolates", adopted from Ernst Mayr, and I'm
    not sure you know what they are. They're just small, geographically
    isolated populations on the periphery of a species range.

    Speciation in such cases can happen remarkably rapidly. On the island
    of Madeira there are six races (the term they use, though they fit
    Mayr's definition of species) of mice, that cannot breed either with
    one another or with the common European mouse. They appear to have
    evolved within the past 1000 years (if you assume they are descended
    from mice introduced by the Vikings), or much less than that if they
    came with the Portuguese. (Madeira is an island with numerous deep
    valleys separated by high ground that mice can't cross.)

    Some peripheral isolates are in fact observed. If you look at the
    original publication, Eldredge N., Gould S.J. Punctuated equilibria: an alternative to phyletic gradualism. In: Schopf T.J.M. editor. Models of Paleobiology, 1972. p. 82-115, you will see that it produces a couple
    of examples of peripheral isolates, notably in a trilobite, Phacops
    rana.

    4. You should know that punctuated equilibria is not very popular with evolutionary biologists.


    --
    Athel -- French and British, living in Marseilles for 37 years; mainly
    in England until 1987.

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  • From Athel Cornish-Bowden@21:1/5 to John Harshman on Sun Jun 9 22:34:41 2024
    On 2024-06-09 19:51:44 +0000, John Harshman said:

    On 6/9/24 12:27 PM, Ron Dean wrote:
    Athel Cornish-Bowden wrote:
    On 2024-06-08 20:51:39 +0000, John Harshman said:

    On 6/8/24 1:38 PM, Ron Dean wrote:
    jillery wrote:
    On Fri, 7 Jun 2024 11:24:58 -0400, Ron Dean
    <rondean-noreply@gmail.com> wrote:

    jillery wrote:
    On Wed, 5 Jun 2024 12:42:57 -0400, Ron Dean
    <rondean-noreply@gmail.com> wrote:

    How many have you read pointing out the flaws
    in evolutionary theory?


    The problem with that question is you and other cdesign proponentsists
    have a very flawed concept of what qualifies as flaws in evolutionary
    theory.

    IOW - None!


    IOW - when someone says "stasis is the exact opposite of gradual >>>>>>>> change", it shows they have no idea what the words even mean,
    nevermind what they're talking about, nevermind what the people they >>>>>>>> quote are talking about.

    Then please explain precisely what Gould meant by stasis and equilibrium.


    Why sure, just as soon as you explain precisely what you meant by
    stasis and equilibrium.

    I accepted Gould's definition, stasis means stability. He points out >>>>> that historically when paleontologist were faced with stasis they saw >>>>> it as "no data".

    But as I recall, the scientist on Darwin's day pointed this out to
    Darwin, so he was aware of this. But it was soon overlooked and ignored >>>>> by scientist while searching for evidence to support Darwin's theory. I >>>>> think that explains the "no data".

    Equilibrium was preceded and followed stasis. So punctuated
    equilibrium, as I understood Dr Gould's view, he saw periods of stasis >>>>> followed by punctuated (rapid appearance of new species (geologically >>>>> speaking)), then long spans of stasis (little or no change) then sudden >>>>> disappearance.

    IOW stasis marked as an "x species" which was _punctuated_ (evolved
    rapidly) into a new stable "y species".  He calls punctuated which is >>>>> not observe as _peripherical_isolatiates_.
    If I wrong then please explain why.

    Mostly OK, if oddly stated. A few problems

    1. "Sudden disappearance" is not in any way a part of the theory.

    2. You have the equilibrium part all wrong. The equilibrium is stasis. >>>>
    3. The term is "peripheral isolates", adopted from Ernst Mayr, and I'm >>>> not sure you know what they are. They're just small, geographically
    isolated populations on the periphery of a species range.

    Speciation in such cases can happen remarkably rapidly. On the island
    of Madeira there are six races (the term they use, though they fit
    Mayr's definition of species) of mice, that cannot breed either with
    one another or with the common European mouse. They appear to have
    evolved within the past 1000 years (if you assume they are descended
    from mice introduced by the Vikings), or much less than that if they
    came with the Portuguese. (Madeira is an island with numerous deep
    valleys separated by high ground that mice can't cross.)

    I don't have a problem with this. I know about birds that surround an
    island each grope can cross breed with the a-joining population in both
    the fore and the back groups, but not beyond.

    I think you're trying to talk about ring species.

    He probably is, but the Madeira mice are not a ring species. None of
    the species can beed with any of the others.

    Two problems: that's not what jillery is talking about, and there are
    in fact no known examples of ring species of birds that surround an
    island.

     Some peripheral isolates are in fact observed. If you look at the
    original publication, Eldredge N., Gould S.J. Punctuated equilibria: an >>>> alternative to phyletic gradualism. In: Schopf T.J.M. editor. Models of >>>> Paleobiology, 1972. p. 82-115, you will see that it produces a couple
    of examples of peripheral isolates, notably in a trilobite, Phacops
    rana.

    4. You should know that punctuated equilibria is not very popular with >>>> evolutionary biologists.


    --
    Athel -- French and British, living in Marseilles for 37 years; mainly
    in England until 1987.

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  • From El Kabong@21:1/5 to Ron Dean on Wed Jun 12 20:28:35 2024
    Ron Dean wrote:

    Biological things are designoid: ‘Designoid
    objects that look designed, so much so that some people – probably,
    alas, most people – think that they are designed.

    Then again, there are your designoid objects that clearly
    look evolved. Like bird feet that evolved for different
    lifestyles, all from scaly dinosaur feet.

    Ron, you've got to know your designoid objects better.

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  • From J. J. Lodder@21:1/5 to LDagget on Thu Jun 13 13:19:39 2024
    LDagget <j.nobel.daggett@gmail.com> wrote:

    J. J. Lodder wrote:

    LDagget <j.nobel.daggett@gmail.com> wrote:

    Chris Thompson wrote:

    Ron Dean wrote:
    erik simpson wrote:

    So, deleterious change is not disorder?

    How does removing glutamic acid from a particular sequence and
    replacing

    it with valine increase entropy? Show your math, please.

    Chris

    I want to note how much I miss Paul Gans and other thermodynamics
    experts.

    Past expertise is always better than present one, eh?

    Jan

    Oh I realize that a number of people here have expertise in
    thermodynamics, but it used to go deeper. Further, it included some with excellent skills in communication, the sort that sometimes arises from decades of teaching both freshman classes and graduate level classes.

    You might have remembered that I did participate in those discussions,
    long long ago, before I more or less gave up on t.o.

    Jan

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