• Re: "Thermodynamic Limitations on the Natural Emergence of Long Chain M

    From Kerr-Mudd, John@21:1/5 to MarkE on Thu Jul 17 09:56:37 2025
    On Thu, 17 Jul 2025 15:44:28 +1000
    MarkE <me22over7@gmail.com> wrote:

    From this recent EN article: https://evolutionnews.org/2025/07/new-article-from-james-tour-undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide chain elongation under prebiotic conditions is very long. Yang et al. (2025) identify numerous barriers to sustained polypeptide growth, including
    the formation of non-peptide linkages and cyclic structures, stringent environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than
    one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think an example of the ongoing scrutiny and developing fundamental challenges to
    OoL. My prediction is these will continue to emerge, weakening
    materialistic abiogenesis and strengthening ID's core claim.



    ID has no science; it doesn't explain anything. It's classic God of the
    Gaps. But you've been told before. PS get a better news source.


    --
    Bah, and indeed Humbug.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Athel Cornish-Bowden@21:1/5 to John on Thu Jul 17 12:53:51 2025
    On 2025-07-17 08:56:37 +0000, Kerr-Mudd, John said:

    On Thu, 17 Jul 2025 15:44:28 +1000
    MarkE <me22over7@gmail.com> wrote:

    From this recent EN article:
    https://evolutionnews.org/2025/07/new-article-from-james-tour-undermines-a-pillar-of-origin-of-life-theories/


    'In comparison to a protein’s half-life, the rate of polypeptide chain
    elongation under prebiotic conditions is very long. Yang et al. (2025)
    identify numerous barriers to sustained polypeptide growth, including
    the formation of non-peptide linkages and cyclic structures, stringent
    environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than
    one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter
    half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think an
    example of the ongoing scrutiny and developing fundamental challenges to
    OoL. My prediction is these will continue to emerge, weakening
    materialistic abiogenesis and strengthening ID's core claim.



    ID has no science; it doesn't explain anything. It's classic God of the
    Gaps. But you've been told before. PS get a better news source.

    And people interested in serious science don't look for it in Evolution News.

    --
    athel cb : Biochemical Evolution, Garland Science, 2016

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Kalkidas@21:1/5 to Athel Cornish-Bowden on Thu Jul 17 12:44:11 2025
    On 7/17/2025 3:53 AM, Athel Cornish-Bowden wrote:
    On 2025-07-17 08:56:37 +0000, Kerr-Mudd, John said:

    On Thu, 17 Jul 2025 15:44:28 +1000
    MarkE <me22over7@gmail.com> wrote:

    From this recent EN article:
    https://evolutionnews.org/2025/07/new-article-from-james-tour-
    undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide chain
    elongation under prebiotic conditions is very long. Yang et al. (2025)
    identify numerous barriers to sustained polypeptide growth, including
    the formation of non-peptide linkages and cyclic structures, stringent
    environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than
    one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter
    half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think an >>> example of the ongoing scrutiny and developing fundamental challenges to >>> OoL. My prediction is these will continue to emerge, weakening
    materialistic abiogenesis and strengthening ID's core claim.



    ID has no science; it doesn't explain anything. It's classic God of the
    Gaps.  But you've been told before. PS get a better news source.

    And people interested in serious science don't look for it in Evolution
    News.


    The evolutionnews.org article merely summarizes a peer-reviewed
    scientific paper, for which the link is given.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Kalkidas@21:1/5 to John on Thu Jul 17 12:48:40 2025
    On 7/17/2025 1:56 AM, Kerr-Mudd, John wrote:
    On Thu, 17 Jul 2025 15:44:28 +1000
    MarkE <me22over7@gmail.com> wrote:

    From this recent EN article:
    https://evolutionnews.org/2025/07/new-article-from-james-tour-undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide chain
    elongation under prebiotic conditions is very long. Yang et al. (2025)
    identify numerous barriers to sustained polypeptide growth, including
    the formation of non-peptide linkages and cyclic structures, stringent
    environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than
    one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter
    half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think an
    example of the ongoing scrutiny and developing fundamental challenges to
    OoL. My prediction is these will continue to emerge, weakening
    materialistic abiogenesis and strengthening ID's core claim.



    ID has no science; it doesn't explain anything. It's classic God of the
    Gaps. But you've been told before. PS get a better news source.



    Hackneyed much?

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Kalkidas@21:1/5 to MarkE on Thu Jul 17 12:25:12 2025
    On 7/16/2025 10:44 PM, MarkE wrote:
    From this recent EN article: https://evolutionnews.org/2025/07/new- article-from-james-tour-undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide chain elongation under prebiotic conditions is very long. Yang et al. (2025) identify numerous barriers to sustained polypeptide growth, including
    the formation of non-peptide linkages and cyclic structures, stringent environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than
    one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think an example of the ongoing scrutiny and developing fundamental challenges to
    OoL. My prediction is these will continue to emerge, weakening
    materialistic abiogenesis and strengthening ID's core claim.

    Note that the replies to your post offer no refutation of any of the
    points of the paper, Just name-calling and genetic fallacies.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Kalkidas@21:1/5 to Martin Harran on Thu Jul 17 12:46:47 2025
    On 7/17/2025 11:23 AM, Martin Harran wrote:
    On Thu, 17 Jul 2025 15:44:28 +1000, MarkE <me22over7@gmail.com> wrote:

    From this recent EN article:
    https://evolutionnews.org/2025/07/new-article-from-james-tour-undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide chain
    elongation under prebiotic conditions is very long. Yang et al. (2025)
    identify numerous barriers to sustained polypeptide growth, including
    the formation of non-peptide linkages and cyclic structures, stringent
    environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than
    one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter
    half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think an
    example of the ongoing scrutiny and developing fundamental challenges to
    OoL. My prediction is these will continue to emerge, weakening
    materialistic abiogenesis and strengthening ID's core claim.


    You have clearly still not grasped the principle that you cannot
    insist that *must have been* the butler who killed her ladyship simply because you have shown it is very unlikely that his lordship did it.


    Nature simultaneously destroys what it (allegedly) creates. And it
    destroys it faster than it (allegedly) creates it.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Ernest Major@21:1/5 to MarkE on Thu Jul 17 23:16:18 2025
    On 17/07/2025 06:44, MarkE wrote:
    From this recent EN article: https://evolutionnews.org/2025/07/new- article-from-james-tour-undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide chain elongation under prebiotic conditions is very long. Yang et al. (2025) identify numerous barriers to sustained polypeptide growth, including
    the formation of non-peptide linkages and cyclic structures, stringent environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than
    one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think an example of the ongoing scrutiny and developing fundamental challenges to
    OoL. My prediction is these will continue to emerge, weakening
    materialistic abiogenesis and strengthening ID's core claim.



    Given that it is widely believed that proteins were a late addition to
    the biological repertoire why do you accept the claim that this is a
    challenge to spontaneous abiogenesis?

    --
    alias Ernest Major

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Athel Cornish-Bowden@21:1/5 to MarkE on Fri Jul 18 12:28:16 2025
    On 2025-07-18 04:30:11 +0000, MarkE said:

    On 18/07/2025 5:25 am, Kalkidas wrote:
    On 7/16/2025 10:44 PM, MarkE wrote:
     From this recent EN article: https://evolutionnews.org/2025/07/new-
    article-from-james-tour-undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide chain >>> elongation under prebiotic conditions is very long. Yang et al. (2025)
    identify numerous barriers to sustained polypeptide growth, including
    the formation of non-peptide linkages and cyclic structures, stringent
    environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than
    one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter
    half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think
    an example of the ongoing scrutiny and developing fundamental
    challenges to OoL. My prediction is these will continue to emerge,
    weakening materialistic abiogenesis and strengthening ID's core claim.

    Note that the replies to your post offer no refutation of any of the
    points of the paper, Just name-calling and genetic fallacies.


    Noted; not unusual. Pity - Athel could add some content to this discussion.

    Of course I could, because I know what the laws of thermodynamics say,
    but what would be the point?

    --
    athel cb : Biochemical Evolution, Garland Science, 2016

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Kalkidas@21:1/5 to Martin Harran on Sat Jul 19 11:38:07 2025
    On 7/17/2025 11:37 PM, Martin Harran wrote:
    On Thu, 17 Jul 2025 12:46:47 -0700, Kalkidas <eat@joes.pub> wrote:

    On 7/17/2025 11:23 AM, Martin Harran wrote:
    On Thu, 17 Jul 2025 15:44:28 +1000, MarkE <me22over7@gmail.com> wrote:

    From this recent EN article:
    https://evolutionnews.org/2025/07/new-article-from-james-tour-undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide chain >>>> elongation under prebiotic conditions is very long. Yang et al. (2025) >>>> identify numerous barriers to sustained polypeptide growth, including
    the formation of non-peptide linkages and cyclic structures, stringent >>>> environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than
    one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter
    half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think an >>>> example of the ongoing scrutiny and developing fundamental challenges to >>>> OoL. My prediction is these will continue to emerge, weakening
    materialistic abiogenesis and strengthening ID's core claim.


    You have clearly still not grasped the principle that you cannot
    insist that *must have been* the butler who killed her ladyship simply
    because you have shown it is very unlikely that his lordship did it.


    Nature simultaneously destroys what it (allegedly) creates. And it
    destroys it faster than it (allegedly) creates it.

    If true then that means that the Intelligent Designer gets it wrong
    more often than he gets it right.


    What's "wrong" about it? Do you think this universe was created to be
    some kind of amusement park?

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From vallor@21:1/5 to Kalkidas on Sun Jul 20 03:10:35 2025
    On Thu, 17 Jul 2025 12:44:11 -0700, Kalkidas <eat@joes.pub> wrote in <105bjqb$1hhh0$1@dont-email.me>:

    On 7/17/2025 3:53 AM, Athel Cornish-Bowden wrote:
    On 2025-07-17 08:56:37 +0000, Kerr-Mudd, John said:

    On Thu, 17 Jul 2025 15:44:28 +1000 MarkE <me22over7@gmail.com> wrote:

    From this recent EN article:
    https://evolutionnews.org/2025/07/new-article-from-james-tour-
    undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide >>>> chain elongation under prebiotic conditions is very long. Yang et al.
    (2025) identify numerous barriers to sustained polypeptide growth,
    including the formation of non-peptide linkages and cyclic
    structures, stringent environmental requirements, and unfavorable
    thermodynamics. Their analysis establishes that the rate of growth
    must be far smaller than one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200
    amino acids would require over six months. However, the growing chain
    would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter
    half-life and encounters additional chemical and structural hurdles
    during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010

    No doubt this paper will be critiqued and disputed, but it is I think
    an example of the ongoing scrutiny and developing fundamental
    challenges to OoL. My prediction is these will continue to emerge,
    weakening materialistic abiogenesis and strengthening ID's core
    claim.



    ID has no science; it doesn't explain anything. It's classic God of
    the Gaps.  But you've been told before. PS get a better news source.

    And people interested in serious science don't look for it in Evolution
    News.


    The evolutionnews.org article merely summarizes a peer-reviewed
    scientific paper, for which the link is given.

    "sciendo.com" isn't what you think it is.

    Don't take my word for it -- go look for yourself.

    --
    -v

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From Kalkidas@21:1/5 to Martin Harran on Sun Jul 20 07:26:34 2025
    On 7/20/2025 6:15 AM, Martin Harran wrote:
    On Sat, 19 Jul 2025 11:38:07 -0700, Kalkidas <eat@joes.pub> wrote:

    On 7/17/2025 11:37 PM, Martin Harran wrote:
    On Thu, 17 Jul 2025 12:46:47 -0700, Kalkidas <eat@joes.pub> wrote:

    On 7/17/2025 11:23 AM, Martin Harran wrote:
    On Thu, 17 Jul 2025 15:44:28 +1000, MarkE <me22over7@gmail.com> wrote: >>>>>
    From this recent EN article:
    https://evolutionnews.org/2025/07/new-article-from-james-tour-undermines-a-pillar-of-origin-of-life-theories/

    'In comparison to a protein’s half-life, the rate of polypeptide chain >>>>>> elongation under prebiotic conditions is very long. Yang et al. (2025) >>>>>> identify numerous barriers to sustained polypeptide growth, including >>>>>> the formation of non-peptide linkages and cyclic structures, stringent >>>>>> environmental requirements, and unfavorable thermodynamics. Their
    analysis establishes that the rate of growth must be far smaller than >>>>>> one added amino acid per chain per day."

    "Even assuming one addition each day, synthesizing a protein of 200 >>>>>> amino acids would require over six months. However, the growing chain >>>>>> would almost certainly degrade in a much shorter time span. The
    challenge is even greater for RNA, which has a significantly shorter >>>>>> half-life and encounters additional chemical and structural hurdles >>>>>> during formation."

    Paper here: https://sciendo.com/article/10.2478/biocosmos-2025-0010 >>>>>>
    No doubt this paper will be critiqued and disputed, but it is I think an >>>>>> example of the ongoing scrutiny and developing fundamental challenges to >>>>>> OoL. My prediction is these will continue to emerge, weakening
    materialistic abiogenesis and strengthening ID's core claim.


    You have clearly still not grasped the principle that you cannot
    insist that *must have been* the butler who killed her ladyship simply >>>>> because you have shown it is very unlikely that his lordship did it. >>>>>

    Nature simultaneously destroys what it (allegedly) creates. And it
    destroys it faster than it (allegedly) creates it.

    If true then that means that the Intelligent Designer gets it wrong
    more often than he gets it right.


    What's "wrong" about it?

    Most of his designs didn't stand up to nature (according to you).

    Nature IS his design. So what could be "wrong" about it?


    Do you think this universe was created to be
    some kind of amusement park?

    No, why would you think that?

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)